FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031054154> ?p ?o ?g. }

• W2031054154 endingPage "5999" @default.
• W2031054154 startingPage "5993" @default.
• W2031054154 abstract "We have examined the properties of two Drosophila RNA polymerase II mutants, C4 and S1, during elongation, pyrophosphorolysis, and DmS-II-stimulated transcript cleavage. The C4 and S1 mutants contain a single amino acid substitution in the largest and second largest subunits, respectively. Compared with wild type, C4 had a lower elongation rate and was less efficient at reading through intrinsic elongation blocks. S1 had a higher elongation rate than wild type and was more efficient at reading through the same blocks. During elongation, C4 and wild type responded similarly to DmS-II and NH4+, whereas the S1 mutant was less responsive to both. Differences between the two mutants also appeared during DmS-II-mediated transcript cleavage and pyrophosphorolysis. During extended pyrophosphorolysis, S1 polymerase was fastest and C4 polymerase was slowest at generating the final pattern of shortened transcripts. S1 and wild type were equal in the rate of extended DmS-II-mediated transcript cleavage, and C4 was slower. Our results suggest that the S1 mutation increases the time spent by the polymerase in elongation competent mode and that the C4 mutation may affect the movement of the polymerase. We have examined the properties of two Drosophila RNA polymerase II mutants, C4 and S1, during elongation, pyrophosphorolysis, and DmS-II-stimulated transcript cleavage. The C4 and S1 mutants contain a single amino acid substitution in the largest and second largest subunits, respectively. Compared with wild type, C4 had a lower elongation rate and was less efficient at reading through intrinsic elongation blocks. S1 had a higher elongation rate than wild type and was more efficient at reading through the same blocks. During elongation, C4 and wild type responded similarly to DmS-II and NH4+, whereas the S1 mutant was less responsive to both. Differences between the two mutants also appeared during DmS-II-mediated transcript cleavage and pyrophosphorolysis. During extended pyrophosphorolysis, S1 polymerase was fastest and C4 polymerase was slowest at generating the final pattern of shortened transcripts. S1 and wild type were equal in the rate of extended DmS-II-mediated transcript cleavage, and C4 was slower. Our results suggest that the S1 mutation increases the time spent by the polymerase in elongation competent mode and that the C4 mutation may affect the movement of the polymerase." @default.
• W2031054154 created "2016-06-24" @default.
• W2031054154 creator A5037458498 @default.
• W2031054154 creator A5054455401 @default.
• W2031054154 creator A5066986010 @default.
• W2031054154 creator A5074762963 @default.
• W2031054154 date "1996-03-01" @default.
• W2031054154 modified "2023-10-16" @default.
• W2031054154 title "Drosophila RNA Polymerase II Mutants That Affect Transcription Elongation" @default.
• W2031054154 cites W1480264538 @default.
• W2031054154 cites W1501611496 @default.
• W2031054154 cites W1518174569 @default.
• W2031054154 cites W1520503974 @default.
• W2031054154 cites W1533478806 @default.
• W2031054154 cites W1551546158 @default.
• W2031054154 cites W1563789995 @default.
• W2031054154 cites W1567034030 @default.
• W2031054154 cites W1568843108 @default.
• W2031054154 cites W1586160554 @default.
• W2031054154 cites W1595785723 @default.
• W2031054154 cites W1598028840 @default.
• W2031054154 cites W1967615956 @default.
• W2031054154 cites W1978520289 @default.
• W2031054154 cites W1983375834 @default.
• W2031054154 cites W1989048710 @default.
• W2031054154 cites W2035597391 @default.
• W2031054154 cites W2036067282 @default.
• W2031054154 cites W2062114156 @default.
• W2031054154 cites W2069923908 @default.
• W2031054154 cites W2079924615 @default.
• W2031054154 cites W2093608893 @default.
• W2031054154 cites W2133568487 @default.
• W2031054154 cites W94613862 @default.
• W2031054154 doi "https://doi.org/10.1074/jbc.271.11.5993" @default.
• W2031054154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8626382" @default.
• W2031054154 hasPublicationYear "1996" @default.
• W2031054154 type Work @default.
• W2031054154 sameAs 2031054154 @default.
• W2031054154 citedByCount "40" @default.
• W2031054154 countsByYear W20310541542012 @default.
• W2031054154 countsByYear W20310541542013 @default.
• W2031054154 countsByYear W20310541542014 @default.
• W2031054154 countsByYear W20310541542015 @default.
• W2031054154 countsByYear W20310541542016 @default.
• W2031054154 countsByYear W20310541542017 @default.
• W2031054154 countsByYear W20310541542018 @default.
• W2031054154 countsByYear W20310541542019 @default.
• W2031054154 countsByYear W20310541542020 @default.
• W2031054154 countsByYear W20310541542021 @default.
• W2031054154 countsByYear W20310541542023 @default.
• W2031054154 crossrefType "journal-article" @default.
• W2031054154 hasAuthorship W2031054154A5037458498 @default.
• W2031054154 hasAuthorship W2031054154A5054455401 @default.
• W2031054154 hasAuthorship W2031054154A5066986010 @default.
• W2031054154 hasAuthorship W2031054154A5074762963 @default.
• W2031054154 hasBestOaLocation W20310541541 @default.
• W2031054154 hasConcept C101762097 @default.
• W2031054154 hasConcept C104317684 @default.
• W2031054154 hasConcept C112950240 @default.
• W2031054154 hasConcept C138885662 @default.
• W2031054154 hasConcept C143065580 @default.
• W2031054154 hasConcept C150194340 @default.
• W2031054154 hasConcept C151730666 @default.
• W2031054154 hasConcept C153911025 @default.
• W2031054154 hasConcept C175156509 @default.
• W2031054154 hasConcept C179926584 @default.
• W2031054154 hasConcept C191897082 @default.
• W2031054154 hasConcept C192562407 @default.
• W2031054154 hasConcept C207583985 @default.
• W2031054154 hasConcept C2776449523 @default.
• W2031054154 hasConcept C33947775 @default.
• W2031054154 hasConcept C41895202 @default.
• W2031054154 hasConcept C43369102 @default.
• W2031054154 hasConcept C55493867 @default.
• W2031054154 hasConcept C64350747 @default.
• W2031054154 hasConcept C67705224 @default.
• W2031054154 hasConcept C82381507 @default.
• W2031054154 hasConcept C86803240 @default.
• W2031054154 hasConceptScore W2031054154C101762097 @default.
• W2031054154 hasConceptScore W2031054154C104317684 @default.
• W2031054154 hasConceptScore W2031054154C112950240 @default.
• W2031054154 hasConceptScore W2031054154C138885662 @default.
• W2031054154 hasConceptScore W2031054154C143065580 @default.
• W2031054154 hasConceptScore W2031054154C150194340 @default.
• W2031054154 hasConceptScore W2031054154C151730666 @default.
• W2031054154 hasConceptScore W2031054154C153911025 @default.
• W2031054154 hasConceptScore W2031054154C175156509 @default.
• W2031054154 hasConceptScore W2031054154C179926584 @default.
• W2031054154 hasConceptScore W2031054154C191897082 @default.
• W2031054154 hasConceptScore W2031054154C192562407 @default.
• W2031054154 hasConceptScore W2031054154C207583985 @default.
• W2031054154 hasConceptScore W2031054154C2776449523 @default.
• W2031054154 hasConceptScore W2031054154C33947775 @default.
• W2031054154 hasConceptScore W2031054154C41895202 @default.
• W2031054154 hasConceptScore W2031054154C43369102 @default.
• W2031054154 hasConceptScore W2031054154C55493867 @default.
• W2031054154 hasConceptScore W2031054154C64350747 @default.
• W2031054154 hasConceptScore W2031054154C67705224 @default.

• next