FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030951557> ?p ?o ?g. }

• W2030951557 endingPage "92" @default.
• W2030951557 startingPage "87" @default.
• W2030951557 abstract "1 Peritoneal mast cells from rat were co-incubated in vitro in a platelet aggregometer cuvette with washed rabbit platelets. In response to stimulation with calcium ionophore (A23187; 1–5 μm), the mast cells released a substance which stimulated the platelets to aggregate. These concentrations of ionophore did not stimulate platelet aggregation in the absence of mast cells, nor affect the responsiveness of the platelets to aggregation induced by thrombin or PAF. Release of a PAF-like substance was also observed in response to stimulation of the mast cells with antigen. 2 This pro-aggregatory activity is attributable to the release of PAF by the mast cells, since the activity could be abolished by preincubating the platelets with a specific PAF receptor antagonist (WEB 2086; 10 μm). Furthermore, the platelet-aggregating factor co-migrated with PAF on thin-layer chromatographs and could be abolished by incubation with phospholipase A2 (20 μg ml−1) or a specific antibody directed against PAF. 3 The release of PAF by peritoneal mast cells could be inhibited, in a concentration-dependent manner, by PF-5901 (IC50 of 3.9μm) or Wy-50,295 (IC50 of 1.2μm), two structurally similar compounds with inhibitory effects on leukotriene synthesis, as well as leukotriene D4 (LTD4) receptor antagonist properties. 4 Inhibition of PAF synthesis was not observed when the mast cells were incubated with a structurally unrelated 5-lipoxygenase inhibitor (A-64077), a structurally dissimilar inhibitor of 5-lipoxygenase activating protein (MK-886) or with a structurally related LTD4 receptor antagonist (MK-571) which lacks inhibitory effects on leukotriene synthesis, each at concentrations of up to 100 μm. 5 Neither PF-5901 nor Wy-50,295 (1 or 10 μm) significantly affected histamine release or prostaglandin D2 synthesis by peritoneal mast cells in response to calcium ionophore stimulation. 6 These results demonstrate the ability of a class of quinoline-based compounds to inhibit PAF synthesis by peritoneal mast cells. This activity does not appear to be related to effects of these compounds on leukotriene synthesis or LTD4 receptors. The ability of these compounds to inhibit PAF synthesis may contribute to their anti-inflammatory properties." @default.
• W2030951557 created "2016-06-24" @default.
• W2030951557 creator A5006782649 @default.
• W2030951557 creator A5025370923 @default.
• W2030951557 creator A5027937626 @default.
• W2030951557 creator A5065588213 @default.
• W2030951557 creator A5067135750 @default.
• W2030951557 creator A5081156917 @default.
• W2030951557 date "1992-01-01" @default.
• W2030951557 modified "2023-09-27" @default.
• W2030951557 title "Platelet-activating factor synthesis by peritoneal mast cells and its inhibition by two quinoline-based compounds" @default.
• W2030951557 cites W119903568 @default.
• W2030951557 cites W1520264805 @default.
• W2030951557 cites W1614197059 @default.
• W2030951557 cites W1642315092 @default.
• W2030951557 cites W1748740421 @default.
• W2030951557 cites W1858845313 @default.
• W2030951557 cites W1891076224 @default.
• W2030951557 cites W1931867546 @default.
• W2030951557 cites W1943563530 @default.
• W2030951557 cites W1975643047 @default.
• W2030951557 cites W1982674409 @default.
• W2030951557 cites W1987672928 @default.
• W2030951557 cites W1989802429 @default.
• W2030951557 cites W2009944327 @default.
• W2030951557 cites W2046262741 @default.
• W2030951557 cites W2061092989 @default.
• W2030951557 cites W2078262087 @default.
• W2030951557 cites W2090431966 @default.
• W2030951557 cites W2097871689 @default.
• W2030951557 cites W2101615486 @default.
• W2030951557 cites W2148988468 @default.
• W2030951557 cites W2261984195 @default.
• W2030951557 cites W2262822221 @default.
• W2030951557 cites W2314578266 @default.
• W2030951557 cites W2401742915 @default.
• W2030951557 cites W2414834571 @default.
• W2030951557 cites W99354255 @default.
• W2030951557 doi "https://doi.org/10.1111/j.1476-5381.1992.tb14215.x" @default.
• W2030951557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1908618" @default.
• W2030951557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1596692" @default.
• W2030951557 hasPublicationYear "1992" @default.
• W2030951557 type Work @default.
• W2030951557 sameAs 2030951557 @default.
• W2030951557 citedByCount "29" @default.
• W2030951557 countsByYear W20309515572012 @default.
• W2030951557 countsByYear W20309515572013 @default.
• W2030951557 countsByYear W20309515572014 @default.
• W2030951557 crossrefType "journal-article" @default.
• W2030951557 hasAuthorship W2030951557A5006782649 @default.
• W2030951557 hasAuthorship W2030951557A5025370923 @default.
• W2030951557 hasAuthorship W2030951557A5027937626 @default.
• W2030951557 hasAuthorship W2030951557A5065588213 @default.
• W2030951557 hasAuthorship W2030951557A5067135750 @default.
• W2030951557 hasAuthorship W2030951557A5081156917 @default.
• W2030951557 hasBestOaLocation W20309515571 @default.
• W2030951557 hasConcept C126322002 @default.
• W2030951557 hasConcept C134018914 @default.
• W2030951557 hasConcept C170493617 @default.
• W2030951557 hasConcept C181199279 @default.
• W2030951557 hasConcept C185592680 @default.
• W2030951557 hasConcept C203014093 @default.
• W2030951557 hasConcept C24998067 @default.
• W2030951557 hasConcept C2776042228 @default.
• W2030951557 hasConcept C2776452501 @default.
• W2030951557 hasConcept C2776885963 @default.
• W2030951557 hasConcept C2778078955 @default.
• W2030951557 hasConcept C2778122271 @default.
• W2030951557 hasConcept C2779014961 @default.
• W2030951557 hasConcept C2779020240 @default.
• W2030951557 hasConcept C2779543280 @default.
• W2030951557 hasConcept C2779726688 @default.
• W2030951557 hasConcept C41625074 @default.
• W2030951557 hasConcept C55493867 @default.
• W2030951557 hasConcept C71924100 @default.
• W2030951557 hasConcept C86803240 @default.
• W2030951557 hasConcept C89560881 @default.
• W2030951557 hasConcept C98274493 @default.
• W2030951557 hasConceptScore W2030951557C126322002 @default.
• W2030951557 hasConceptScore W2030951557C134018914 @default.
• W2030951557 hasConceptScore W2030951557C170493617 @default.
• W2030951557 hasConceptScore W2030951557C181199279 @default.
• W2030951557 hasConceptScore W2030951557C185592680 @default.
• W2030951557 hasConceptScore W2030951557C203014093 @default.
• W2030951557 hasConceptScore W2030951557C24998067 @default.
• W2030951557 hasConceptScore W2030951557C2776042228 @default.
• W2030951557 hasConceptScore W2030951557C2776452501 @default.
• W2030951557 hasConceptScore W2030951557C2776885963 @default.
• W2030951557 hasConceptScore W2030951557C2778078955 @default.
• W2030951557 hasConceptScore W2030951557C2778122271 @default.
• W2030951557 hasConceptScore W2030951557C2779014961 @default.
• W2030951557 hasConceptScore W2030951557C2779020240 @default.
• W2030951557 hasConceptScore W2030951557C2779543280 @default.
• W2030951557 hasConceptScore W2030951557C2779726688 @default.
• W2030951557 hasConceptScore W2030951557C41625074 @default.
• W2030951557 hasConceptScore W2030951557C55493867 @default.
• W2030951557 hasConceptScore W2030951557C71924100 @default.
• W2030951557 hasConceptScore W2030951557C86803240 @default.

• next