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- W2031059266 abstract "The topoisomerase inhibitors represent a distinct class of chemotherapy drugs with a distinct and highly specific mechanism of action. Through an inhibition of the nuclear enzymes topoisomerase I or II they inhibit mechanisms which allow normal DNA replication to occur, leading ultimately to cell death. The role of the topoisomerase inhibitors has been assessed in a number of gynaecological malignancies. Topotecan and oral etoposide have both been shown to have efficacy as single agents in patients with ovarian cancer whose disease has relapsed following platinum and paclitaxel chemotherapy. Randomised controlled trials which incorporate topotecan into first-line therapy for both ovarian and cervical carcinoma are underway. Their role in other gynaecological settings is less clear and continues to be defined in clinical studies." @default.
- W2031059266 created "2016-06-24" @default.
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- W2031059266 date "2002-09-01" @default.
- W2031059266 modified "2023-09-23" @default.
- W2031059266 title "The role of topoisomerase inhibitors in gynaecological oncology" @default.
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- W2031059266 doi "https://doi.org/10.1016/s1471-7697(02)00004-7" @default.
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