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- W2031100337 abstract "566 The level of UPROT correlates with renal graft survival. ACEi reduce UPROT and slow the progression of native renal diseases. However, ACEi are traditionally avoided in Tx recipients because of concern about causing acute renal failure with these drugs. In this study we assessed the effects of low-dose ACEi in renal Tx recipients with UPROT. Seventy renal Tx recipients(57 CAD; 13 LRD) with UPROT>500mg/day received low dose Enalapril (average dose 3±1.7mg/day, range: 1.25 to 10mg/day). Changes in Cr, potassium(K), hemoglobin (Hb) and UPROT were assessed acutely (2-4 wks) and long term(follow up 2.3±1.3 years). Table22% of patients had the ACEi stopped due to: angioedema (N=2), cough (N=3), and due to a rise in Cr and or K (N=11). While on ACEI 29% of patients had a K≥5.5 mEq/L at some time post initiation and 10% (N=7) had a K of greater than or equal to 6.0 mEq/L. The Hb decreased by greater than 1.0 gm in 42% of patients. UPROT declined in 71% of patients while on ACEi. 32% of patients were nephrotic (>3.5 gm UPROT) prior to ACEi and 17% remained nephrotic on ACEi. 56% of patients who remained nephrotic on ACEi lost their graft while 14% of those who had less than nephrotic range UPROT while on ACEi lost their graft (p=0.01 by Chi-squared). UPROT while on ACEi correlated with graft loss by multi variate analysis (p=0.01) Conclusion. Low dose ACEi therapy can significantly reduce proteinuria in the renal Tx patients. A reduction in proteinuria in response to ACEi correlates with an improved graft survival. This therapy can be safely used but careful follow up is necessary as a drop in hemoglobin or hyperkalemia may occur." @default.
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- W2031100337 date "1998-05-01" @default.
- W2031100337 modified "2023-09-25" @default.
- W2031100337 title "LOW-DOSE ANGIOTENSIN CONVERTING ENZYME INHIBITORS (ACEi) ARE SAFE AND EFFECTIVE IN REDUCING PROTEINURIA (UPROT) IN RENAL ALLOGRAFT RECIPIENTS." @default.
- W2031100337 doi "https://doi.org/10.1097/00007890-199805131-00564" @default.
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