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• W2030907498 abstract "Malignant hyperthermia (MH) is a potentially fatal pharmacogenetic syndrome caused by exposure to halogenated volatile anesthetics and/or depolarizing muscle relaxants. We have measured intracellular Ca 2+ concentration ([Ca 2+ ] i ) using double-barreled, Ca 2+ -selective microelectrodes in myoballs prepared from skeletal muscle of MH-susceptible (MHS) and MH-nonsusceptible (MHN) swine. Resting [Ca 2+ ] i was approximately twofold in MHS compared with MHN quiescent myoballs (232 ± 35 vs. 112 ± 11 nM). Treatment of myoballs with caffeine or 4-chloro- m-cresol (4-CmC) produced an elevation in [Ca 2+ ] i in both groups; however, the concentration required to cause a rise in [Ca 2+ ] i elevation was four times lower in MHS than in MHN skeletal muscle cells. Incubation of MHS cells with the fast-complexing Ca 2+ buffer BAPTA reduced [Ca 2+ ] i , raised the concentration of caffeine and 4-CmC required to cause an elevation of [Ca 2+ ] i , and reduced the amount of Ca 2+ release associated with exposure to any given concentration of caffeine or 4-CmC to MHN levels. These results suggest that the differences in the response of MHS skeletal myoballs to caffeine and 4-CmC may be mediated at least in part by the chronic high resting [Ca 2+ ] i levels in these cells." @default.
• W2030907498 created "2016-06-24" @default.
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• W2030907498 date "2005-03-01" @default.
• W2030907498 modified "2023-09-24" @default.
• W2030907498 title "Enhanced response to caffeine and 4-chloro-<i>m</i>-cresol in malignant hyperthermia-susceptible muscle is related in part to chronically elevated resting [Ca²⁺]_i" @default.
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• W2030907498 doi "https://doi.org/10.1152/ajpcell.00297.2004" @default.
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