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- W2030914984 abstract "Metabolic enzyme loci were some of the first genes accessible for molecular evolution and ecology research. New technologies now make the whole genome, transcriptome or proteome readily accessible, allowing unbiased scans for loci exhibiting significant differences in allele frequency or expression level and associated with phenotypes and/or responses to natural selection. With surprising frequency and in many cases in proportions greater than chance relative to other genes, glycolysis and TCA cycle enzyme loci appear among the genes with significant associations in these studies. Hence, there is an ongoing need to understand the basis for fitness effects of metabolic enzyme polymorphisms. Allele-specific effects on the binding affinity and catalytic rate of individual enzymes are well known, but often of uncertain significance because metabolic control theory and in vivo studies indicate that many individual metabolic enzymes do not affect pathway flux rate. I review research, so far little used in evolutionary biology, showing that metabolic enzyme substrates affect signalling pathways that regulate cell and organismal biology, and that these enzymes have moonlighting functions. To date there is little knowledge of how alleles in natural populations affect these phenotypes. I discuss an example in which alleles of a TCA enzyme locus associate with differences in a signalling pathway and development, organismal performance, and ecological dynamics. Ultimately, understanding how metabolic enzyme polymorphisms map to phenotypes and fitness remains a compelling and ongoing need for gaining robust knowledge of ecological and evolutionary processes." @default.
- W2030914984 created "2016-06-24" @default.
- W2030914984 creator A5057537074 @default.
- W2030914984 date "2013-10-23" @default.
- W2030914984 modified "2023-09-24" @default.
- W2030914984 title "Nature's inordinate fondness for metabolic enzymes: why metabolic enzyme loci are so frequently targets of selection" @default.
- W2030914984 cites W1502598760 @default.
- W2030914984 cites W1514689437 @default.
- W2030914984 cites W1521469208 @default.
- W2030914984 cites W1529622358 @default.
- W2030914984 cites W1559442263 @default.
- W2030914984 cites W1564767856 @default.
- W2030914984 cites W1606270396 @default.
- W2030914984 cites W1616394907 @default.
- W2030914984 cites W1642162696 @default.
- W2030914984 cites W1773163371 @default.
- W2030914984 cites W1846626178 @default.
- W2030914984 cites W1864895841 @default.
- W2030914984 cites W1902690430 @default.
- W2030914984 cites W1915195716 @default.
- W2030914984 cites W1963894699 @default.
- W2030914984 cites W1964150693 @default.
- W2030914984 cites W1964855107 @default.
- W2030914984 cites W1965047102 @default.
- W2030914984 cites W1969585647 @default.
- W2030914984 cites W1969653931 @default.
- W2030914984 cites W1970252458 @default.
- W2030914984 cites W1970263229 @default.
- W2030914984 cites W1975918337 @default.
- W2030914984 cites W1977091551 @default.
- W2030914984 cites W1978083828 @default.
- W2030914984 cites W1979247094 @default.
- W2030914984 cites W1981244256 @default.
- W2030914984 cites W1982317185 @default.
- W2030914984 cites W1984560843 @default.
- W2030914984 cites W1990593807 @default.
- W2030914984 cites W1990785115 @default.
- W2030914984 cites W1993608360 @default.
- W2030914984 cites W1996504670 @default.
- W2030914984 cites W1997510569 @default.
- W2030914984 cites W1998615031 @default.
- W2030914984 cites W2000212544 @default.
- W2030914984 cites W2000295349 @default.
- W2030914984 cites W2001686534 @default.
- W2030914984 cites W2001793263 @default.
- W2030914984 cites W2004183689 @default.
- W2030914984 cites W2006874319 @default.
- W2030914984 cites W2008438855 @default.
- W2030914984 cites W2009149980 @default.
- W2030914984 cites W2009577529 @default.
- W2030914984 cites W2009714443 @default.
- W2030914984 cites W2016962395 @default.
- W2030914984 cites W2017115075 @default.
- W2030914984 cites W2019968569 @default.
- W2030914984 cites W2021773250 @default.
- W2030914984 cites W2024857001 @default.
- W2030914984 cites W2030634993 @default.
- W2030914984 cites W2032993759 @default.
- W2030914984 cites W2035469748 @default.
- W2030914984 cites W2036289648 @default.
- W2030914984 cites W2038634422 @default.
- W2030914984 cites W2043660795 @default.
- W2030914984 cites W2044662583 @default.
- W2030914984 cites W2047862598 @default.
- W2030914984 cites W2047867594 @default.
- W2030914984 cites W2050964782 @default.
- W2030914984 cites W2052641583 @default.
- W2030914984 cites W2053359084 @default.
- W2030914984 cites W2054233487 @default.
- W2030914984 cites W2054618128 @default.
- W2030914984 cites W2054958213 @default.
- W2030914984 cites W2055063491 @default.
- W2030914984 cites W2055486023 @default.
- W2030914984 cites W2057199368 @default.
- W2030914984 cites W2057300033 @default.
- W2030914984 cites W2058713700 @default.
- W2030914984 cites W2059643938 @default.
- W2030914984 cites W2063041018 @default.
- W2030914984 cites W2063311318 @default.
- W2030914984 cites W2063889859 @default.
- W2030914984 cites W2065498842 @default.
- W2030914984 cites W2065997193 @default.
- W2030914984 cites W2067553186 @default.
- W2030914984 cites W2067968682 @default.
- W2030914984 cites W2069694136 @default.
- W2030914984 cites W2069835594 @default.
- W2030914984 cites W2069954850 @default.
- W2030914984 cites W2070063455 @default.
- W2030914984 cites W2071283216 @default.
- W2030914984 cites W2071941077 @default.
- W2030914984 cites W2076320034 @default.
- W2030914984 cites W2078937704 @default.
- W2030914984 cites W2080183225 @default.
- W2030914984 cites W2081990464 @default.
- W2030914984 cites W2082615795 @default.
- W2030914984 cites W2086764330 @default.
- W2030914984 cites W2088323801 @default.
- W2030914984 cites W2090094575 @default.