Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030979062> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2030979062 endingPage "149" @default.
- W2030979062 startingPage "145" @default.
- W2030979062 abstract "Nickel containing superoxide dismutase (NiSOD) is a metalloenzyme that catalyzes the disproportionation of O2−. In its reduced state, the Ni(II) ion is coordinated by two cis-cysteinates, an amine nitrogen and an amidate nitrogen atom. It thus bears a resemblance to the distal bis-cysteinate bis-amidate ligated nickel center of acetyl coenzyme A synthase. Using metallopeptide based NiSOD mimics derived from the first 12 residues of the NiSOD sequence we demonstrate that altering the primary coordination sphere from a bis-thiolate amine/amidate motif to a bis-thiolate bis-amidate motif changes the O2 and ROS stability of the metallopeptide. Using FT-IR, ESI-MS and S K-edge XAS we show that the bis-amidate bis-thiolate ligated metallopeptide {NiII(SODm1-Ac)} (SODm1-Ac = AcHN-HCDLPCGVYSPA-COOH) undergoes oxidation at one thiolate ligand in the presence of O2, converting it into a coordinated sulfinate. Upon exposure of {NiII(SODm1-Ac)} to O2− the metallopeptide undergoes extensive sulfur oxidation. This can be contrasted with the unacylated metallopeptide {NiII(SODm1)} which does not undergo sulfur based oxidation under these conditions. The biological implications of these findings are discussed." @default.
- W2030979062 created "2016-06-24" @default.
- W2030979062 creator A5052912332 @default.
- W2030979062 date "2013-12-01" @default.
- W2030979062 modified "2023-09-25" @default.
- W2030979062 title "Dioxygen and superoxide stability of metallopeptide based mimics of nickel containing superoxide dismutase: The influence of amine/amidate vs. bis-amidate ligation" @default.
- W2030979062 cites W1963626730 @default.
- W2030979062 cites W1964175983 @default.
- W2030979062 cites W1972089676 @default.
- W2030979062 cites W1993473196 @default.
- W2030979062 cites W2026373890 @default.
- W2030979062 cites W2033346584 @default.
- W2030979062 cites W2036815970 @default.
- W2030979062 cites W2038523016 @default.
- W2030979062 cites W2049774299 @default.
- W2030979062 cites W2065108088 @default.
- W2030979062 cites W2069140922 @default.
- W2030979062 cites W2081052344 @default.
- W2030979062 cites W2095323389 @default.
- W2030979062 cites W2105110220 @default.
- W2030979062 cites W2108479761 @default.
- W2030979062 cites W2149531858 @default.
- W2030979062 cites W2325256800 @default.
- W2030979062 cites W2949913820 @default.
- W2030979062 cites W4245383157 @default.
- W2030979062 cites W98700330 @default.
- W2030979062 doi "https://doi.org/10.1016/j.jinorgbio.2013.09.002" @default.
- W2030979062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24121677" @default.
- W2030979062 hasPublicationYear "2013" @default.
- W2030979062 type Work @default.
- W2030979062 sameAs 2030979062 @default.
- W2030979062 citedByCount "12" @default.
- W2030979062 countsByYear W20309790622014 @default.
- W2030979062 countsByYear W20309790622015 @default.
- W2030979062 countsByYear W20309790622016 @default.
- W2030979062 countsByYear W20309790622017 @default.
- W2030979062 countsByYear W20309790622021 @default.
- W2030979062 countsByYear W20309790622022 @default.
- W2030979062 crossrefType "journal-article" @default.
- W2030979062 hasAuthorship W2030979062A5052912332 @default.
- W2030979062 hasConcept C131779359 @default.
- W2030979062 hasConcept C155647269 @default.
- W2030979062 hasConcept C161790260 @default.
- W2030979062 hasConcept C17365422 @default.
- W2030979062 hasConcept C178790620 @default.
- W2030979062 hasConcept C181199279 @default.
- W2030979062 hasConcept C185592680 @default.
- W2030979062 hasConcept C2775838275 @default.
- W2030979062 hasConcept C2778591166 @default.
- W2030979062 hasConcept C2780795997 @default.
- W2030979062 hasConcept C504270822 @default.
- W2030979062 hasConcept C518881349 @default.
- W2030979062 hasConcept C544153396 @default.
- W2030979062 hasConcept C55493867 @default.
- W2030979062 hasConcept C71240020 @default.
- W2030979062 hasConcept C75473681 @default.
- W2030979062 hasConceptScore W2030979062C131779359 @default.
- W2030979062 hasConceptScore W2030979062C155647269 @default.
- W2030979062 hasConceptScore W2030979062C161790260 @default.
- W2030979062 hasConceptScore W2030979062C17365422 @default.
- W2030979062 hasConceptScore W2030979062C178790620 @default.
- W2030979062 hasConceptScore W2030979062C181199279 @default.
- W2030979062 hasConceptScore W2030979062C185592680 @default.
- W2030979062 hasConceptScore W2030979062C2775838275 @default.
- W2030979062 hasConceptScore W2030979062C2778591166 @default.
- W2030979062 hasConceptScore W2030979062C2780795997 @default.
- W2030979062 hasConceptScore W2030979062C504270822 @default.
- W2030979062 hasConceptScore W2030979062C518881349 @default.
- W2030979062 hasConceptScore W2030979062C544153396 @default.
- W2030979062 hasConceptScore W2030979062C55493867 @default.
- W2030979062 hasConceptScore W2030979062C71240020 @default.
- W2030979062 hasConceptScore W2030979062C75473681 @default.
- W2030979062 hasLocation W20309790621 @default.
- W2030979062 hasLocation W20309790622 @default.
- W2030979062 hasOpenAccess W2030979062 @default.
- W2030979062 hasPrimaryLocation W20309790621 @default.
- W2030979062 hasRelatedWork W1536516181 @default.
- W2030979062 hasRelatedWork W1998673029 @default.
- W2030979062 hasRelatedWork W2006841525 @default.
- W2030979062 hasRelatedWork W206771588 @default.
- W2030979062 hasRelatedWork W2125580632 @default.
- W2030979062 hasRelatedWork W2132423857 @default.
- W2030979062 hasRelatedWork W2361619310 @default.
- W2030979062 hasRelatedWork W2376326970 @default.
- W2030979062 hasRelatedWork W3106792141 @default.
- W2030979062 hasRelatedWork W3144122633 @default.
- W2030979062 hasVolume "129" @default.
- W2030979062 isParatext "false" @default.
- W2030979062 isRetracted "false" @default.
- W2030979062 magId "2030979062" @default.
- W2030979062 workType "article" @default.