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• W2030925819 abstract "The first syntheses of bioactive cryptophycins functionalized at unit D were accomplished in a one-pot Staudinger reduction/cyclization step. An azido precursor for the lower part of the backbone was introduced to minimize protective group chemistry and enable a very convenient synthesis of cryptophycin-52 and unit D cryptophycin analogues containing an ester or a free carboxylic acid for bioconjugations. Both new cryptophycin derivatives show high biological activity in cytotoxicity assays." @default.
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• W2030925819 date "2010-09-21" @default.
• W2030925819 modified "2023-10-10" @default.
• W2030925819 title "Approaches for the Synthesis of Functionalized Cryptophycins" @default.
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• W2030925819 doi "https://doi.org/10.1021/jo101563s" @default.
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