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- W2031002037 abstract "Abstract Surface modification of dental implants with biomolecules is of particularly interest recently. To mimic the structure and function of native extracellular matrix (ECM), a derivative of hyaluronic acid (HA), HA–GRGDSP, was synthesized, Arg–Gly–Asp (RGD)‐containing collagen (Col)/HA multilayer polyelectrolyte films (MPFs) coating was fabricated on titanium (Ti) through alternate deposition of Col and HA–GRGDSP with 4.5 assembly cycles; moreover, bioactive molecule, basic fibroblast growth factor (bFGF), was also incorporated into such coating. This coating was then carefully characterized using scanning electronic microscope (SEM) and scanning force microscopy (SFM); bFGF release from the coating was also evaluated. (Col + bFGF)/HA–RGD coating was successfully deposited on Ti surface, and about 300 pg of bFGF could be slowly released from this coating for a week. This coating significantly promoted the initial cell attachment of human gingival fibroblasts (HGFs) compared with other groups ( p < 0.05), and HGFs adhered and spread better on this coating than other groups ( p < 0.05). Regarding cell proliferation and differentiation of HGFs, they were greatly stimulated when cultured on this coating ( p < 0.05). These results indicated that surface modification of Ti using biomolecules might improve the sealing between the neck section of a dental implant and the soft tissue. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012." @default.
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- W2031002037 date "2012-08-22" @default.
- W2031002037 modified "2023-10-16" @default.
- W2031002037 title "Enhanced attachment, proliferation, and differentiation of human gingival fibroblasts on titanium surface modified with biomolecules" @default.
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- W2031002037 doi "https://doi.org/10.1002/jbm.b.32784" @default.
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