Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030989912> ?p ?o ?g. }
- W2030989912 endingPage "207" @default.
- W2030989912 startingPage "199" @default.
- W2030989912 abstract "We investigated the effects of thiorphan, a selective inhibitor of endopeptidase 24.11 'enkephalinase', kelatorphan ((R)-3-(N-hydroxy-carboxamido-2-benzylpropanoyl)-L-alanine), and RB 38 A ((R)-3-(N-hydroxycarboxamido-2-benzylpropanoyl)-L-phenylalanine) two almost complete inhibitors of enkephalin metabolism, on the naloxone-precipitated morphine withdrawal syndrome in rats. Inhibitors administered intracerebroventricularly reduced several symptoms of the withdrawal syndrome. Jumping, chewing and tooth chattering were decreased by all drugs. The rise in plasma corticosterone and the hypothermia were reduced by kelatorphan and RB 38 A whereas rhinorrhea was blocked by thiorphan, tremor by kelatorphan and diarrhoea by RB 38 A. Other signs remained unchanged. These data suggest that an increase in opioid receptor occupancy by endogenous opioid peptides, protected from biotransformation specially by mixed inhibitors reduced the severity of the morphine abstinence symptoms in rats." @default.
- W2030989912 created "2016-06-24" @default.
- W2030989912 creator A5006714076 @default.
- W2030989912 creator A5007324451 @default.
- W2030989912 creator A5032132304 @default.
- W2030989912 creator A5037897982 @default.
- W2030989912 creator A5066614625 @default.
- W2030989912 creator A5068784944 @default.
- W2030989912 creator A5087449124 @default.
- W2030989912 date "1989-06-01" @default.
- W2030989912 modified "2023-10-18" @default.
- W2030989912 title "Comparison of selective and complete inhibitors of enkephalin-degrading enzymes on morphine withdrawal syndrome" @default.
- W2030989912 cites W10899603 @default.
- W2030989912 cites W184031805 @default.
- W2030989912 cites W1965757121 @default.
- W2030989912 cites W1968174216 @default.
- W2030989912 cites W1977647943 @default.
- W2030989912 cites W1978813682 @default.
- W2030989912 cites W1979461216 @default.
- W2030989912 cites W1983585961 @default.
- W2030989912 cites W1992457615 @default.
- W2030989912 cites W1998927581 @default.
- W2030989912 cites W2000997016 @default.
- W2030989912 cites W2001724515 @default.
- W2030989912 cites W2003290955 @default.
- W2030989912 cites W2014128596 @default.
- W2030989912 cites W2032997748 @default.
- W2030989912 cites W2033991110 @default.
- W2030989912 cites W2035294814 @default.
- W2030989912 cites W2037856223 @default.
- W2030989912 cites W2039829114 @default.
- W2030989912 cites W2042190640 @default.
- W2030989912 cites W2044948756 @default.
- W2030989912 cites W2048166249 @default.
- W2030989912 cites W2049704307 @default.
- W2030989912 cites W2052678686 @default.
- W2030989912 cites W2055834690 @default.
- W2030989912 cites W2061585577 @default.
- W2030989912 cites W2069718076 @default.
- W2030989912 cites W2069920566 @default.
- W2030989912 cites W2073908264 @default.
- W2030989912 cites W2074255798 @default.
- W2030989912 cites W2075988101 @default.
- W2030989912 cites W2082513513 @default.
- W2030989912 cites W2093882465 @default.
- W2030989912 cites W2094255968 @default.
- W2030989912 cites W2144168041 @default.
- W2030989912 cites W2314614866 @default.
- W2030989912 cites W4252602539 @default.
- W2030989912 doi "https://doi.org/10.1016/0014-2999(89)90713-9" @default.
- W2030989912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2776828" @default.
- W2030989912 hasPublicationYear "1989" @default.
- W2030989912 type Work @default.
- W2030989912 sameAs 2030989912 @default.
- W2030989912 citedByCount "51" @default.
- W2030989912 countsByYear W20309899122012 @default.
- W2030989912 countsByYear W20309899122013 @default.
- W2030989912 countsByYear W20309899122014 @default.
- W2030989912 countsByYear W20309899122015 @default.
- W2030989912 countsByYear W20309899122016 @default.
- W2030989912 countsByYear W20309899122019 @default.
- W2030989912 countsByYear W20309899122021 @default.
- W2030989912 crossrefType "journal-article" @default.
- W2030989912 hasAuthorship W2030989912A5006714076 @default.
- W2030989912 hasAuthorship W2030989912A5007324451 @default.
- W2030989912 hasAuthorship W2030989912A5032132304 @default.
- W2030989912 hasAuthorship W2030989912A5037897982 @default.
- W2030989912 hasAuthorship W2030989912A5066614625 @default.
- W2030989912 hasAuthorship W2030989912A5068784944 @default.
- W2030989912 hasAuthorship W2030989912A5087449124 @default.
- W2030989912 hasConcept C104826730 @default.
- W2030989912 hasConcept C126322002 @default.
- W2030989912 hasConcept C134018914 @default.
- W2030989912 hasConcept C170493617 @default.
- W2030989912 hasConcept C181199279 @default.
- W2030989912 hasConcept C185592680 @default.
- W2030989912 hasConcept C2777389121 @default.
- W2030989912 hasConcept C2777803847 @default.
- W2030989912 hasConcept C2777972943 @default.
- W2030989912 hasConcept C2778750930 @default.
- W2030989912 hasConcept C2780268870 @default.
- W2030989912 hasConcept C2780919550 @default.
- W2030989912 hasConcept C2781063702 @default.
- W2030989912 hasConcept C2781372283 @default.
- W2030989912 hasConcept C55493867 @default.
- W2030989912 hasConcept C71924100 @default.
- W2030989912 hasConcept C98274493 @default.
- W2030989912 hasConceptScore W2030989912C104826730 @default.
- W2030989912 hasConceptScore W2030989912C126322002 @default.
- W2030989912 hasConceptScore W2030989912C134018914 @default.
- W2030989912 hasConceptScore W2030989912C170493617 @default.
- W2030989912 hasConceptScore W2030989912C181199279 @default.
- W2030989912 hasConceptScore W2030989912C185592680 @default.
- W2030989912 hasConceptScore W2030989912C2777389121 @default.
- W2030989912 hasConceptScore W2030989912C2777803847 @default.
- W2030989912 hasConceptScore W2030989912C2777972943 @default.
- W2030989912 hasConceptScore W2030989912C2778750930 @default.
- W2030989912 hasConceptScore W2030989912C2780268870 @default.