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- W2030938503 abstract "Background: Pro‐inflammatory cytokines are actively involved in graft‐versus host‐disease (GvHD) aetiology. Treatment of GvHD, using extracorporeal photopheresis (ECP), has demonstrated clinical efficacy. ECP rapidly reduces the number of T cells that produce tumour necrosis factor α (TNFα), interferon γ (IFNγ) and interleukin (IL)2. ECP‐treated cells are re‐infused immediately after completion of treatment. This study attempted to determine the influence that ECP‐treated cells would have on untreated cells following re‐infusion. Methods: Heparinized samples were taken from 10 chronic GvHD patients, pre‐ECP and immediately prior to re‐infusion (post‐ECP). Lymphocytes and monocytes were isolated using magnetic separation. The post‐ECP lymphocytes were mixed with pre‐ECP monocytes, while the post‐ECP monocytes and pre‐ECP lymphocytes were combined. After suitable stimulation, the T cells were tested for intracellular TNFα, IFNγ and IL2, while the monocytes were evaluated for TNFα, IL1α, IL1β, IL6 and IL8. Results: Although cytokine secretion is decreased in T cells exposed to ECP, pre‐ECP T cells were unaffected by post‐ECP monocytes. Post‐ECP monocytes demonstrated a reduction in cytokine secretion. Furthermore, untreated monocytes down‐regulated cytokine production following exposure to ECP‐treated lymphocytes. Conclusion: ECP has both a direct and indirect immunosuppressive action, both of which may be beneficial in the treatment of GvHD." @default.
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- W2030938503 date "2005-11-24" @default.
- W2030938503 modified "2023-10-15" @default.
- W2030938503 title "Lymphocytes treated by extracorporeal photopheresis can down-regulate cytokine production in untreated monocytes" @default.
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- W2030938503 doi "https://doi.org/10.1111/j.1600-0781.2005.00192.x" @default.
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