FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030974764> ?p ?o ?g. }

• W2030974764 endingPage "656" @default.
• W2030974764 startingPage "652" @default.
• W2030974764 abstract "The requirements for lectin-induced interleukin 2 (IL2) production by human T cells have been investigated. With two different types of T cells, the Jurkat T cell lymphoma and highly purified HLA class II- peripheral T cells, the amount of IL2 produced was strongly dependent on the lectin concentration used. Addition of accessory cells caused a shift in the dose-response curve, resulting in strongly enhanced IL2 production at low concentrations. Thus, the (absolute) accessory cell dependency for T cells to produce IL2 is defined by experimental conditions. Only at lectin concentrations that were found to be optimal in the presence of accessory cells, removal of these cells abrogates IL2 production. Furthermore, after depletion of monocytes IL 2 production by peripheral T cells became almost completely dependent on the presence of thiols in the culture medium. In contrast, the IL2 production by the Jurkat line was not influenced by addition of thiols. The Jurkat model was used to study the nature of accessory cell because this cell line does not show any reactivity to allogeneic cells. Various myeloid and B lymphoid cell lines were tested as accessory cells. The capacity to function as accessory cell was not related to the monocytic origin of the cell. B cell lines were far more effective than monocytes, as two HLA class II- monocytic cell lines were not active. Even after HLA class II determinants were induced on these cells by incubation with an interferon-gamma-containing conditioned medium, they failed to act as as accessory cells. These experiments question the importance of HLA class II molecules and monokines, such as IL1, for lectin-induced IL2 production." @default.
• W2030974764 created "2016-06-24" @default.
• W2030974764 creator A5024514544 @default.
• W2030974764 creator A5058198903 @default.
• W2030974764 creator A5075154005 @default.
• W2030974764 date "1985-01-01" @default.
• W2030974764 modified "2023-09-25" @default.
• W2030974764 title "T cell triggering by lectins I. Requirements for interleukin 2 production;er lectin concentration determines the accessory cell dependency" @default.
• W2030974764 cites W1976028802 @default.
• W2030974764 cites W1980046186 @default.
• W2030974764 cites W1982578624 @default.
• W2030974764 cites W2000339480 @default.
• W2030974764 cites W2000692160 @default.
• W2030974764 cites W2002708404 @default.
• W2030974764 cites W2008057228 @default.
• W2030974764 cites W2009917344 @default.
• W2030974764 cites W2010105075 @default.
• W2030974764 cites W2014973235 @default.
• W2030974764 cites W2020128766 @default.
• W2030974764 cites W2027784386 @default.
• W2030974764 cites W2031391416 @default.
• W2030974764 cites W2035512145 @default.
• W2030974764 cites W2040749622 @default.
• W2030974764 cites W2049239446 @default.
• W2030974764 cites W2055275614 @default.
• W2030974764 cites W2056280250 @default.
• W2030974764 cites W2057696642 @default.
• W2030974764 cites W2066928489 @default.
• W2030974764 cites W2070170510 @default.
• W2030974764 cites W2071412606 @default.
• W2030974764 cites W2085146538 @default.
• W2030974764 cites W2087368335 @default.
• W2030974764 cites W2109594471 @default.
• W2030974764 cites W2112280951 @default.
• W2030974764 cites W2113300330 @default.
• W2030974764 cites W2113340999 @default.
• W2030974764 cites W2134913269 @default.
• W2030974764 cites W2137078804 @default.
• W2030974764 cites W2167857010 @default.
• W2030974764 cites W2168320467 @default.
• W2030974764 cites W2500716495 @default.
• W2030974764 cites W30763567 @default.
• W2030974764 doi "https://doi.org/10.1002/eji.1830150703" @default.
• W2030974764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3874077" @default.
• W2030974764 hasPublicationYear "1985" @default.
• W2030974764 type Work @default.
• W2030974764 sameAs 2030974764 @default.
• W2030974764 citedByCount "46" @default.
• W2030974764 countsByYear W20309747642013 @default.
• W2030974764 countsByYear W20309747642016 @default.
• W2030974764 countsByYear W20309747642021 @default.
• W2030974764 countsByYear W20309747642022 @default.
• W2030974764 crossrefType "journal-article" @default.
• W2030974764 hasAuthorship W2030974764A5024514544 @default.
• W2030974764 hasAuthorship W2030974764A5058198903 @default.
• W2030974764 hasAuthorship W2030974764A5075154005 @default.
• W2030974764 hasConcept C149532602 @default.
• W2030974764 hasConcept C153911025 @default.
• W2030974764 hasConcept C154317977 @default.
• W2030974764 hasConcept C179464577 @default.
• W2030974764 hasConcept C202751555 @default.
• W2030974764 hasConcept C203014093 @default.
• W2030974764 hasConcept C2776090121 @default.
• W2030974764 hasConcept C2777371288 @default.
• W2030974764 hasConcept C2778690821 @default.
• W2030974764 hasConcept C2780758401 @default.
• W2030974764 hasConcept C54355233 @default.
• W2030974764 hasConcept C55493867 @default.
• W2030974764 hasConcept C67662055 @default.
• W2030974764 hasConcept C81885089 @default.
• W2030974764 hasConcept C86803240 @default.
• W2030974764 hasConcept C8891405 @default.
• W2030974764 hasConcept C95444343 @default.
• W2030974764 hasConceptScore W2030974764C149532602 @default.
• W2030974764 hasConceptScore W2030974764C153911025 @default.
• W2030974764 hasConceptScore W2030974764C154317977 @default.
• W2030974764 hasConceptScore W2030974764C179464577 @default.
• W2030974764 hasConceptScore W2030974764C202751555 @default.
• W2030974764 hasConceptScore W2030974764C203014093 @default.
• W2030974764 hasConceptScore W2030974764C2776090121 @default.
• W2030974764 hasConceptScore W2030974764C2777371288 @default.
• W2030974764 hasConceptScore W2030974764C2778690821 @default.
• W2030974764 hasConceptScore W2030974764C2780758401 @default.
• W2030974764 hasConceptScore W2030974764C54355233 @default.
• W2030974764 hasConceptScore W2030974764C55493867 @default.
• W2030974764 hasConceptScore W2030974764C67662055 @default.
• W2030974764 hasConceptScore W2030974764C81885089 @default.
• W2030974764 hasConceptScore W2030974764C86803240 @default.
• W2030974764 hasConceptScore W2030974764C8891405 @default.
• W2030974764 hasConceptScore W2030974764C95444343 @default.
• W2030974764 hasIssue "7" @default.
• W2030974764 hasLocation W20309747641 @default.
• W2030974764 hasLocation W20309747642 @default.
• W2030974764 hasOpenAccess W2030974764 @default.
• W2030974764 hasPrimaryLocation W20309747641 @default.
• W2030974764 hasRelatedWork W1627093987 @default.
• W2030974764 hasRelatedWork W175859727 @default.
• W2030974764 hasRelatedWork W1951303258 @default.

• next