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• W2031001451 abstract "Abstract The selectivity of the nucleoside bases in RNA transcription can be inferred, in principle, from the DNA base pair-RNA base interaction. The catalytic role of enzymes is, therefore, only to form the sugar phosphate backbone. A systematic study for the evaluation of interaction energy of the DNA base pair with the entrant RNA bases was undertaken to elucidate the aforesaid mechanism. The mechanism was extended to modified bases and a model for the incorporation of nucleoside analogues is proposed. The biological significance of the results is discussed. This model is useful in predicting the inhibitory action, order of activity and particular specificity of the analogous nucleoside base in the nucleic acid chain." @default.
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• W2031001451 date "1991-09-01" @default.
• W2031001451 modified "2023-09-27" @default.
• W2031001451 title "Specificity of transcription and incorporation of nucleoside analogues" @default.
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• W2031001451 doi "https://doi.org/10.1016/0166-1280(91)85067-h" @default.
• W2031001451 hasPublicationYear "1991" @default.
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