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• W2031053225 abstract "Treatment of a human cell line (HXG-2), established from a metastatic melanoma, with retinoic acid (RA) induced morphologic differentiation and eliminated its cloning capacity in soft agar. With the v-erb B oncogene as a probe, slot blot hybridization of genomic DNA from parental HXG-2 cells did not show epidermal growth factor (EGF) receptor gene amplification as compared with normal diploid fibroblasts. Analysis of RNA as well as EGF receptor determinations from HXG-2 and RA-treated HXG-2 cells showed essentially no differences, indicating that RA treatment does not modulate EGF receptor gene expression. Although enhanced EGF receptor expression is found in some advanced-stage melanomas, RA-induced changes in the transformation phenotype of cell line HXG-2 probably do not result from modulation of the EGF-mediated pathway." @default.
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• W2031053225 date "1990-06-01" @default.
• W2031053225 modified "2023-09-26" @default.
• W2031053225 title "Epidermal growth factor receptor expression in a retinoic acid-treated human melanoma cell line" @default.
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• W2031053225 doi "https://doi.org/10.1016/0165-4608(90)90111-m" @default.
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