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- W2031068458 abstract "Ribosome biogenesis involves an integrated series of binding events coupled with conformational changes that ultimately result in the formation of a functional macromolecular complex. In vitro, Escherichia coli 30 S subunit assembly occurs in a cooperative manner with the ordered addition of 20 ribosomal proteins (r-proteins) with 16 S rRNA. The assembly pathway for 30 S subunits has been dissected in vitro into three steps, where specific r-proteins associate with 16 S rRNA early in 30 S subunit assembly, followed by a mid-assembly conformational rearrangement of the complex that then enables the remaining r-proteins to associate in the final step. Although the three steps of 30 S subunit assembly have been known for some time, few details have been elucidated about changes that occur as a result of these three specific stages. Here, we present a detailed analysis of the concerted early and late stages of small ribosomal subunit assembly. Conformational changes, roles for base-pairing and r-proteins at specific stages of assembly, and a polar nature to the assembly process have been revealed. This work has allowed a more comprehensive and global view of E. coli 30 S ribosomal subunit assembly to be obtained." @default.
- W2031068458 created "2016-06-24" @default.
- W2031068458 creator A5012968432 @default.
- W2031068458 creator A5041143201 @default.
- W2031068458 date "2005-11-01" @default.
- W2031068458 modified "2023-10-14" @default.
- W2031068458 title "Analysis of Conformational Changes in 16 S rRNA During the Course of 30 S Subunit Assembly" @default.
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- W2031068458 doi "https://doi.org/10.1016/j.jmb.2005.09.056" @default.
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