Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030927199> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2030927199 endingPage "85" @default.
- W2030927199 startingPage "82" @default.
- W2030927199 abstract "Abstract Mas-related gene G protein-coupled (Mrg) receptors have been identified to be uniquely distributed in subpopulations of small-diameter neurons in dorsal root and trigeminal ganglia in rodents and humans. It has been demonstrated that the activation of MrgC receptors in rodents inhibits pathological pain but does not alter pain sensitivity under normal conditions. In vitro studies have suggested that the activation of MrgX1 or MrgD receptors is associated with dual G proteins. The current study was designed to determine whether rat MrgC receptors are coupled to Gi/o and Gq proteins and what pain behavior response activation of these proteins could mediate. Intrathecal (i.t.) administration of bovine adrenal medulla 8-22 (BAM8-22), a specific MrgC receptor agonist, dose-dependently decreased tail flick latency (TFL) in rats pretreated with pertussis toxin, but not with saline. On the other hand, i.t. injected BAM8-22 increased TFL in the presence of U73122 but produced no changes in TFL following pretreatment with saline. The results in the present study provide in vivo evidence that both Gi/o and Gq proteins are involved in MrgC receptor signaling." @default.
- W2030927199 created "2016-06-24" @default.
- W2030927199 creator A5013123610 @default.
- W2030927199 creator A5034818470 @default.
- W2030927199 creator A5056246750 @default.
- W2030927199 date "2012-04-01" @default.
- W2030927199 modified "2023-09-25" @default.
- W2030927199 title "Dual modulation effects of Mas-related gene (Mrg) receptors on pain sensitivity in rats" @default.
- W2030927199 cites W1493514243 @default.
- W2030927199 cites W1653242653 @default.
- W2030927199 cites W1655590724 @default.
- W2030927199 cites W1925074995 @default.
- W2030927199 cites W1978542151 @default.
- W2030927199 cites W1982643415 @default.
- W2030927199 cites W1995705528 @default.
- W2030927199 cites W1997068355 @default.
- W2030927199 cites W2009952807 @default.
- W2030927199 cites W2033124711 @default.
- W2030927199 cites W2047645403 @default.
- W2030927199 cites W2061051002 @default.
- W2030927199 cites W2068185359 @default.
- W2030927199 cites W2079212189 @default.
- W2030927199 cites W2080875376 @default.
- W2030927199 cites W2083566192 @default.
- W2030927199 cites W2087004322 @default.
- W2030927199 cites W2090905251 @default.
- W2030927199 cites W2107270966 @default.
- W2030927199 cites W2111439245 @default.
- W2030927199 cites W2118866905 @default.
- W2030927199 cites W2121367388 @default.
- W2030927199 cites W2123046464 @default.
- W2030927199 cites W2124673849 @default.
- W2030927199 cites W2127234770 @default.
- W2030927199 cites W2157856809 @default.
- W2030927199 doi "https://doi.org/10.1016/j.neulet.2012.02.062" @default.
- W2030927199 hasPublicationYear "2012" @default.
- W2030927199 type Work @default.
- W2030927199 sameAs 2030927199 @default.
- W2030927199 citedByCount "3" @default.
- W2030927199 countsByYear W20309271992017 @default.
- W2030927199 countsByYear W20309271992022 @default.
- W2030927199 crossrefType "journal-article" @default.
- W2030927199 hasAuthorship W2030927199A5013123610 @default.
- W2030927199 hasAuthorship W2030927199A5034818470 @default.
- W2030927199 hasAuthorship W2030927199A5056246750 @default.
- W2030927199 hasConcept C121332964 @default.
- W2030927199 hasConcept C123079801 @default.
- W2030927199 hasConcept C124952713 @default.
- W2030927199 hasConcept C126322002 @default.
- W2030927199 hasConcept C127413603 @default.
- W2030927199 hasConcept C142362112 @default.
- W2030927199 hasConcept C15744967 @default.
- W2030927199 hasConcept C169760540 @default.
- W2030927199 hasConcept C170493617 @default.
- W2030927199 hasConcept C21200559 @default.
- W2030927199 hasConcept C24326235 @default.
- W2030927199 hasConcept C24890656 @default.
- W2030927199 hasConcept C2780980858 @default.
- W2030927199 hasConcept C71924100 @default.
- W2030927199 hasConceptScore W2030927199C121332964 @default.
- W2030927199 hasConceptScore W2030927199C123079801 @default.
- W2030927199 hasConceptScore W2030927199C124952713 @default.
- W2030927199 hasConceptScore W2030927199C126322002 @default.
- W2030927199 hasConceptScore W2030927199C127413603 @default.
- W2030927199 hasConceptScore W2030927199C142362112 @default.
- W2030927199 hasConceptScore W2030927199C15744967 @default.
- W2030927199 hasConceptScore W2030927199C169760540 @default.
- W2030927199 hasConceptScore W2030927199C170493617 @default.
- W2030927199 hasConceptScore W2030927199C21200559 @default.
- W2030927199 hasConceptScore W2030927199C24326235 @default.
- W2030927199 hasConceptScore W2030927199C24890656 @default.
- W2030927199 hasConceptScore W2030927199C2780980858 @default.
- W2030927199 hasConceptScore W2030927199C71924100 @default.
- W2030927199 hasFunder F4320321001 @default.
- W2030927199 hasIssue "1" @default.
- W2030927199 hasLocation W20309271991 @default.
- W2030927199 hasOpenAccess W2030927199 @default.
- W2030927199 hasPrimaryLocation W20309271991 @default.
- W2030927199 hasRelatedWork W2018231959 @default.
- W2030927199 hasRelatedWork W2092475415 @default.
- W2030927199 hasRelatedWork W2149828036 @default.
- W2030927199 hasRelatedWork W2184913025 @default.
- W2030927199 hasRelatedWork W2235225463 @default.
- W2030927199 hasRelatedWork W2410818849 @default.
- W2030927199 hasRelatedWork W2528112452 @default.
- W2030927199 hasRelatedWork W3006913060 @default.
- W2030927199 hasRelatedWork W3100570026 @default.
- W2030927199 hasRelatedWork W4233655917 @default.
- W2030927199 hasVolume "514" @default.
- W2030927199 isParatext "false" @default.
- W2030927199 isRetracted "false" @default.
- W2030927199 magId "2030927199" @default.
- W2030927199 workType "article" @default.