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• W2031125728 abstract "Background Dopaminergic (DAergic) neurons of the ventral tegmental area ( VTA ) are important for the rewarding and reinforcing properties of alcohol and other drugs of abuse. Regulation of the firing of DAergic VTA neurons is controlled by a number of factors, including autoregulation of firing by D 2 dopamine (DA) receptors. The inhibitory effects of DA on these neurons exhibit concentration‐ and time‐dependent desensitization, which we have termed dopamine inhibition reversal ( DIR ), as it requires concurrent stimulation of D 1/ D 5 and D2 receptors. Methods Extracellular recording of DAergic VTA neurons in brain slices was used to test the effects of ethanol ( E t OH ) (10 to 80 mM) on DIR . Results DIR was reduced by concentrations of E t OH as low as 10 mM and was blocked by higher E t OH concentrations. In addition, as we have shown that reversal of inhibition by the selective D2 agonist quinpirole can be observed in the presence of an activator of protein kinase C ( PKC ), we tested whether E t OH could antagonize the reversal of quinpirole inhibition in the presence of phorbol 12‐myristate 13‐acetate ( PMA ). E t OH (80 mM) blocked the reversal of quinpirole seen in the presence of PMA, suggesting that the antagonism of DIR by E t OH is owing to an action at a stage in the mechanism at or distal to PKC . Once achieved, DIR is not antagonized by E t OH . Conclusions The blockade by relatively low concentrations of E t OH of DIR may play an important role in the spectrum of action of E t OH on DAergic neurons of the VTA and may be important in the acute and chronic actions of E t OH on the excitability of these brain reward/reinforcement neurons." @default.
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• W2031125728 date "2012-05-02" @default.
• W2031125728 modified "2023-10-18" @default.
• W2031125728 title "Ethanol Blocks the Reversal of Prolonged Dopamine Inhibition of Dopaminergic Neurons of the Ventral Tegmental Area" @default.
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• W2031125728 doi "https://doi.org/10.1111/j.1530-0277.2012.01814.x" @default.
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