FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030926565> ?p ?o ?g. }

• W2030926565 endingPage "11398" @default.
• W2030926565 startingPage "11393" @default.
• W2030926565 abstract "Cannabinoids can evoke antihyperalgesia and antinociception at a peripheral site of action. However, the signaling pathways mediating these effects are not clearly understood. We tested the hypothesis that certain cannabinoids directly inhibit peripheral capsaicin-sensitive nociceptive neurons by dephosphorylating and desensitizing transient receptor potential vanilloid 1 (TRPV1) via a calcium calcineurin-dependent mechanism. Application of the cannabinoid WIN 55,212-2 (WIN) to cultured trigeminal (TG) neurons or isolated skin biopsies rapidly and significantly inhibited capsaicin-activated inward currents and neuropeptide exocytosis by a mechanism requiring the presence of extracellular calcium. The inhibitory effect did not involve activation of G protein-coupled cannabinoid receptors, because neither pertussis toxin nor GDPβS treatments altered the WIN effect. However, application of WIN-activated calcineurin, as measured by nuclear translocation of the nuclear factor of activated T cells (NFAT)c4 transcription factor, dephosphorylated TRPV1. The WIN-induced desensitization of TRPV1 was mediated by calcineurin, because the application of structurally distinct calcineurin antagonists (calcineurin autoinhibitory peptide and cyclosporine/cyclophilin complex) abolished WIN-induced inhibition of capsaicin-evoked inward currents and neuropeptide exocytosis. This mechanism also contributed to peripheral antinociceptive/antihyperalgesic effects of WIN because pretreatment with the calcineurin antagonist calcineurin autoinhibitory peptide (CAIP) significantly reduced peripherally mediated WIN effects in two behavioral models. Collectively, these data demonstrate that cannabinoids such as WIN directly inhibit TRPV1 functional activities via a calcineurin pathway that represents a mechanism of cannabinoid actions at peripheral sites." @default.
• W2030926565 created "2016-06-24" @default.
• W2030926565 creator A5014441807 @default.
• W2030926565 creator A5033043600 @default.
• W2030926565 creator A5040294572 @default.
• W2030926565 creator A5042090795 @default.
• W2030926565 creator A5054295319 @default.
• W2030926565 creator A5090742260 @default.
• W2030926565 date "2006-07-25" @default.
• W2030926565 modified "2023-10-18" @default.
• W2030926565 title "The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin" @default.
• W2030926565 cites W1488329806 @default.
• W2030926565 cites W1492591187 @default.
• W2030926565 cites W1527988408 @default.
• W2030926565 cites W1564453175 @default.
• W2030926565 cites W1907919347 @default.
• W2030926565 cites W1917715377 @default.
• W2030926565 cites W1919664406 @default.
• W2030926565 cites W1952328179 @default.
• W2030926565 cites W1966150192 @default.
• W2030926565 cites W1971566600 @default.
• W2030926565 cites W1978828934 @default.
• W2030926565 cites W1984033377 @default.
• W2030926565 cites W1984780148 @default.
• W2030926565 cites W1984928802 @default.
• W2030926565 cites W1988115596 @default.
• W2030926565 cites W1992601827 @default.
• W2030926565 cites W1999939316 @default.
• W2030926565 cites W2004728887 @default.
• W2030926565 cites W2011889630 @default.
• W2030926565 cites W2014007136 @default.
• W2030926565 cites W2034433367 @default.
• W2030926565 cites W2035257142 @default.
• W2030926565 cites W2038288674 @default.
• W2030926565 cites W2039106853 @default.
• W2030926565 cites W2039257552 @default.
• W2030926565 cites W2039522435 @default.
• W2030926565 cites W2046403343 @default.
• W2030926565 cites W2050781058 @default.
• W2030926565 cites W2056188558 @default.
• W2030926565 cites W2062606765 @default.
• W2030926565 cites W2066559312 @default.
• W2030926565 cites W2070535004 @default.
• W2030926565 cites W2071170359 @default.
• W2030926565 cites W2075894678 @default.
• W2030926565 cites W2082252301 @default.
• W2030926565 cites W2086674879 @default.
• W2030926565 cites W2089478925 @default.
• W2030926565 cites W2091491637 @default.
• W2030926565 cites W2095821587 @default.
• W2030926565 cites W2098443650 @default.
• W2030926565 cites W2111910977 @default.
• W2030926565 cites W2112111910 @default.
• W2030926565 cites W2119832782 @default.
• W2030926565 cites W2132119503 @default.
• W2030926565 cites W2134742719 @default.
• W2030926565 cites W2134824442 @default.
• W2030926565 cites W2135475275 @default.
• W2030926565 cites W2150033209 @default.
• W2030926565 cites W2150682757 @default.
• W2030926565 cites W2169980429 @default.
• W2030926565 cites W2171584675 @default.
• W2030926565 cites W2172242651 @default.
• W2030926565 cites W95140143 @default.
• W2030926565 doi "https://doi.org/10.1073/pnas.0603861103" @default.
• W2030926565 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1544096" @default.
• W2030926565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16849427" @default.
• W2030926565 hasPublicationYear "2006" @default.
• W2030926565 type Work @default.
• W2030926565 sameAs 2030926565 @default.
• W2030926565 citedByCount "148" @default.
• W2030926565 countsByYear W20309265652012 @default.
• W2030926565 countsByYear W20309265652013 @default.
• W2030926565 countsByYear W20309265652014 @default.
• W2030926565 countsByYear W20309265652015 @default.
• W2030926565 countsByYear W20309265652016 @default.
• W2030926565 countsByYear W20309265652017 @default.
• W2030926565 countsByYear W20309265652018 @default.
• W2030926565 countsByYear W20309265652019 @default.
• W2030926565 countsByYear W20309265652020 @default.
• W2030926565 countsByYear W20309265652021 @default.
• W2030926565 countsByYear W20309265652022 @default.
• W2030926565 crossrefType "journal-article" @default.
• W2030926565 hasAuthorship W2030926565A5014441807 @default.
• W2030926565 hasAuthorship W2030926565A5033043600 @default.
• W2030926565 hasAuthorship W2030926565A5040294572 @default.
• W2030926565 hasAuthorship W2030926565A5042090795 @default.
• W2030926565 hasAuthorship W2030926565A5054295319 @default.
• W2030926565 hasAuthorship W2030926565A5090742260 @default.
• W2030926565 hasBestOaLocation W20309265651 @default.
• W2030926565 hasConcept C126322002 @default.
• W2030926565 hasConcept C128057223 @default.
• W2030926565 hasConcept C148001335 @default.
• W2030926565 hasConcept C155164980 @default.
• W2030926565 hasConcept C160145004 @default.
• W2030926565 hasConcept C170493617 @default.
• W2030926565 hasConcept C185592680 @default.
• W2030926565 hasConcept C2776885963 @default.

• next