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• W2030943679 abstract "Repeated transient increases in intracellular free calcium levels ([Ca2+]i) are required for polymorphonuclear neutrophil migration on two-dimensional surfaces coated with fibronectin or vitronectin. Cells in which [Ca2+]iis buffered with quin2 become stuck on these substrates. Neutrophils migrating through the extracellular matrix in vivo encounter these and other substrates in a three-dimensional architecture that may alter the spatial distribution of adhesion receptors in contact with the matrix. In this study, we used fluorescence confocal microscopy to obtain moving three-dimensional images of neutrophils migrating through a biological tissue (human amnion) in the presence and absence of [Ca2+]i-buffering with quin2. In the absence of buffering, [Ca2+]itransients similar to those seen in cells migrating in two-dimensions were observed. [Ca2+]i-buffered neutrophils were able to migrate into the matrix, but they became attached firmly to the substrate at the rear of the cell, resulting in a drastically elongated morphology. Immunofluorescence revealed that neutrophils adhered to regions of the matrix that contained fibronectin. RGD-containing peptides and antibodies that block integrin adhesion receptors for fibronectin and vitronectin were able to rescue the migration of quin2-treated cells through three-dimensional gels containing fibronectin and vitronectin. These data show that neutrophils migrating throughphysiologically relevant, three-dimensional matrices undergo repetitive increases in [Ca2+]ithat are required for integrin-mediated detachment from the matrix. J. Cell. Physiol. 171:168–178, 1997. © 1997 Wiley-Liss, Inc." @default.
• W2030943679 created "2016-06-24" @default.
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• W2030943679 date "1997-05-01" @default.
• W2030943679 modified "2023-10-15" @default.
• W2030943679 title "Effects of buffering intracellular free calcium on neutrophil migration through three-dimensional matrices" @default.
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• W2030943679 doi "https://doi.org/10.1002/(sici)1097-4652(199705)171:2<168::aid-jcp7>3.0.co;2-m" @default.
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