FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031036478> ?p ?o ?g. }

• W2031036478 endingPage "H458" @default.
• W2031036478 startingPage "H451" @default.
• W2031036478 abstract "While macrophages take up modified LDL to form foam cells and multiply to develop fatty streaks, vascular smooth muscle cells (VSMC) migrate from the media to intima, secrete extracellular matrix, and increase the volume of atherosclerotic lesions. A medicinal plant Garcinia dulcis has been used in traditional Thai medicine for centuries to treat various chronic human diseases. Morelloflavone, a biflavonoid and an active ingredient of the plant, has been shown to inhibit VSMC migration through its inhibition of multiple migration-related kinases such as focal adhesion kinase, c-Src, ERK, and RhoA. However, the exact role of morelloflavone in atherosclerogenesis was unknown. We fed Ldlr −/− Apobec1 −/− mice with either normal chow or chow containing 0.003% morelloflavone for 8 mo and assessed the extent of atherosclerosis by the en face and cross-sectional analyses. A cell composition analysis of atherosclerotic tissue was carried out using immunohistochemical staining. Oral morelloflavone therapy significantly reduced the atherosclerotic areas of the mouse aortas (a 26% reduction), without changing plasma lipid profiles or weights. Immunohistochemical analyses showed that morelloflavone reduced the number of VSMC in the atherosclerotic lesion while it did not change the density of macrophages in the lesion or the percentages of proliferating and apoptotic cells. Oral, low-dose, morelloflavone therapy retards atherosclerogenesis by limiting the migration of VSMC into the intima in the mouse model of human atherosclerosis. Upon further investigation, morelloflavone may be found to be a novel oral antiatherosclerotic agent and a viable addition to the conventional therapies such as statins in humans." @default.
• W2031036478 created "2016-06-24" @default.
• W2031036478 creator A5014472905 @default.
• W2031036478 creator A5016774211 @default.
• W2031036478 creator A5021123195 @default.
• W2031036478 creator A5043599549 @default.
• W2031036478 creator A5055523921 @default.
• W2031036478 date "2012-01-01" @default.
• W2031036478 modified "2023-10-15" @default.
• W2031036478 title "Morelloflavone, a biflavonoid inhibitor of migration-related kinases, ameliorates atherosclerosis in mice" @default.
• W2031036478 cites W1886864374 @default.
• W2031036478 cites W1972756507 @default.
• W2031036478 cites W2008081490 @default.
• W2031036478 cites W2051850195 @default.
• W2031036478 cites W2070517369 @default.
• W2031036478 cites W2071095554 @default.
• W2031036478 cites W2074209817 @default.
• W2031036478 cites W2076522499 @default.
• W2031036478 cites W2091404021 @default.
• W2031036478 cites W2103530895 @default.
• W2031036478 cites W2109807835 @default.
• W2031036478 cites W2112112294 @default.
• W2031036478 cites W2114215066 @default.
• W2031036478 cites W2122386838 @default.
• W2031036478 cites W2126609967 @default.
• W2031036478 cites W2153408202 @default.
• W2031036478 cites W2154162144 @default.
• W2031036478 cites W2157099670 @default.
• W2031036478 cites W2186019492 @default.
• W2031036478 cites W4256475235 @default.
• W2031036478 doi "https://doi.org/10.1152/ajpheart.00669.2011" @default.
• W2031036478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3339857" @default.
• W2031036478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22058152" @default.
• W2031036478 hasPublicationYear "2012" @default.
• W2031036478 type Work @default.
• W2031036478 sameAs 2031036478 @default.
• W2031036478 citedByCount "19" @default.
• W2031036478 countsByYear W20310364782012 @default.
• W2031036478 countsByYear W20310364782014 @default.
• W2031036478 countsByYear W20310364782016 @default.
• W2031036478 countsByYear W20310364782017 @default.
• W2031036478 countsByYear W20310364782018 @default.
• W2031036478 countsByYear W20310364782019 @default.
• W2031036478 countsByYear W20310364782021 @default.
• W2031036478 countsByYear W20310364782022 @default.
• W2031036478 countsByYear W20310364782023 @default.
• W2031036478 crossrefType "journal-article" @default.
• W2031036478 hasAuthorship W2031036478A5014472905 @default.
• W2031036478 hasAuthorship W2031036478A5016774211 @default.
• W2031036478 hasAuthorship W2031036478A5021123195 @default.
• W2031036478 hasAuthorship W2031036478A5043599549 @default.
• W2031036478 hasAuthorship W2031036478A5055523921 @default.
• W2031036478 hasBestOaLocation W20310364782 @default.
• W2031036478 hasConcept C134018914 @default.
• W2031036478 hasConcept C142724271 @default.
• W2031036478 hasConcept C184235292 @default.
• W2031036478 hasConcept C185592680 @default.
• W2031036478 hasConcept C189165786 @default.
• W2031036478 hasConcept C204232928 @default.
• W2031036478 hasConcept C2778163477 @default.
• W2031036478 hasConcept C2779395532 @default.
• W2031036478 hasConcept C2780072125 @default.
• W2031036478 hasConcept C2781156865 @default.
• W2031036478 hasConcept C2992686903 @default.
• W2031036478 hasConcept C43554185 @default.
• W2031036478 hasConcept C55493867 @default.
• W2031036478 hasConcept C71924100 @default.
• W2031036478 hasConcept C98274493 @default.
• W2031036478 hasConceptScore W2031036478C134018914 @default.
• W2031036478 hasConceptScore W2031036478C142724271 @default.
• W2031036478 hasConceptScore W2031036478C184235292 @default.
• W2031036478 hasConceptScore W2031036478C185592680 @default.
• W2031036478 hasConceptScore W2031036478C189165786 @default.
• W2031036478 hasConceptScore W2031036478C204232928 @default.
• W2031036478 hasConceptScore W2031036478C2778163477 @default.
• W2031036478 hasConceptScore W2031036478C2779395532 @default.
• W2031036478 hasConceptScore W2031036478C2780072125 @default.
• W2031036478 hasConceptScore W2031036478C2781156865 @default.
• W2031036478 hasConceptScore W2031036478C2992686903 @default.
• W2031036478 hasConceptScore W2031036478C43554185 @default.
• W2031036478 hasConceptScore W2031036478C55493867 @default.
• W2031036478 hasConceptScore W2031036478C71924100 @default.
• W2031036478 hasConceptScore W2031036478C98274493 @default.
• W2031036478 hasIssue "2" @default.
• W2031036478 hasLocation W20310364781 @default.
• W2031036478 hasLocation W20310364782 @default.
• W2031036478 hasLocation W20310364783 @default.
• W2031036478 hasLocation W20310364784 @default.
• W2031036478 hasOpenAccess W2031036478 @default.
• W2031036478 hasPrimaryLocation W20310364781 @default.
• W2031036478 hasRelatedWork W1983094339 @default.
• W2031036478 hasRelatedWork W2009475965 @default.
• W2031036478 hasRelatedWork W2057470641 @default.
• W2031036478 hasRelatedWork W2080160665 @default.
• W2031036478 hasRelatedWork W2171519536 @default.
• W2031036478 hasRelatedWork W2174098513 @default.
• W2031036478 hasRelatedWork W2345206408 @default.
• W2031036478 hasRelatedWork W2356484687 @default.

• next