FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030947105> ?p ?o ?g. }

• W2030947105 endingPage "179" @default.
• W2030947105 startingPage "172" @default.
• W2030947105 abstract "We previously identified a number of genes which were methylated significantly more frequently in the tumor compared to the non-cancerous lung tissues from non-small cell lung cancer (NSCLC) patients. Detection of methylation profiles of genes in NSCLC could provide insight into differential pathways to malignancy and lead to strategies for better treatment of individuals with NSCLC.We determined the DNA methylation status of 27 genes using quantitative MethyLight assays in lung tumor samples from 117 clinically well-characterized NSCLC patients.Hypermethylation was detected in one of more of the genes in 106 (91%) of 117 cases and was detected at high levels (percentage methylation reference (PMR)> or =4%) in 79% of NSCLC cases. Methylation of APC, CCND2, KCNH5 and, RUNX was significantly more frequent in adenocarcinomas compared to squamous cell carcinomas (SCC), while methylation of CDKN2A was more common in SCC. Hypermethylation of KCNH5, KCNH8, and RARB was more frequent in females compared to males. Hypermethylation of APC and CCND2 was inversely associated with proliferation score assessed by Ki-67 level.Our findings of differential gene hypermethylation frequencies in tumor tissues from patients with adenocarcinoma or squamous cell cancers and in females compared to males suggests that further investigation is warranted in order to more fully understand the potential disparate pathways and/or risk factors for NSCLC associated with histologic type and gender." @default.
• W2030947105 created "2016-06-24" @default.
• W2030947105 creator A5015414714 @default.
• W2030947105 creator A5031413544 @default.
• W2030947105 creator A5042427394 @default.
• W2030947105 creator A5050479239 @default.
• W2030947105 creator A5062575557 @default.
• W2030947105 creator A5084630436 @default.
• W2030947105 creator A5089628968 @default.
• W2030947105 creator A5090508593 @default.
• W2030947105 date "2010-08-01" @default.
• W2030947105 modified "2023-10-16" @default.
• W2030947105 title "DNA hypermethylation of tumors from non-small cell lung cancer (NSCLC) patients is associated with gender and histologic type" @default.
• W2030947105 cites W1503277017 @default.
• W2030947105 cites W1556996865 @default.
• W2030947105 cites W1965301144 @default.
• W2030947105 cites W1966663496 @default.
• W2030947105 cites W1969090518 @default.
• W2030947105 cites W1977457974 @default.
• W2030947105 cites W1979087114 @default.
• W2030947105 cites W1979362779 @default.
• W2030947105 cites W1983307705 @default.
• W2030947105 cites W1988624986 @default.
• W2030947105 cites W1988778997 @default.
• W2030947105 cites W1989585142 @default.
• W2030947105 cites W1989847639 @default.
• W2030947105 cites W1990393963 @default.
• W2030947105 cites W1993312546 @default.
• W2030947105 cites W1998516698 @default.
• W2030947105 cites W2005684058 @default.
• W2030947105 cites W2006305093 @default.
• W2030947105 cites W2010827483 @default.
• W2030947105 cites W2011676048 @default.
• W2030947105 cites W2011897191 @default.
• W2030947105 cites W2019985583 @default.
• W2030947105 cites W2020830322 @default.
• W2030947105 cites W2023505669 @default.
• W2030947105 cites W2026652423 @default.
• W2030947105 cites W2035916618 @default.
• W2030947105 cites W2045225294 @default.
• W2030947105 cites W2050619503 @default.
• W2030947105 cites W2052144177 @default.
• W2030947105 cites W2053493911 @default.
• W2030947105 cites W2083431979 @default.
• W2030947105 cites W2086811674 @default.
• W2030947105 cites W2091725797 @default.
• W2030947105 cites W2102232287 @default.
• W2030947105 cites W2105381419 @default.
• W2030947105 cites W2107357609 @default.
• W2030947105 cites W2126119763 @default.
• W2030947105 cites W2135114425 @default.
• W2030947105 cites W2138114387 @default.
• W2030947105 cites W2142862394 @default.
• W2030947105 cites W2148652009 @default.
• W2030947105 cites W2153219327 @default.
• W2030947105 cites W2155962678 @default.
• W2030947105 cites W2162970215 @default.
• W2030947105 cites W2164515515 @default.
• W2030947105 cites W2252688746 @default.
• W2030947105 cites W2333516377 @default.
• W2030947105 cites W4240859590 @default.
• W2030947105 doi "https://doi.org/10.1016/j.lungcan.2009.11.002" @default.
• W2030947105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2888601" @default.
• W2030947105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19945765" @default.
• W2030947105 hasPublicationYear "2010" @default.
• W2030947105 type Work @default.
• W2030947105 sameAs 2030947105 @default.
• W2030947105 citedByCount "59" @default.
• W2030947105 countsByYear W20309471052012 @default.
• W2030947105 countsByYear W20309471052013 @default.
• W2030947105 countsByYear W20309471052014 @default.
• W2030947105 countsByYear W20309471052015 @default.
• W2030947105 countsByYear W20309471052016 @default.
• W2030947105 countsByYear W20309471052017 @default.
• W2030947105 countsByYear W20309471052019 @default.
• W2030947105 countsByYear W20309471052020 @default.
• W2030947105 countsByYear W20309471052021 @default.
• W2030947105 countsByYear W20309471052022 @default.
• W2030947105 countsByYear W20309471052023 @default.
• W2030947105 crossrefType "journal-article" @default.
• W2030947105 hasAuthorship W2030947105A5015414714 @default.
• W2030947105 hasAuthorship W2030947105A5031413544 @default.
• W2030947105 hasAuthorship W2030947105A5042427394 @default.
• W2030947105 hasAuthorship W2030947105A5050479239 @default.
• W2030947105 hasAuthorship W2030947105A5062575557 @default.
• W2030947105 hasAuthorship W2030947105A5084630436 @default.
• W2030947105 hasAuthorship W2030947105A5089628968 @default.
• W2030947105 hasAuthorship W2030947105A5090508593 @default.
• W2030947105 hasBestOaLocation W20309471052 @default.
• W2030947105 hasConcept C104317684 @default.
• W2030947105 hasConcept C121608353 @default.
• W2030947105 hasConcept C126322002 @default.
• W2030947105 hasConcept C142724271 @default.
• W2030947105 hasConcept C143998085 @default.
• W2030947105 hasConcept C150194340 @default.
• W2030947105 hasConcept C190727270 @default.
• W2030947105 hasConcept C2776256026 @default.
• W2030947105 hasConcept C2778911148 @default.

• next