FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030972012> ?p ?o ?g. }

• W2030972012 endingPage "21" @default.
• W2030972012 startingPage "17" @default.
• W2030972012 abstract "Chronic inflammatory response in the brain is a characteristic etiopathology of various neurodegenerative diseases; consequently increasing the intrinsic anti-inflammatory potency could be an especially desirable strategy to prevent inflammation-related neuronal injuries. Transcription factor NF-E2-related factor-2 (Nrf2)-mediated control of redox homeostasis may participate in the modulation of microglial responses by regulating expression of important antioxidant and phase II detoxification genes. In our present work, we show that artesunate, a semi-synthetic derivative of anti-malarial agent artemisinin, attenuates LPS-induced inflammatory responses in microglial BV2 cells. Artesunate activates Nrf2-ARE system, and leads to an increase in the level of downstream heme oxygenase-1. Artesunate also activates PI3K/Akt, ERK, and JNK MAPKs signaling, but artesunate-induced activation of Nrf2 signaling and up-regulation of heme oxygenase-1 are ERK pathway-dependent. Collectively, this study demonstrates that artesunate is a potential activator of the Nrf2/ARE-dependent pathway and is therapeutically relevant to inflammatory responses of microglial cells." @default.
• W2030972012 created "2016-06-24" @default.
• W2030972012 creator A5042190712 @default.
• W2030972012 creator A5043053490 @default.
• W2030972012 creator A5050419054 @default.
• W2030972012 creator A5071864987 @default.
• W2030972012 creator A5083657626 @default.
• W2030972012 creator A5086770751 @default.
• W2030972012 date "2012-02-01" @default.
• W2030972012 modified "2023-10-18" @default.
• W2030972012 title "Artesunate activates Nrf2 pathway-driven anti-inflammatory potential through ERK signaling in microglial BV2 cells" @default.
• W2030972012 cites W1516709032 @default.
• W2030972012 cites W1570313205 @default.
• W2030972012 cites W1973050229 @default.
• W2030972012 cites W1976270928 @default.
• W2030972012 cites W1976436763 @default.
• W2030972012 cites W1990488806 @default.
• W2030972012 cites W1996886326 @default.
• W2030972012 cites W2001019228 @default.
• W2030972012 cites W2005904261 @default.
• W2030972012 cites W2013299486 @default.
• W2030972012 cites W2021650047 @default.
• W2030972012 cites W2024562851 @default.
• W2030972012 cites W2026950982 @default.
• W2030972012 cites W2033914311 @default.
• W2030972012 cites W2038324446 @default.
• W2030972012 cites W2039326711 @default.
• W2030972012 cites W2053063855 @default.
• W2030972012 cites W2053483879 @default.
• W2030972012 cites W2054618296 @default.
• W2030972012 cites W2057066264 @default.
• W2030972012 cites W2062432591 @default.
• W2030972012 cites W2074749191 @default.
• W2030972012 cites W2081797133 @default.
• W2030972012 cites W2084644507 @default.
• W2030972012 cites W2084780635 @default.
• W2030972012 cites W2120796946 @default.
• W2030972012 cites W2124568143 @default.
• W2030972012 cites W2126579954 @default.
• W2030972012 cites W2127975274 @default.
• W2030972012 cites W2128631317 @default.
• W2030972012 cites W2152785619 @default.
• W2030972012 doi "https://doi.org/10.1016/j.neulet.2011.12.034" @default.
• W2030972012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22227297" @default.
• W2030972012 hasPublicationYear "2012" @default.
• W2030972012 type Work @default.
• W2030972012 sameAs 2030972012 @default.
• W2030972012 citedByCount "52" @default.
• W2030972012 countsByYear W20309720122012 @default.
• W2030972012 countsByYear W20309720122013 @default.
• W2030972012 countsByYear W20309720122014 @default.
• W2030972012 countsByYear W20309720122015 @default.
• W2030972012 countsByYear W20309720122016 @default.
• W2030972012 countsByYear W20309720122017 @default.
• W2030972012 countsByYear W20309720122018 @default.
• W2030972012 countsByYear W20309720122020 @default.
• W2030972012 countsByYear W20309720122021 @default.
• W2030972012 countsByYear W20309720122022 @default.
• W2030972012 countsByYear W20309720122023 @default.
• W2030972012 crossrefType "journal-article" @default.
• W2030972012 hasAuthorship W2030972012A5042190712 @default.
• W2030972012 hasAuthorship W2030972012A5043053490 @default.
• W2030972012 hasAuthorship W2030972012A5050419054 @default.
• W2030972012 hasAuthorship W2030972012A5071864987 @default.
• W2030972012 hasAuthorship W2030972012A5083657626 @default.
• W2030972012 hasAuthorship W2030972012A5086770751 @default.
• W2030972012 hasConcept C170493617 @default.
• W2030972012 hasConcept C181199279 @default.
• W2030972012 hasConcept C185592680 @default.
• W2030972012 hasConcept C203014093 @default.
• W2030972012 hasConcept C25498285 @default.
• W2030972012 hasConcept C2776217839 @default.
• W2030972012 hasConcept C2776914184 @default.
• W2030972012 hasConcept C2778048844 @default.
• W2030972012 hasConcept C2778059366 @default.
• W2030972012 hasConcept C2778371730 @default.
• W2030972012 hasConcept C2779219270 @default.
• W2030972012 hasConcept C2779830541 @default.
• W2030972012 hasConcept C55493867 @default.
• W2030972012 hasConcept C57074206 @default.
• W2030972012 hasConcept C62478195 @default.
• W2030972012 hasConcept C75217442 @default.
• W2030972012 hasConcept C86554907 @default.
• W2030972012 hasConcept C86803240 @default.
• W2030972012 hasConcept C87753298 @default.
• W2030972012 hasConcept C88045685 @default.
• W2030972012 hasConcept C95444343 @default.
• W2030972012 hasConcept C98274493 @default.
• W2030972012 hasConceptScore W2030972012C170493617 @default.
• W2030972012 hasConceptScore W2030972012C181199279 @default.
• W2030972012 hasConceptScore W2030972012C185592680 @default.
• W2030972012 hasConceptScore W2030972012C203014093 @default.
• W2030972012 hasConceptScore W2030972012C25498285 @default.
• W2030972012 hasConceptScore W2030972012C2776217839 @default.
• W2030972012 hasConceptScore W2030972012C2776914184 @default.
• W2030972012 hasConceptScore W2030972012C2778048844 @default.
• W2030972012 hasConceptScore W2030972012C2778059366 @default.
• W2030972012 hasConceptScore W2030972012C2778371730 @default.

• next