FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031050147> ?p ?o ?g. }

• W2031050147 endingPage "333" @default.
• W2031050147 startingPage "324" @default.
• W2031050147 abstract "Temporally graded retrograde amnesia is observed in human patients with medial temporal lobe lesions as well as in animal models of medial temporal lobe lesions. A time-limited role for these structures in memory recall has also been suggested by the observation that the rodent hippocampus and entorhinal cortex are activated during the retrieval of recent but not of remote memories. One notable exception is the recall of remote memories for platform locations in the water maze, which requires an intact hippocampus and results in hippocampal activation irrespective of the age of the memory. These findings raise the question whether the hippocampus is always involved in the recall of spatial memories or, alternatively, whether it might be required for procedural computations in the water maze task, such as for calculating a path to a hidden platform. We performed spatial memory testing in radial maze tasks to distinguish between these possibilities. Radial maze tasks require a choice between spatial locations on a center platform and thus have a lesser requirement for navigation than the water maze. However, we used a behavioral design in the radial maze that retained other aspects of the standard water maze task, such as the use of multiple start locations and retention testing in a single trial. Using the immediate early gene c-fos as a marker for neuronal activation, we found that all hippocampal subregions were more activated during the recall of remote compared to recent spatial memories. In areas CA3 and CA1, activation during remote memory testing was higher than in rats that were merely reexposed to the testing environment after the same time interval. Conversely, Fos levels in the dentate gyrus were increased after retention testing to the extent that was also observed in the corresponding exposure control group. This pattern of hippocampal activation was also obtained in a second version of the task that only used a single start arm instead of multiple start arms. The CA3 and CA1 activation during remote memory recall is consistent with the interpretation that an older memory might require increased pattern completion and/or relearning after longer time intervals. Irrespective of whether the hippocampus is required for remote memory recall, the hippocampus might engage in computations that either support recall of remote memories or that update remote memories." @default.
• W2031050147 created "2016-06-24" @default.
• W2031050147 creator A5002945859 @default.
• W2031050147 creator A5004477135 @default.
• W2031050147 creator A5010397720 @default.
• W2031050147 creator A5029179790 @default.
• W2031050147 creator A5078665068 @default.
• W2031050147 creator A5086029955 @default.
• W2031050147 creator A5087186906 @default.
• W2031050147 date "2013-11-01" @default.
• W2031050147 modified "2023-10-06" @default.
• W2031050147 title "Hippocampal activation during the recall of remote spatial memories in radial maze tasks" @default.
• W2031050147 cites W1595894560 @default.
• W2031050147 cites W1611256317 @default.
• W2031050147 cites W1675950512 @default.
• W2031050147 cites W1957947226 @default.
• W2031050147 cites W1964186645 @default.
• W2031050147 cites W1975898250 @default.
• W2031050147 cites W1979248527 @default.
• W2031050147 cites W1985278030 @default.
• W2031050147 cites W1985582399 @default.
• W2031050147 cites W1994611219 @default.
• W2031050147 cites W1998632588 @default.
• W2031050147 cites W2003102216 @default.
• W2031050147 cites W2005862509 @default.
• W2031050147 cites W2007316566 @default.
• W2031050147 cites W2012355262 @default.
• W2031050147 cites W2017816448 @default.
• W2031050147 cites W2018947767 @default.
• W2031050147 cites W2024758252 @default.
• W2031050147 cites W2027864257 @default.
• W2031050147 cites W2029439671 @default.
• W2031050147 cites W2035138948 @default.
• W2031050147 cites W2038680295 @default.
• W2031050147 cites W2038813826 @default.
• W2031050147 cites W2046460887 @default.
• W2031050147 cites W2047057213 @default.
• W2031050147 cites W2053205229 @default.
• W2031050147 cites W2058601367 @default.
• W2031050147 cites W2062022610 @default.
• W2031050147 cites W2063268059 @default.
• W2031050147 cites W2071438822 @default.
• W2031050147 cites W2081263388 @default.
• W2031050147 cites W2088445784 @default.
• W2031050147 cites W2091569372 @default.
• W2031050147 cites W2095256251 @default.
• W2031050147 cites W2098553579 @default.
• W2031050147 cites W2100351972 @default.
• W2031050147 cites W2109237775 @default.
• W2031050147 cites W2129789527 @default.
• W2031050147 cites W2140892656 @default.
• W2031050147 cites W2151688688 @default.
• W2031050147 cites W2153899356 @default.
• W2031050147 cites W2160071886 @default.
• W2031050147 cites W2166720769 @default.
• W2031050147 cites W4243308533 @default.
• W2031050147 doi "https://doi.org/10.1016/j.nlm.2013.05.007" @default.
• W2031050147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23742919" @default.
• W2031050147 hasPublicationYear "2013" @default.
• W2031050147 type Work @default.
• W2031050147 sameAs 2031050147 @default.
• W2031050147 citedByCount "23" @default.
• W2031050147 countsByYear W20310501472014 @default.
• W2031050147 countsByYear W20310501472015 @default.
• W2031050147 countsByYear W20310501472016 @default.
• W2031050147 countsByYear W20310501472018 @default.
• W2031050147 countsByYear W20310501472019 @default.
• W2031050147 countsByYear W20310501472020 @default.
• W2031050147 countsByYear W20310501472022 @default.
• W2031050147 crossrefType "journal-article" @default.
• W2031050147 hasAuthorship W2031050147A5002945859 @default.
• W2031050147 hasAuthorship W2031050147A5004477135 @default.
• W2031050147 hasAuthorship W2031050147A5010397720 @default.
• W2031050147 hasAuthorship W2031050147A5029179790 @default.
• W2031050147 hasAuthorship W2031050147A5078665068 @default.
• W2031050147 hasAuthorship W2031050147A5086029955 @default.
• W2031050147 hasAuthorship W2031050147A5087186906 @default.
• W2031050147 hasConcept C100660578 @default.
• W2031050147 hasConcept C12515866 @default.
• W2031050147 hasConcept C13260007 @default.
• W2031050147 hasConcept C148762608 @default.
• W2031050147 hasConcept C15744967 @default.
• W2031050147 hasConcept C169760540 @default.
• W2031050147 hasConcept C169900460 @default.
• W2031050147 hasConcept C180747234 @default.
• W2031050147 hasConcept C21963081 @default.
• W2031050147 hasConcept C2778186239 @default.
• W2031050147 hasConcept C2780715579 @default.
• W2031050147 hasConcept C2781099131 @default.
• W2031050147 hasConcept C2781161787 @default.
• W2031050147 hasConcept C43729271 @default.
• W2031050147 hasConcept C44752575 @default.
• W2031050147 hasConceptScore W2031050147C100660578 @default.
• W2031050147 hasConceptScore W2031050147C12515866 @default.
• W2031050147 hasConceptScore W2031050147C13260007 @default.
• W2031050147 hasConceptScore W2031050147C148762608 @default.
• W2031050147 hasConceptScore W2031050147C15744967 @default.
• W2031050147 hasConceptScore W2031050147C169760540 @default.

• next