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- W2031004837 abstract "Rounded-amoeboid cancer cells use actomyosin contractility driven by Rho-ROCK and JAK-STAT3 to migrate efficiently. It has been suggested that rounded-amoeboid cancer cells do not require matrix metalloproteinases (MMPs) to invade. Here we compare MMP levels in rounded-amoeboid and elongated-mesenchymal melanoma cells. Surprisingly, we find that rounded-amoeboid melanoma cells secrete higher levels of several MMPs, including collagenase MMP-13 and gelatinase MMP-9. As a result, rounded-amoeboid melanoma cells degrade collagen I more efficiently than elongated-mesenchymal cells. Furthermore, using a non-catalytic mechanism, MMP-9 promotes rounded-amoeboid 3D migration through regulation of actomyosin contractility via CD44 receptor. MMP-9 is upregulated in a panel of rounded-amoeboid compared with elongated-mesenchymal melanoma cell lines and its levels are controlled by ROCK-JAK-STAT3 signalling. MMP-9 expression increases during melanoma progression and it is particularly prominent in the invasive fronts of lesions, correlating with cell roundness. Therefore, rounded-amoeboid cells use both catalytic and non-catalytic activities of MMPs for invasion." @default.
- W2031004837 created "2016-06-24" @default.
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- W2031004837 date "2014-06-25" @default.
- W2031004837 modified "2023-10-14" @default.
- W2031004837 title "Diverse matrix metalloproteinase functions regulate cancer amoeboid migration" @default.
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- W2031004837 doi "https://doi.org/10.1038/ncomms5255" @default.
- W2031004837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4118761" @default.
- W2031004837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24963846" @default.
- W2031004837 hasPublicationYear "2014" @default.
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