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- W2030903558 abstract "The replication of measles virus was examined in cells treated with adenosine 3′,5′-monophosphate (cyclic AMP). Addition of 1 mM exogenous cyclic AMP to human amnion cell cultures (AV3) productively infected with the Edmonston strain of measles virus completely inhibited the formation of multinucleated giant cells and reduced the production of infectious virus particles by greater than 99%. While infected cyclic AMP-treated cells demonstrated measles virus antigens, discrete intracellular viral inclusion bodies were smaller and were observed much less frequently than in infected control cultures. Electron microscopy of the nucleotide-inhibited, infected cells showed that virus capsids of the “smooth” type were present in the cellular cytoplasm, but “granular” or “fuzzy” capsids were not. In addition, the association of virus nucleocapsids with the cell membrane and the budding of complete virion particles were not seen in the cyclic nucleotide-treated cultures. Analysis of infected cell immunoprecipitates by sodium dodecyl sulfate -polyacrylamide gel electrophoresis showed that the synthesis of the P and M polypeptides of the virus was significantly reduced in the nucleotide-treated infections. These data suggest that exogenous cyclic AMP inhibits the assembly of measles virions in infected AV3 cells by specifically blocking the synthesis of certain viral proteins." @default.
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- W2030903558 title "Inhibition of measles virus replication by cyclic AMP" @default.
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- W2030903558 doi "https://doi.org/10.1016/0042-6822(80)90255-x" @default.
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