FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030993461> ?p ?o ?g. }

• W2030993461 endingPage "250" @default.
• W2030993461 startingPage "238" @default.
• W2030993461 abstract "In recent years microspheres or microparticles produced from biodegradable polymers such as poly(d,l-lactide) (PLA) and poly(d,l-lactide-co-glycolide) (PLGA) containing encapsulated vaccine antigens have been investigated for administration via parenteral, oral, and intranasal routes. These microparticles allow the controlled release of vaccines with an aim to reduce the number of doses for primary immunisation or to develop single dose vaccines. The polymer materials have been widely regarded as being of minimal toxicity. Evaluation of candidate systems in animal studies have shown antibody levels and cell responses similar to or greater than those observed with adjuvants such as alum. However, there are concerns regarding the integrity and immunogenicity of the antigen during the encapsulation process when the antigen is exposed to organic solvents, high shear stresses and the exposure of antigen to low pH which is caused by polymer degradation. An alternative approach would be to adsorb antigens to the surface of biodegradable polymer particles. Polymeric lamellar substrate particles (PLSP), produced by a simple precipitation of PLA, are suitable for this purpose. The adsorption of antigens onto these particles is a simple procedure. It avoids pH changes due to bulk polymer degradation and the use of solvents and therefore will be less damaging to the vaccine. Moreover, such systems will be much easier to scale up for a clinical study and eventual manufacture. The aim of this article is to discuss the preparation and physical characteristics of PLSP, antigen adsorption, in vivo efficacy of PLSP antigen systems and to consider the potential of PLSP as controlled release adjuvants for protein, peptide or viral vaccines." @default.
• W2030993461 created "2016-06-24" @default.
• W2030993461 creator A5022727810 @default.
• W2030993461 creator A5030237607 @default.
• W2030993461 creator A5032429649 @default.
• W2030993461 creator A5033638346 @default.
• W2030993461 creator A5053275173 @default.
• W2030993461 creator A5055954907 @default.
• W2030993461 creator A5057809897 @default.
• W2030993461 creator A5064994129 @default.
• W2030993461 creator A5073269960 @default.
• W2030993461 creator A5080592111 @default.
• W2030993461 creator A5082654662 @default.
• W2030993461 creator A5083779664 @default.
• W2030993461 creator A5089810948 @default.
• W2030993461 date "1999-09-01" @default.
• W2030993461 modified "2023-09-26" @default.
• W2030993461 title "Potential of polymeric lamellar substrate particles (PLSP) as adjuvants for vaccines" @default.
• W2030993461 cites W1512372117 @default.
• W2030993461 cites W1564933160 @default.
• W2030993461 cites W1582227496 @default.
• W2030993461 cites W1607679832 @default.
• W2030993461 cites W1968509653 @default.
• W2030993461 cites W1974088843 @default.
• W2030993461 cites W1974536984 @default.
• W2030993461 cites W1975133899 @default.
• W2030993461 cites W1977437107 @default.
• W2030993461 cites W1985656444 @default.
• W2030993461 cites W1989498696 @default.
• W2030993461 cites W1989908697 @default.
• W2030993461 cites W1992497253 @default.
• W2030993461 cites W1997596842 @default.
• W2030993461 cites W2000908785 @default.
• W2030993461 cites W2007269463 @default.
• W2030993461 cites W2012260545 @default.
• W2030993461 cites W2012672452 @default.
• W2030993461 cites W2015639818 @default.
• W2030993461 cites W2018082716 @default.
• W2030993461 cites W2027111014 @default.
• W2030993461 cites W2031079435 @default.
• W2030993461 cites W2036520352 @default.
• W2030993461 cites W2038018703 @default.
• W2030993461 cites W2039725447 @default.
• W2030993461 cites W2043920860 @default.
• W2030993461 cites W2049428621 @default.
• W2030993461 cites W2057263702 @default.
• W2030993461 cites W2060836244 @default.
• W2030993461 cites W2064984880 @default.
• W2030993461 cites W2072245133 @default.
• W2030993461 cites W2077637808 @default.
• W2030993461 cites W2080667413 @default.
• W2030993461 cites W2080942679 @default.
• W2030993461 cites W2085731798 @default.
• W2030993461 cites W2128369741 @default.
• W2030993461 cites W2132431972 @default.
• W2030993461 cites W2139222824 @default.
• W2030993461 cites W2158665346 @default.
• W2030993461 cites W2163050347 @default.
• W2030993461 cites W2166570105 @default.
• W2030993461 cites W2332423443 @default.
• W2030993461 cites W261734212 @default.
• W2030993461 cites W4244506835 @default.
• W2030993461 cites W4247377398 @default.
• W2030993461 cites W4313315440 @default.
• W2030993461 doi "https://doi.org/10.1016/s0264-410x(99)00195-4" @default.
• W2030993461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10506648" @default.
• W2030993461 hasPublicationYear "1999" @default.
• W2030993461 type Work @default.
• W2030993461 sameAs 2030993461 @default.
• W2030993461 citedByCount "46" @default.
• W2030993461 countsByYear W20309934612012 @default.
• W2030993461 countsByYear W20309934612013 @default.
• W2030993461 countsByYear W20309934612014 @default.
• W2030993461 countsByYear W20309934612015 @default.
• W2030993461 countsByYear W20309934612019 @default.
• W2030993461 countsByYear W20309934612020 @default.
• W2030993461 crossrefType "journal-article" @default.
• W2030993461 hasAuthorship W2030993461A5022727810 @default.
• W2030993461 hasAuthorship W2030993461A5030237607 @default.
• W2030993461 hasAuthorship W2030993461A5032429649 @default.
• W2030993461 hasAuthorship W2030993461A5033638346 @default.
• W2030993461 hasAuthorship W2030993461A5053275173 @default.
• W2030993461 hasAuthorship W2030993461A5055954907 @default.
• W2030993461 hasAuthorship W2030993461A5057809897 @default.
• W2030993461 hasAuthorship W2030993461A5064994129 @default.
• W2030993461 hasAuthorship W2030993461A5073269960 @default.
• W2030993461 hasAuthorship W2030993461A5080592111 @default.
• W2030993461 hasAuthorship W2030993461A5082654662 @default.
• W2030993461 hasAuthorship W2030993461A5083779664 @default.
• W2030993461 hasAuthorship W2030993461A5089810948 @default.
• W2030993461 hasConcept C147483822 @default.
• W2030993461 hasConcept C150394285 @default.
• W2030993461 hasConcept C155672457 @default.
• W2030993461 hasConcept C171250308 @default.
• W2030993461 hasConcept C178790620 @default.
• W2030993461 hasConcept C185592680 @default.
• W2030993461 hasConcept C192562407 @default.
• W2030993461 hasConcept C203014093 @default.

• next