FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030990434> ?p ?o ?g. }

• W2030990434 endingPage "670" @default.
• W2030990434 startingPage "665" @default.
• W2030990434 abstract "Background: Administration of corticosteroids (CS) by different routes may cause varying types of allergic reactions, thereby hampering their further use in affected patients. In order to verify an immunological involvement we evaluated a group of patients with symptoms compatible with nonimmediate allergic reactions to CS. Methods: Studies included patch and intradermal tests, immunohistochemical studies and controlled administration to reproduce the response. The cytokines interleukin (IL)‐4, interferon (IFN)‐ γ and tumor necrosis factor (TNF)‐ α were quantified in peripheral blood during the response. Results: Of 32 subjects evaluated presenting nonimmediate urticaria or exanthema, 21 were finally considered positive after re‐exposure. The drugs most frequently involved were betamethasone and dexamethasone. Fewer than half the patients responded to prednisolone whilst some responded to three or more CS. Hydrocortisone and deflazacort were well tolerated by all the patients. Subjects with a positive intradermal or patch test had a perivascular mononuclear cell infiltrate with the presence of CD4 and CD8 lymphocytes positive for CD45RO+ (memory) and CD69 (activation marker) cells. Monitoring peripheral blood during the acute response showed expression of IFN‐ γ and TNF‐ α , with downregulation of IL‐4. Conclusion: Adverse systemic responses to different CS are suggestive of a nonimmediate reaction. The symptoms elicited together with the immunlogical studies suggest a T‐cell mediated response. The response to closely related CS was especially marked between betamethasone and dexamethasone, whereas hydrocortisone and deflazacort were well tolerated." @default.
• W2030990434 created "2016-06-24" @default.
• W2030990434 creator A5012414218 @default.
• W2030990434 creator A5025929927 @default.
• W2030990434 creator A5048736046 @default.
• W2030990434 creator A5060966579 @default.
• W2030990434 creator A5064851701 @default.
• W2030990434 creator A5084503790 @default.
• W2030990434 date "2005-04-06" @default.
• W2030990434 modified "2023-10-16" @default.
• W2030990434 title "Nonimmediate reactions to systemic corticosteroids suggest an immunological mechanism" @default.
• W2030990434 cites W1481537523 @default.
• W2030990434 cites W1516728281 @default.
• W2030990434 cites W1609782222 @default.
• W2030990434 cites W1717444875 @default.
• W2030990434 cites W1827458933 @default.
• W2030990434 cites W1951353479 @default.
• W2030990434 cites W1979591626 @default.
• W2030990434 cites W1980377909 @default.
• W2030990434 cites W2001805749 @default.
• W2030990434 cites W2004052289 @default.
• W2030990434 cites W2036425689 @default.
• W2030990434 cites W2040062648 @default.
• W2030990434 cites W2040954737 @default.
• W2030990434 cites W2045470958 @default.
• W2030990434 cites W2046744107 @default.
• W2030990434 cites W2072549117 @default.
• W2030990434 cites W2092028314 @default.
• W2030990434 cites W2094557962 @default.
• W2030990434 cites W2098176385 @default.
• W2030990434 cites W2109018114 @default.
• W2030990434 cites W2121812959 @default.
• W2030990434 cites W2124621614 @default.
• W2030990434 cites W2126189498 @default.
• W2030990434 cites W4301466000 @default.
• W2030990434 cites W4313335077 @default.
• W2030990434 doi "https://doi.org/10.1111/j.1398-9995.2005.00749.x" @default.
• W2030990434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15813813" @default.
• W2030990434 hasPublicationYear "2005" @default.
• W2030990434 type Work @default.
• W2030990434 sameAs 2030990434 @default.
• W2030990434 citedByCount "31" @default.
• W2030990434 countsByYear W20309904342012 @default.
• W2030990434 countsByYear W20309904342013 @default.
• W2030990434 countsByYear W20309904342014 @default.
• W2030990434 countsByYear W20309904342016 @default.
• W2030990434 countsByYear W20309904342019 @default.
• W2030990434 countsByYear W20309904342020 @default.
• W2030990434 countsByYear W20309904342021 @default.
• W2030990434 crossrefType "journal-article" @default.
• W2030990434 hasAuthorship W2030990434A5012414218 @default.
• W2030990434 hasAuthorship W2030990434A5025929927 @default.
• W2030990434 hasAuthorship W2030990434A5048736046 @default.
• W2030990434 hasAuthorship W2030990434A5060966579 @default.
• W2030990434 hasAuthorship W2030990434A5064851701 @default.
• W2030990434 hasAuthorship W2030990434A5084503790 @default.
• W2030990434 hasConcept C126322002 @default.
• W2030990434 hasConcept C137061746 @default.
• W2030990434 hasConcept C167672396 @default.
• W2030990434 hasConcept C17991360 @default.
• W2030990434 hasConcept C185592680 @default.
• W2030990434 hasConcept C202751555 @default.
• W2030990434 hasConcept C203014093 @default.
• W2030990434 hasConcept C207480886 @default.
• W2030990434 hasConcept C2776376305 @default.
• W2030990434 hasConcept C2776715498 @default.
• W2030990434 hasConcept C2776804153 @default.
• W2030990434 hasConcept C2778690821 @default.
• W2030990434 hasConcept C2778709874 @default.
• W2030990434 hasConcept C2780401358 @default.
• W2030990434 hasConcept C2781162121 @default.
• W2030990434 hasConcept C55493867 @default.
• W2030990434 hasConcept C71924100 @default.
• W2030990434 hasConcept C74172505 @default.
• W2030990434 hasConcept C8891405 @default.
• W2030990434 hasConceptScore W2030990434C126322002 @default.
• W2030990434 hasConceptScore W2030990434C137061746 @default.
• W2030990434 hasConceptScore W2030990434C167672396 @default.
• W2030990434 hasConceptScore W2030990434C17991360 @default.
• W2030990434 hasConceptScore W2030990434C185592680 @default.
• W2030990434 hasConceptScore W2030990434C202751555 @default.
• W2030990434 hasConceptScore W2030990434C203014093 @default.
• W2030990434 hasConceptScore W2030990434C207480886 @default.
• W2030990434 hasConceptScore W2030990434C2776376305 @default.
• W2030990434 hasConceptScore W2030990434C2776715498 @default.
• W2030990434 hasConceptScore W2030990434C2776804153 @default.
• W2030990434 hasConceptScore W2030990434C2778690821 @default.
• W2030990434 hasConceptScore W2030990434C2778709874 @default.
• W2030990434 hasConceptScore W2030990434C2780401358 @default.
• W2030990434 hasConceptScore W2030990434C2781162121 @default.
• W2030990434 hasConceptScore W2030990434C55493867 @default.
• W2030990434 hasConceptScore W2030990434C71924100 @default.
• W2030990434 hasConceptScore W2030990434C74172505 @default.
• W2030990434 hasConceptScore W2030990434C8891405 @default.
• W2030990434 hasIssue "5" @default.
• W2030990434 hasLocation W20309904341 @default.
• W2030990434 hasLocation W20309904342 @default.
• W2030990434 hasOpenAccess W2030990434 @default.

• next