Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030991115> ?p ?o ?g. }
- W2030991115 endingPage "1670" @default.
- W2030991115 startingPage "1663" @default.
- W2030991115 abstract "Although the accepted standard of care during the induction treatment of active lupus nephritis (LN) has been cyclophosphamide (CYC), recent trials suggest that calcineurin inhibitors (CNIs), which include cyclosporine A (CsA) and tacrolimus (TAC), may be just as, or even more, effective and less toxic than CYC. A systematic review and meta-analysis were performed to evaluate the clinical effects of CNIs on active LN compared with those of CYC. In the present study, clinical trials that compared CNIs with CYC in the induction therapy of active LN were searched in the Cochrane Library, Ovid and PubMed databases. The clinical data on renal remission and side-effects were collected and analyzed. The relative risk (RR) and 95% confidence intervals (CIs) were calculated. As a result, six controlled trials involving 265 patients were included in the meta-analysis, four of which compared TAC (treatment group) with CYC (control group), and the other two compared CsA (treatment group) with CYC (control group). CNIs were superior to CYC for higher complete remission (RR=1.56, 95% CI 1.14‑2.15, Z=2.74, P=0.006) and better overall response/total remission (RR=1.23, 95% CI 1.07‑1.42, Z=2.87, P=0.004) and had fewer side‑effects. Among the CNIs, TAC demonstrated more favorable results than CsA. Therefore, it was concluded that CNIs may be a reasonable alternative to CYC in the induction treatment of active LN. However, large-scale, multicenter, well-designed clinical trials should be adopted to further confirm this conclusion." @default.
- W2030991115 created "2016-06-24" @default.
- W2030991115 creator A5001372636 @default.
- W2030991115 creator A5024446075 @default.
- W2030991115 creator A5024525336 @default.
- W2030991115 creator A5024611619 @default.
- W2030991115 creator A5066637687 @default.
- W2030991115 date "2014-04-07" @default.
- W2030991115 modified "2023-10-18" @default.
- W2030991115 title "Calcineurin inhibitors may be a reasonable alternative to cyclophosphamide in the induction treatment of active lupus nephritis: A systematic review and meta-analysis" @default.
- W2030991115 cites W1770551292 @default.
- W2030991115 cites W1971058219 @default.
- W2030991115 cites W1986215651 @default.
- W2030991115 cites W1990536034 @default.
- W2030991115 cites W1993619587 @default.
- W2030991115 cites W1996592861 @default.
- W2030991115 cites W2002817089 @default.
- W2030991115 cites W2005485701 @default.
- W2030991115 cites W2015609157 @default.
- W2030991115 cites W2022473731 @default.
- W2030991115 cites W2039111599 @default.
- W2030991115 cites W2039280807 @default.
- W2030991115 cites W2045992760 @default.
- W2030991115 cites W2046088757 @default.
- W2030991115 cites W2049142512 @default.
- W2030991115 cites W2050600589 @default.
- W2030991115 cites W2053582855 @default.
- W2030991115 cites W2060671195 @default.
- W2030991115 cites W2074016776 @default.
- W2030991115 cites W2082428789 @default.
- W2030991115 cites W2082892740 @default.
- W2030991115 cites W2088942316 @default.
- W2030991115 cites W2090256056 @default.
- W2030991115 cites W2103899236 @default.
- W2030991115 cites W2113709196 @default.
- W2030991115 cites W2117294447 @default.
- W2030991115 cites W2118080440 @default.
- W2030991115 cites W2118914856 @default.
- W2030991115 cites W2126930838 @default.
- W2030991115 cites W2133264060 @default.
- W2030991115 cites W2134338262 @default.
- W2030991115 cites W2148306888 @default.
- W2030991115 cites W2149686068 @default.
- W2030991115 cites W2152568614 @default.
- W2030991115 cites W2325870812 @default.
- W2030991115 cites W4250535683 @default.
- W2030991115 doi "https://doi.org/10.3892/etm.2014.1669" @default.
- W2030991115 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4043578" @default.
- W2030991115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24926363" @default.
- W2030991115 hasPublicationYear "2014" @default.
- W2030991115 type Work @default.
- W2030991115 sameAs 2030991115 @default.
- W2030991115 citedByCount "15" @default.
- W2030991115 countsByYear W20309911152015 @default.
- W2030991115 countsByYear W20309911152016 @default.
- W2030991115 countsByYear W20309911152017 @default.
- W2030991115 crossrefType "journal-article" @default.
- W2030991115 hasAuthorship W2030991115A5001372636 @default.
- W2030991115 hasAuthorship W2030991115A5024446075 @default.
- W2030991115 hasAuthorship W2030991115A5024525336 @default.
- W2030991115 hasAuthorship W2030991115A5024611619 @default.
- W2030991115 hasAuthorship W2030991115A5066637687 @default.
- W2030991115 hasBestOaLocation W20309911151 @default.
- W2030991115 hasConcept C126322002 @default.
- W2030991115 hasConcept C128057223 @default.
- W2030991115 hasConcept C143998085 @default.
- W2030991115 hasConcept C168563851 @default.
- W2030991115 hasConcept C2776478404 @default.
- W2030991115 hasConcept C2776694085 @default.
- W2030991115 hasConcept C2776755627 @default.
- W2030991115 hasConcept C2779134260 @default.
- W2030991115 hasConcept C2779912601 @default.
- W2030991115 hasConcept C2911091166 @default.
- W2030991115 hasConcept C44249647 @default.
- W2030991115 hasConcept C71924100 @default.
- W2030991115 hasConcept C82789193 @default.
- W2030991115 hasConcept C95190672 @default.
- W2030991115 hasConcept C98274493 @default.
- W2030991115 hasConceptScore W2030991115C126322002 @default.
- W2030991115 hasConceptScore W2030991115C128057223 @default.
- W2030991115 hasConceptScore W2030991115C143998085 @default.
- W2030991115 hasConceptScore W2030991115C168563851 @default.
- W2030991115 hasConceptScore W2030991115C2776478404 @default.
- W2030991115 hasConceptScore W2030991115C2776694085 @default.
- W2030991115 hasConceptScore W2030991115C2776755627 @default.
- W2030991115 hasConceptScore W2030991115C2779134260 @default.
- W2030991115 hasConceptScore W2030991115C2779912601 @default.
- W2030991115 hasConceptScore W2030991115C2911091166 @default.
- W2030991115 hasConceptScore W2030991115C44249647 @default.
- W2030991115 hasConceptScore W2030991115C71924100 @default.
- W2030991115 hasConceptScore W2030991115C82789193 @default.
- W2030991115 hasConceptScore W2030991115C95190672 @default.
- W2030991115 hasConceptScore W2030991115C98274493 @default.
- W2030991115 hasIssue "6" @default.
- W2030991115 hasLocation W20309911151 @default.
- W2030991115 hasLocation W20309911152 @default.
- W2030991115 hasLocation W20309911153 @default.
- W2030991115 hasLocation W20309911154 @default.