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• W2030967519 abstract "We studied the binding of [35S]t-butylbicyclophosphorothionate to the GABAA receptor-mediated chloride channel in the CA1 area and fascia dentata of control and Schaffer collateral kindled rats, by means of semi-quantitative autoradiography. The [35S]t-butylbicyclophosphorothionate binding was determined at three stages during kindling aquisition: (i) after six afterdischarges, (ii) after 14 afterdischarges and (iii) after the induction of fully kindled seizures. Furthermore, the binding was studied at the long-term stage, 28 days after the last generalized tonic-clonic seizure [Racine R. J. (1972) Electroenceph. clin. Neurophysiol.32, 281–294]. The binding was investigated at three [35S]t-butylbicyclophosphorothionate concentrations, 4, 47.5 ( KD value) and 180 nM ( Bmax value). A significant decrease in [35S]t-butylbicyclophosphorothionate binding in the CA1 area (−6 to −20%) and hilar formation (−17 to −37%), in one or more of the three [35S]t-butylbicyclophosphorothionate concentrations tested at the six and 14 afterdischarges and fully kindled stages was observed, but not significant changes at the long-term kindling stage were found. In contrast, the granular and molecular layers of the fascia dentata presented a significant increase in [35S]t-butylbicyclophosphorothionate binding (+15 to +38%) at the 14 afterdischarges, fully kindled and long-term kindled stages. These changes in [35S]t-butylbicyclophosphorothionate binding are in line with the previously observed changes in the [3H]muscimol [Titulaer M. N. G. et al. (1993) Neuroscience59, 817–826 and [3H]flunitrazepam [Titulaer M. N. G. et al. (submitted) binding, indicating that Schaffer collateral kindling stimulation is accompanied by changes of all three main GABAA receptor binding sites: (i) the “cage” convulsant site associated with the chloride channel, (ii) the GABAA agonist binding site and (iii) the benzodiazepine receptor agonist binding site. We hypothesize that this modification of GABAA/benzodiazepine receptor complex binding may underlie the changes in GABA-mediated inhibition in the receptor complex binding may underlie the changes in GABA-mediated inhibition in the kindled rat hippocampus, as previously indicated in electrophysiological studies, [Kamphuis W. et al. (1988) Brain Res.440, 205–215], consequently contributing to the establishment of a kindling stimulation induced epileptogenic focus." @default.
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• W2030967519 title "Autoradiographic analysis of [35S]t-butylbicyclophosphorothionate binding in kindled rat hippocampus shows different changes in CA1 area and fascia dentata" @default.
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• W2030967519 doi "https://doi.org/10.1016/0306-4522(94)00570-u" @default.
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