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- W2031090073 abstract "Coumarins are still under investigation for versatile bioactivity because they have unique properties such as presence of lactone carbonyl group, planarity, conjugation, and photosensitivity. All these phenomena are remarkable for synthesis of some miscellaneous agents.Dopamine inhibitors. Dopamine-releasing activity is responsible for several disorders. The coumarin nucleus with a hydroxyl group and 3-diaryl pyrazole derivatives at the C4 position are effective for dopamine inhibition.DNA-PK inhibitors. DNA-dependent protein kinases (DNA-PK) are key factors in DNA-damage response. DNA-PK are overexpressed in several tumor cells. It was revealed that the steric effect at the C6 and C7 positions decreases the inhibitory activity. Thienyl substitution at the C7 position increases the activity as a compound with C6 substitution, whereas methoxy and phenyl groups at C6 and C7 positions, respectively, are also effective for synthesis of DNA-PK inhibitors.Antipsychotic agents. Methyl group or 2-methoxy phenyl piperazine at the C3 position. At the C4 position, the methyl group, n-propyl group, and phenyl group are effective, whereas only the methyl group is effective at the C5 position. At the C6 position, the chlorine group and, at the C8 position, the methyl and chlorine groups show moderate activity. The presence of a 4-carbon chain length of an alkoxy bridge is also effective at the C8 position.Diphenolase inhibitors. Thiosemicarbazide and ester groups present at the C3 position are effective for showing diphenolase inhibition activity." @default.
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- W2031090073 date "1999-09-01" @default.
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- W2031090073 title "Understanding Bovine Fertility" @default.
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- W2031090073 doi "https://doi.org/10.1053/tvjl.1998.0320" @default.
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