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- W2031103691 abstract "We have used cloned adult X. laevis α- and β-globin cDNAs to analyze globin genes in X. laevis DNA. We detected α1- and β1-globin genes which contain intervening sequences and code for the major adult globins, plus additional diverged α2- and β2-globin genes of unknown coding potential. Unlike the case in mammals, the X. laevis α1- and β1-globin genes are closely linked and occur in the sequence 5′-α1-9 kb-β1-3′. The α2- and β2-globin genes are also linked, and analysis of globin genes in X. tropicalis suggests that this duplication of an α-β-globin gene pair in X. laevis is the result of chromosome duplication by tetraploidization. The close linkage of α- and β-globin genes in Xenopus provides evidence that vertebrate α- and β-globin genes evolved by tandem duplication of a single primordial globin gene." @default.
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- W2031103691 date "1980-09-01" @default.
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- W2031103691 title "Linkage of adult α- and β-globin genes in X. laevis and gene duplication by tetraploidization" @default.
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- W2031103691 doi "https://doi.org/10.1016/0092-8674(80)90493-6" @default.
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