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- W2030955987 abstract "Inhibition of firing in the nigro-neostriatal dopamine system causes a rapid increase in the steady state levels of dopamine and an apparent activation in vivo of tyrosine hydroxylase. Although the apparent activity of tyrosine hydroxylase returns to normal after dopamine levels have been increased, the elevated dopamine levels do not appear to inhibit tyrosine hydroxylase below control levels. In contrast, when dopamine levels are increased by administration of a monoamine oxidase inhibitor, there is a significant reduction in striatal tyrosine hydroxylase activity as measured by the accumulation of dihydroxyphenylalanine (DOPA) after administration of a DOPA decarboxylase inhibitor. These results suggest that a blockade of impulse flow in the dopaminergic neurons causes a decrease in the sensitivity of striatal tyrosine hydroxylase to inhibition by elevated levels of dopamine. Administration of dopamine agonists reverses this effect and restores to normal the sensitivity of tyrosine hydroxylase to inhibition by endogenous dopamine. This effect of the dopamine agonists is prevented or reversed by administration of drugs which block dopamine receptors. Thus, the dopamine agonists appear to alter dopamine synthesis in the absence of impulse flow by interacting at a site, possibly on the presynaptic side of the dopamine terminal, which is similar to the post-synaptic dopa-minergic receptor and which appears capable of altering the sensitivity of tyrosine hydroxylase to inhibition by endogenous dopamine." @default.
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- W2030955987 title "Dopaminergic neurons—Alteration in the sensitivity of tyrosine hydroxylase to inhibition by endogenous dopamine after cessation of impulse flow" @default.
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- W2030955987 doi "https://doi.org/10.1016/0006-2952(76)90239-2" @default.
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