Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030996838> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2030996838 endingPage "316" @default.
- W2030996838 startingPage "307" @default.
- W2030996838 abstract "Primary brain tumours are a major cause of cancerrelated morbidity and mortality in the United States. Despite the development of aggressive multi-modality therapy regimens, median survivals for patients with these malignancies remain poor (1). Surgery followed by radiation therapy increases survival from a median of 14 weeks with surgery alone to 35-48 weeks when followed by radiation (2). Multimodality therapy including chemotherapy is the standard clinical approach in many centers in the U.S., although the addition of cytotoxic chemotherapy to the treatment regimen has only a modest effect on median survival. A recent meta-analysis showed that adding chemotherapy to surgery and radiation improved the median survival duration from 9.4 to 12 months (3). At present, the nitrosoureas, particularly carmustine (BCNU) and lomustine (CCNU), are the most frequently used agents in primary brain tumors (4). These drugs are highly lipid soluble, readily cross the blood-brain barrier and are considered among the most effective against these tumours. In recurrent glioma, the response data are difficult to interpret owing to heterogeneity in clinical trials and the use of varying response criteria. Nonetheless, objective response rates for patients with recurrent high grade glioma treated with BCNU are reported to range from 2030% (4). Unfortunately, these statistics are based on a number of studies conducted before the availability of computerized tomography (CT). Few studies exist which examine other single-agent therapies for recurrent glioma. Some of the other chemotherapeutic" @default.
- W2030996838 created "2016-06-24" @default.
- W2030996838 creator A5006086380 @default.
- W2030996838 creator A5056654709 @default.
- W2030996838 creator A5072807270 @default.
- W2030996838 date "1998-10-01" @default.
- W2030996838 modified "2023-09-23" @default.
- W2030996838 title "Platinum analogues in the treatment of recurrent high grade astrocytoma" @default.
- W2030996838 cites W1579641819 @default.
- W2030996838 cites W1847381023 @default.
- W2030996838 cites W1944104521 @default.
- W2030996838 cites W1966978209 @default.
- W2030996838 cites W1971320685 @default.
- W2030996838 cites W1972011430 @default.
- W2030996838 cites W2001417910 @default.
- W2030996838 cites W2002464801 @default.
- W2030996838 cites W2013409724 @default.
- W2030996838 cites W2022316171 @default.
- W2030996838 cites W2025881070 @default.
- W2030996838 cites W2036560693 @default.
- W2030996838 cites W2064542358 @default.
- W2030996838 cites W2071434086 @default.
- W2030996838 cites W2088925558 @default.
- W2030996838 cites W2143507718 @default.
- W2030996838 cites W2227545313 @default.
- W2030996838 cites W2304355572 @default.
- W2030996838 cites W2334626003 @default.
- W2030996838 cites W2419435391 @default.
- W2030996838 cites W27277497 @default.
- W2030996838 cites W2884633475 @default.
- W2030996838 cites W2290326436 @default.
- W2030996838 doi "https://doi.org/10.1016/s0305-7372(98)90054-8" @default.
- W2030996838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9861194" @default.
- W2030996838 hasPublicationYear "1998" @default.
- W2030996838 type Work @default.
- W2030996838 sameAs 2030996838 @default.
- W2030996838 citedByCount "15" @default.
- W2030996838 countsByYear W20309968382014 @default.
- W2030996838 countsByYear W20309968382015 @default.
- W2030996838 countsByYear W20309968382020 @default.
- W2030996838 countsByYear W20309968382022 @default.
- W2030996838 crossrefType "journal-article" @default.
- W2030996838 hasAuthorship W2030996838A5006086380 @default.
- W2030996838 hasAuthorship W2030996838A5056654709 @default.
- W2030996838 hasAuthorship W2030996838A5072807270 @default.
- W2030996838 hasConcept C126322002 @default.
- W2030996838 hasConcept C143998085 @default.
- W2030996838 hasConcept C161790260 @default.
- W2030996838 hasConcept C185592680 @default.
- W2030996838 hasConcept C2776194525 @default.
- W2030996838 hasConcept C2778880634 @default.
- W2030996838 hasConcept C502942594 @default.
- W2030996838 hasConcept C518104683 @default.
- W2030996838 hasConcept C55493867 @default.
- W2030996838 hasConcept C71924100 @default.
- W2030996838 hasConceptScore W2030996838C126322002 @default.
- W2030996838 hasConceptScore W2030996838C143998085 @default.
- W2030996838 hasConceptScore W2030996838C161790260 @default.
- W2030996838 hasConceptScore W2030996838C185592680 @default.
- W2030996838 hasConceptScore W2030996838C2776194525 @default.
- W2030996838 hasConceptScore W2030996838C2778880634 @default.
- W2030996838 hasConceptScore W2030996838C502942594 @default.
- W2030996838 hasConceptScore W2030996838C518104683 @default.
- W2030996838 hasConceptScore W2030996838C55493867 @default.
- W2030996838 hasConceptScore W2030996838C71924100 @default.
- W2030996838 hasIssue "5" @default.
- W2030996838 hasLocation W20309968381 @default.
- W2030996838 hasLocation W20309968382 @default.
- W2030996838 hasOpenAccess W2030996838 @default.
- W2030996838 hasPrimaryLocation W20309968381 @default.
- W2030996838 hasRelatedWork W1991038948 @default.
- W2030996838 hasRelatedWork W1996834303 @default.
- W2030996838 hasRelatedWork W2075324522 @default.
- W2030996838 hasRelatedWork W2077444423 @default.
- W2030996838 hasRelatedWork W2515755848 @default.
- W2030996838 hasRelatedWork W2897496508 @default.
- W2030996838 hasRelatedWork W2914805322 @default.
- W2030996838 hasRelatedWork W2954397531 @default.
- W2030996838 hasRelatedWork W4239002430 @default.
- W2030996838 hasRelatedWork W4240702278 @default.
- W2030996838 hasVolume "24" @default.
- W2030996838 isParatext "false" @default.
- W2030996838 isRetracted "false" @default.
- W2030996838 magId "2030996838" @default.
- W2030996838 workType "article" @default.