FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031031595> ?p ?o ?g. }

• W2031031595 endingPage "422" @default.
• W2031031595 startingPage "415" @default.
• W2031031595 abstract "Healthy volunteers (n = 50) were enrolled for studying the variation of gene expression induced by smoking in peripheral lymphocytes. RNAs from smokers (> 3 cigarettes/day, n = 20) and passive smokers (exposed to tobacco smoke > 3 h/day, n = 10) were hybridized versus a reference pool obtained by mixing equal amounts of RNA from 20 nonsmokers, and gene expression was analyzed using DNA microarrays containing 13,971 oligos. Principal component analysis showed that 99.7% of gene expression variability was related to plasma cotinine, age, and DNA oxidation damage. SAM and GenMAPP/MAPPFinder analyses showed that smokers, compared to nonsmokers, had 129 down-regulated and 87 up-regulated genes, whereas passive smokers, compared to nonsmokers, had 44 down-regulated and 159 up-regulated genes, mainly involved in pathways associated with the activation of defensive responses. Hierarchical cluster analysis identified two distinct clusters of smokers, characterized by different oxidative DNA damage: smokers with high DNA oxidation damage, compared to smokers with low DNA oxidation damage, had a large number (150) of down-regulated genes, mainly associated with xenobiotic metabolism, DNA damage and repair, inflammatory responses, lymphocyte activation, and cytokine activity, suggesting a reduced cellular response to toxic agents in this subset of smokers that could lead to an increased DNA oxidation damage." @default.
• W2031031595 created "2016-06-24" @default.
• W2031031595 creator A5006094365 @default.
• W2031031595 creator A5011722531 @default.
• W2031031595 creator A5014298845 @default.
• W2031031595 creator A5018115091 @default.
• W2031031595 creator A5029974417 @default.
• W2031031595 creator A5082717632 @default.
• W2031031595 date "2007-08-01" @default.
• W2031031595 modified "2023-09-25" @default.
• W2031031595 title "Smokers and passive smokers gene expression profiles: Correlation with the DNA oxidation damage" @default.
• W2031031595 cites W1513618424 @default.
• W2031031595 cites W1887281585 @default.
• W2031031595 cites W1966424551 @default.
• W2031031595 cites W1991685549 @default.
• W2031031595 cites W1992978140 @default.
• W2031031595 cites W2009766515 @default.
• W2031031595 cites W2012382065 @default.
• W2031031595 cites W2013815934 @default.
• W2031031595 cites W2016296894 @default.
• W2031031595 cites W2026038326 @default.
• W2031031595 cites W2032531160 @default.
• W2031031595 cites W2037918486 @default.
• W2031031595 cites W2052750543 @default.
• W2031031595 cites W2053375738 @default.
• W2031031595 cites W2060620036 @default.
• W2031031595 cites W2079931352 @default.
• W2031031595 cites W2082880363 @default.
• W2031031595 cites W2108810039 @default.
• W2031031595 cites W2112472493 @default.
• W2031031595 cites W2113478190 @default.
• W2031031595 cites W2115786720 @default.
• W2031031595 cites W2126944598 @default.
• W2031031595 cites W2130064337 @default.
• W2031031595 cites W2141051547 @default.
• W2031031595 cites W2141249815 @default.
• W2031031595 cites W2147178029 @default.
• W2031031595 cites W2157795344 @default.
• W2031031595 cites W2160242894 @default.
• W2031031595 cites W2161823547 @default.
• W2031031595 cites W2188961409 @default.
• W2031031595 cites W2259426851 @default.
• W2031031595 cites W2397360403 @default.
• W2031031595 cites W37545008 @default.
• W2031031595 cites W82539334 @default.
• W2031031595 doi "https://doi.org/10.1016/j.freeradbiomed.2007.04.018" @default.
• W2031031595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17602957" @default.
• W2031031595 hasPublicationYear "2007" @default.
• W2031031595 type Work @default.
• W2031031595 sameAs 2031031595 @default.
• W2031031595 citedByCount "26" @default.
• W2031031595 countsByYear W20310315952012 @default.
• W2031031595 countsByYear W20310315952015 @default.
• W2031031595 countsByYear W20310315952017 @default.
• W2031031595 countsByYear W20310315952018 @default.
• W2031031595 countsByYear W20310315952020 @default.
• W2031031595 countsByYear W20310315952021 @default.
• W2031031595 countsByYear W20310315952022 @default.
• W2031031595 crossrefType "journal-article" @default.
• W2031031595 hasAuthorship W2031031595A5006094365 @default.
• W2031031595 hasAuthorship W2031031595A5011722531 @default.
• W2031031595 hasAuthorship W2031031595A5014298845 @default.
• W2031031595 hasAuthorship W2031031595A5018115091 @default.
• W2031031595 hasAuthorship W2031031595A5029974417 @default.
• W2031031595 hasAuthorship W2031031595A5082717632 @default.
• W2031031595 hasConcept C104317684 @default.
• W2031031595 hasConcept C143425029 @default.
• W2031031595 hasConcept C150194340 @default.
• W2031031595 hasConcept C153911025 @default.
• W2031031595 hasConcept C185592680 @default.
• W2031031595 hasConcept C186836561 @default.
• W2031031595 hasConcept C54355233 @default.
• W2031031595 hasConcept C552990157 @default.
• W2031031595 hasConcept C86803240 @default.
• W2031031595 hasConcept C95371953 @default.
• W2031031595 hasConceptScore W2031031595C104317684 @default.
• W2031031595 hasConceptScore W2031031595C143425029 @default.
• W2031031595 hasConceptScore W2031031595C150194340 @default.
• W2031031595 hasConceptScore W2031031595C153911025 @default.
• W2031031595 hasConceptScore W2031031595C185592680 @default.
• W2031031595 hasConceptScore W2031031595C186836561 @default.
• W2031031595 hasConceptScore W2031031595C54355233 @default.
• W2031031595 hasConceptScore W2031031595C552990157 @default.
• W2031031595 hasConceptScore W2031031595C86803240 @default.
• W2031031595 hasConceptScore W2031031595C95371953 @default.
• W2031031595 hasIssue "3" @default.
• W2031031595 hasLocation W20310315951 @default.
• W2031031595 hasLocation W20310315952 @default.
• W2031031595 hasOpenAccess W2031031595 @default.
• W2031031595 hasPrimaryLocation W20310315951 @default.
• W2031031595 hasRelatedWork W2006024165 @default.
• W2031031595 hasRelatedWork W2021297725 @default.
• W2031031595 hasRelatedWork W2053053668 @default.
• W2031031595 hasRelatedWork W2117264420 @default.
• W2031031595 hasRelatedWork W2360416811 @default.
• W2031031595 hasRelatedWork W2362947020 @default.
• W2031031595 hasRelatedWork W2363311673 @default.
• W2031031595 hasRelatedWork W2385534162 @default.

• next