FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030986059> ?p ?o ?g. }

• W2030986059 endingPage "413" @default.
• W2030986059 startingPage "413" @default.
• W2030986059 abstract "Sulfur mustard induces expression of metallothionein-1A in human airway epithelial cells Mohammad Reza Nourani1, Majid Ebrahimi1, Mehryar Habibi Roudkenar3, Ensieh Vahedi1, Mostafa Ghanei1, Abbas Ali Imani Fooladi21Chemical Injury Research Center; 2Microbial Product Research Center, Baqiyatallah University of Medical Sciences; 3Research Center, Iranian Blood Transfusion Organization, Tehran, IranBackground: Sulfur mustard can cause several long-term complications in the organs of individuals exposed to this toxic gas, and among these, pulmonary sequelae are the most important. More than 25 years after the Iran–Iraq war, thousands of Iranians are suffering from the chronic respiratory complications of sulfur mustard. Currently, based on several clinical findings, bronchiolitis obliterans is confirmed as the major diagnosis in these patients. Numerous studies have revealed that this disorder is strongly associated with oxidative stress due to excessive production of harmful reactive substances and decreased levels of endogenous antioxidants. Metallothioneins (MTs) are a group of low molecular weight sulfhydryl-rich intracellular proteins, and several isoforms have been identified in humans. MT-1A is an inducible and important MT isoform, which is transcriptionally activated by a variety of stress stimuli, such as free radicals.Methods: MT-1 mRNA expression and protein levels in endobronchial biopsy samples from 24 sulfur mustard-exposed patients and 15 unexposed control cases were evaluated by semiquantitative reverse transcriptase polymerase chain reaction, real-time reverse transcriptase polymerase chain reaction, and immunohistochemistry.Results: mRNA- MT-1A expression levels in sulfur mustard-exposed patients were upregulated compared with normal samples. Protein expression was also markedly higher in controls than in sulfur mustard-exposed patients.Conclusion: Upregulation of MT-1A mRNA in patients who have been exposed to sulfur mustard seems to be due to oxidative stress, which is induced in an attempt to ameliorate this harmful situation by reestablishment of homeostasis, but depletion of its protein might be due to secondary consequences of sulfur mustard toxicity, which are as yet not understood.Keywords: sulfur mustard, metallothionein-1A, airway, epithelial cells" @default.
• W2030986059 created "2016-06-24" @default.
• W2030986059 creator A5009851443 @default.
• W2030986059 creator A5013864393 @default.
• W2030986059 creator A5015033785 @default.
• W2030986059 creator A5018966563 @default.
• W2030986059 creator A5027428730 @default.
• W2030986059 creator A5050241462 @default.
• W2030986059 date "2011-05-01" @default.
• W2030986059 modified "2023-09-30" @default.
• W2030986059 title "Sulfur mustard induces expression of metallothionein-1A in human airway epithelial cells" @default.
• W2030986059 cites W1507877974 @default.
• W2030986059 cites W1538199768 @default.
• W2030986059 cites W164159169 @default.
• W2030986059 cites W1697885473 @default.
• W2030986059 cites W1972738314 @default.
• W2030986059 cites W1973352272 @default.
• W2030986059 cites W1973972704 @default.
• W2030986059 cites W1978569571 @default.
• W2030986059 cites W1989316780 @default.
• W2030986059 cites W1991479097 @default.
• W2030986059 cites W1993371622 @default.
• W2030986059 cites W1993934464 @default.
• W2030986059 cites W1994228441 @default.
• W2030986059 cites W1998398302 @default.
• W2030986059 cites W2007262700 @default.
• W2030986059 cites W2008521003 @default.
• W2030986059 cites W2010800806 @default.
• W2030986059 cites W2020550910 @default.
• W2030986059 cites W2022680393 @default.
• W2030986059 cites W2024365580 @default.
• W2030986059 cites W2041609597 @default.
• W2030986059 cites W2047497187 @default.
• W2030986059 cites W2055034179 @default.
• W2030986059 cites W2060435160 @default.
• W2030986059 cites W2072874968 @default.
• W2030986059 cites W2087317743 @default.
• W2030986059 cites W2096561225 @default.
• W2030986059 cites W2105205572 @default.
• W2030986059 cites W2106965417 @default.
• W2030986059 cites W2109762957 @default.
• W2030986059 cites W2112366228 @default.
• W2030986059 cites W2141109284 @default.
• W2030986059 cites W2144477621 @default.
• W2030986059 cites W2162674813 @default.
• W2030986059 cites W2169113398 @default.
• W2030986059 cites W2171105435 @default.
• W2030986059 cites W2256281019 @default.
• W2030986059 cites W2326126331 @default.
• W2030986059 cites W2421967891 @default.
• W2030986059 cites W3143980669 @default.
• W2030986059 doi "https://doi.org/10.2147/ijgm.s17916" @default.
• W2030986059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3119583" @default.
• W2030986059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21731892" @default.
• W2030986059 hasPublicationYear "2011" @default.
• W2030986059 type Work @default.
• W2030986059 sameAs 2030986059 @default.
• W2030986059 citedByCount "18" @default.
• W2030986059 countsByYear W20309860592012 @default.
• W2030986059 countsByYear W20309860592013 @default.
• W2030986059 countsByYear W20309860592014 @default.
• W2030986059 countsByYear W20309860592015 @default.
• W2030986059 countsByYear W20309860592016 @default.
• W2030986059 countsByYear W20309860592017 @default.
• W2030986059 countsByYear W20309860592018 @default.
• W2030986059 countsByYear W20309860592019 @default.
• W2030986059 countsByYear W20309860592020 @default.
• W2030986059 crossrefType "journal-article" @default.
• W2030986059 hasAuthorship W2030986059A5009851443 @default.
• W2030986059 hasAuthorship W2030986059A5013864393 @default.
• W2030986059 hasAuthorship W2030986059A5015033785 @default.
• W2030986059 hasAuthorship W2030986059A5018966563 @default.
• W2030986059 hasAuthorship W2030986059A5027428730 @default.
• W2030986059 hasAuthorship W2030986059A5050241462 @default.
• W2030986059 hasBestOaLocation W20309860591 @default.
• W2030986059 hasConcept C104317684 @default.
• W2030986059 hasConcept C105580179 @default.
• W2030986059 hasConcept C126322002 @default.
• W2030986059 hasConcept C142724271 @default.
• W2030986059 hasConcept C156719811 @default.
• W2030986059 hasConcept C203014093 @default.
• W2030986059 hasConcept C204232928 @default.
• W2030986059 hasConcept C20719415 @default.
• W2030986059 hasConcept C2776151105 @default.
• W2030986059 hasConcept C2780644109 @default.
• W2030986059 hasConcept C29730261 @default.
• W2030986059 hasConcept C4692481 @default.
• W2030986059 hasConcept C49105822 @default.
• W2030986059 hasConcept C55493867 @default.
• W2030986059 hasConcept C71924100 @default.
• W2030986059 hasConcept C86803240 @default.
• W2030986059 hasConceptScore W2030986059C104317684 @default.
• W2030986059 hasConceptScore W2030986059C105580179 @default.
• W2030986059 hasConceptScore W2030986059C126322002 @default.
• W2030986059 hasConceptScore W2030986059C142724271 @default.
• W2030986059 hasConceptScore W2030986059C156719811 @default.
• W2030986059 hasConceptScore W2030986059C203014093 @default.
• W2030986059 hasConceptScore W2030986059C204232928 @default.

• next