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- W2031114823 abstract "Approximately one third of human breast carcinomas are hormoen dependent and regress upon reduction of circulating estrogen levels. Traditional treatment strategies utilized surgical ablative methods to lower estrogen concentrations as treatment of breast cancer. Currently, investigative emphasis is focused upon development of highly specific antiestrogens and inhibitors of estrogen production. The enzyme, aromatase, as the terminal step in estrogen biosynthesis, is a logical target for blockade with potent and specific inhibitors. The earliest available aromatase antagonist, aminoglutethimide, suppresses estrogen production to the same extent as surgical ablation and is an effective treatment for breast cancer. Aminoglutethimide, however, blocks other cytochrome P-450-mediated steroid hydroxylations, requires concomitant glucocorticoid administration, and is associated with initial side effects. Several more specific inhibitors by destroying aromatase irreversibly as well as by competitive inhibition. One of these, 4-hydroxy-androstenedione, has been intensively studied in animals and is undergoing clinical trial. New data regarding these inhibitors further emphasize the key role of aromatase in estrogen production and the practical utility of blocking this enzyme." @default.
- W2031114823 created "2016-06-24" @default.
- W2031114823 creator A5040377065 @default.
- W2031114823 creator A5081817848 @default.
- W2031114823 creator A5091426157 @default.
- W2031114823 date "1986-01-01" @default.
- W2031114823 modified "2023-10-07" @default.
- W2031114823 title "Aromatase in breast cancer and the role of aminoglutethimide and other aromatase inhibitors" @default.
- W2031114823 cites W1483986092 @default.
- W2031114823 cites W1491226100 @default.
- W2031114823 cites W1507820521 @default.
- W2031114823 cites W1521370281 @default.
- W2031114823 cites W1543741367 @default.
- W2031114823 cites W1568189494 @default.
- W2031114823 cites W1576953181 @default.
- W2031114823 cites W1594805342 @default.
- W2031114823 cites W1601438131 @default.
- W2031114823 cites W1634452176 @default.
- W2031114823 cites W1827138247 @default.
- W2031114823 cites W1911425566 @default.
- W2031114823 cites W1967864099 @default.
- W2031114823 cites W1968450987 @default.
- W2031114823 cites W1970737941 @default.
- W2031114823 cites W1971928844 @default.
- W2031114823 cites W1974618825 @default.
- W2031114823 cites W1975705936 @default.
- W2031114823 cites W1976271647 @default.
- W2031114823 cites W1976997610 @default.
- W2031114823 cites W1980697583 @default.
- W2031114823 cites W1982420904 @default.
- W2031114823 cites W1983079035 @default.
- W2031114823 cites W1983150960 @default.
- W2031114823 cites W1985666419 @default.
- W2031114823 cites W1987557870 @default.
- W2031114823 cites W1987688859 @default.
- W2031114823 cites W1988239692 @default.
- W2031114823 cites W1988259060 @default.
- W2031114823 cites W1988472511 @default.
- W2031114823 cites W1989616049 @default.
- W2031114823 cites W1989707220 @default.
- W2031114823 cites W1989895444 @default.
- W2031114823 cites W1990362952 @default.
- W2031114823 cites W1990958094 @default.
- W2031114823 cites W1991322100 @default.
- W2031114823 cites W1991347374 @default.
- W2031114823 cites W1991869978 @default.
- W2031114823 cites W1993364496 @default.
- W2031114823 cites W1993585146 @default.
- W2031114823 cites W1993730294 @default.
- W2031114823 cites W1994587492 @default.
- W2031114823 cites W1994622756 @default.
- W2031114823 cites W1999332617 @default.
- W2031114823 cites W2006398865 @default.
- W2031114823 cites W2006909140 @default.
- W2031114823 cites W2007368250 @default.
- W2031114823 cites W2009696126 @default.
- W2031114823 cites W2010118270 @default.
- W2031114823 cites W2010993034 @default.
- W2031114823 cites W2011528027 @default.
- W2031114823 cites W2013048030 @default.
- W2031114823 cites W2013438876 @default.
- W2031114823 cites W2013776505 @default.
- W2031114823 cites W2015547131 @default.
- W2031114823 cites W2017030328 @default.
- W2031114823 cites W2018482033 @default.
- W2031114823 cites W2019528389 @default.
- W2031114823 cites W2020339611 @default.
- W2031114823 cites W2020941163 @default.
- W2031114823 cites W2025992428 @default.
- W2031114823 cites W2026180048 @default.
- W2031114823 cites W2027698083 @default.
- W2031114823 cites W2028976040 @default.
- W2031114823 cites W2029458486 @default.
- W2031114823 cites W2037352383 @default.
- W2031114823 cites W2038126714 @default.
- W2031114823 cites W2039312666 @default.
- W2031114823 cites W2040440140 @default.
- W2031114823 cites W2040589999 @default.
- W2031114823 cites W2043457457 @default.
- W2031114823 cites W2046612073 @default.
- W2031114823 cites W2047510202 @default.
- W2031114823 cites W2048174515 @default.
- W2031114823 cites W2049190772 @default.
- W2031114823 cites W2050060522 @default.
- W2031114823 cites W2052403769 @default.
- W2031114823 cites W2053665902 @default.
- W2031114823 cites W2057196832 @default.
- W2031114823 cites W2059487486 @default.
- W2031114823 cites W2061834130 @default.
- W2031114823 cites W2062799050 @default.
- W2031114823 cites W2064003005 @default.
- W2031114823 cites W2064925491 @default.
- W2031114823 cites W2065066624 @default.
- W2031114823 cites W2066998567 @default.
- W2031114823 cites W2067686187 @default.
- W2031114823 cites W2068399718 @default.
- W2031114823 cites W2070215800 @default.
- W2031114823 cites W2074510874 @default.