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- W2031092118 abstract "We show here that the protein InsA, which is encoded by IS 1 and binds specifically to the terminal inverted repeats of this insertion sequence, negatively regulates IS 1 transposition activity. We demonstrate that it inhibits both IS 1-mediated cointegrate formation and transposition of a synthetic IS 1-based transposon (‘omegon’Ω-on). These results also indicate that the Ω-on which does not itself encode IS 1 transposition functions can be complemented in trans, presumably by the copies of IS 1 resident in the Escherichia coli chromosome. Using insA-lacZ gene fusions, we show that at least part of this effect can be explained by the ability of InsA to repress expression of IS 1-encoded genes both in cis or in trans. The experiments involving Ω-on transposition raise the possibility that InsA inhibits transposition directly by competition with the transposase for their cognate site within the ends of IS 1." @default.
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- W2031092118 date "1990-03-01" @default.
- W2031092118 modified "2023-09-30" @default.
- W2031092118 title "The regulatory role of the IS 1-encoded InsA protein in transposition" @default.
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- W2031092118 doi "https://doi.org/10.1111/j.1365-2958.1990.tb00613.x" @default.
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