FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030989871> ?p ?o ?g. }

• W2030989871 endingPage "129" @default.
• W2030989871 startingPage "121" @default.
• W2030989871 abstract "The signal transduction mechanism of protein kinase FA/GSK-3α by tyrosine phosphorylation in A431 cells was investigated using calphostin C as an inhibitor for protein kinase C (PKC). Kinase Fa/GSK-3α could be tyrosine-dephosphorylated and inactivated to ∼ 10% of control in a concentration-dependent manner by 0.1–10 μM calphostin C (IC50, ∼ 1 μM), as demonstrated by immunoprecipitation of kinase Fa/GSK-3α from cell extracts, followed by phosphoamino acid analysis and by immunodetection in an antikinase Fa/GSK-3α immunoprecipitate kinase assay. In sharp contrast, down-regulation of PKC by 0.05 μM calphostin C (IC50, ∼ 0.05 μM for inhibiting PKC in cells) or by tumor promoter phorbol ester TPA was found to have stimulatory effect on the cellular activity of kinase Fa/GSK-3α, when processed under identical conditions. Furthermore, TPA-mediated down-regulation of PKC was found to have no effect on calphostin C-mediated tyrosine dephosphorylation/inactivation of kinase Fa/GSK-3α. Taken together, the results provide initial evidence that the PKC inhibitor calphostin C may induce tyrosine dephosphorylation/inactivation of kinase Fa/GSK-3α in a pathway independent of TPA-mediated down-regulation of PKC, representing a new mode of signal transduction for the regulation of this multisubstrate/multifunctional protein kinase by calphostin C in cells. Since kinase Fa/GSK-3α is a possible carcinoma dedifferentiation/progression-promoting factor, the results further suggest calphostin C as a potential anticancer drug involved in blocking carcinoma dedifferentiation/progression, possibly via inactivation of protein kinase FA/GSK-3α in tumor cells. © 1996 Wiley-Liss, Inc." @default.
• W2030989871 created "2016-06-24" @default.
• W2030989871 creator A5059926004 @default.
• W2030989871 creator A5070313655 @default.
• W2030989871 date "1996-01-01" @default.
• W2030989871 modified "2023-09-27" @default.
• W2030989871 title "Calphostin C induces tyrosine dephosphorylation/inactivation of protein kinase Fa/GSK-3α in a pathway independent of tumor promoter phorbol ester-mediated down-regulation of protein kinase C" @default.
• W2030989871 cites W1039919788 @default.
• W2030989871 cites W1488137693 @default.
• W2030989871 cites W1518972222 @default.
• W2030989871 cites W1519022452 @default.
• W2030989871 cites W1519683126 @default.
• W2030989871 cites W1534965462 @default.
• W2030989871 cites W1578370366 @default.
• W2030989871 cites W1591746443 @default.
• W2030989871 cites W1592901199 @default.
• W2030989871 cites W1742701470 @default.
• W2030989871 cites W1749352888 @default.
• W2030989871 cites W1883249023 @default.
• W2030989871 cites W1964839077 @default.
• W2030989871 cites W1983055247 @default.
• W2030989871 cites W1983769449 @default.
• W2030989871 cites W1989854824 @default.
• W2030989871 cites W1993780012 @default.
• W2030989871 cites W1996668125 @default.
• W2030989871 cites W2020200674 @default.
• W2030989871 cites W2021061221 @default.
• W2030989871 cites W2024436009 @default.
• W2030989871 cites W2025308343 @default.
• W2030989871 cites W2036009757 @default.
• W2030989871 cites W2039311072 @default.
• W2030989871 cites W2041547469 @default.
• W2030989871 cites W2041633516 @default.
• W2030989871 cites W2044693162 @default.
• W2030989871 cites W2048185792 @default.
• W2030989871 cites W2048206152 @default.
• W2030989871 cites W2050760725 @default.
• W2030989871 cites W2065365579 @default.
• W2030989871 cites W2073128231 @default.
• W2030989871 cites W2074845717 @default.
• W2030989871 cites W2075217780 @default.
• W2030989871 cites W2075473225 @default.
• W2030989871 cites W2087062134 @default.
• W2030989871 cites W2088337277 @default.
• W2030989871 cites W2100837269 @default.
• W2030989871 cites W2119361029 @default.
• W2030989871 cites W2126440278 @default.
• W2030989871 cites W2203544760 @default.
• W2030989871 doi "https://doi.org/10.1002/(sici)1097-4644(19960101)60:1<121::aid-jcb14>3.0.co;2-s" @default.
• W2030989871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8825421" @default.
• W2030989871 hasPublicationYear "1996" @default.
• W2030989871 type Work @default.
• W2030989871 sameAs 2030989871 @default.
• W2030989871 citedByCount "8" @default.
• W2030989871 countsByYear W20309898712012 @default.
• W2030989871 crossrefType "journal-article" @default.
• W2030989871 hasAuthorship W2030989871A5059926004 @default.
• W2030989871 hasAuthorship W2030989871A5070313655 @default.
• W2030989871 hasConcept C11960822 @default.
• W2030989871 hasConcept C137361374 @default.
• W2030989871 hasConcept C153911025 @default.
• W2030989871 hasConcept C159479382 @default.
• W2030989871 hasConcept C178666793 @default.
• W2030989871 hasConcept C181912034 @default.
• W2030989871 hasConcept C184235292 @default.
• W2030989871 hasConcept C185592680 @default.
• W2030989871 hasConcept C195794163 @default.
• W2030989871 hasConcept C2780245509 @default.
• W2030989871 hasConcept C2781168148 @default.
• W2030989871 hasConcept C42362537 @default.
• W2030989871 hasConcept C55493867 @default.
• W2030989871 hasConcept C59143045 @default.
• W2030989871 hasConcept C62478195 @default.
• W2030989871 hasConcept C82495950 @default.
• W2030989871 hasConcept C86803240 @default.
• W2030989871 hasConcept C90934575 @default.
• W2030989871 hasConcept C95444343 @default.
• W2030989871 hasConcept C97029542 @default.
• W2030989871 hasConceptScore W2030989871C11960822 @default.
• W2030989871 hasConceptScore W2030989871C137361374 @default.
• W2030989871 hasConceptScore W2030989871C153911025 @default.
• W2030989871 hasConceptScore W2030989871C159479382 @default.
• W2030989871 hasConceptScore W2030989871C178666793 @default.
• W2030989871 hasConceptScore W2030989871C181912034 @default.
• W2030989871 hasConceptScore W2030989871C184235292 @default.
• W2030989871 hasConceptScore W2030989871C185592680 @default.
• W2030989871 hasConceptScore W2030989871C195794163 @default.
• W2030989871 hasConceptScore W2030989871C2780245509 @default.
• W2030989871 hasConceptScore W2030989871C2781168148 @default.
• W2030989871 hasConceptScore W2030989871C42362537 @default.
• W2030989871 hasConceptScore W2030989871C55493867 @default.
• W2030989871 hasConceptScore W2030989871C59143045 @default.
• W2030989871 hasConceptScore W2030989871C62478195 @default.
• W2030989871 hasConceptScore W2030989871C82495950 @default.
• W2030989871 hasConceptScore W2030989871C86803240 @default.
• W2030989871 hasConceptScore W2030989871C90934575 @default.
• W2030989871 hasConceptScore W2030989871C95444343 @default.
• W2030989871 hasConceptScore W2030989871C97029542 @default.

• next