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• W2031129247 abstract "We tested the ability of seven MCF-7 strains to undergo DNA fragmentation, as measured by DNA laddering, following doxorubicin-induced apoptosis. Four strains were found to undergo DNA laddering while three were not. All strains were inhibited by doxorubicin, although sensitivity differed. Finally, we show by detection of sub-G1 DNA that doxorubicin induced the same fold increase in apoptosis in MCF-7-ATCC, which did not ladder, and MCF-7-MG, which did ladder. Therefore, detection of DNA ladders is not an accurate indicator of apoptosis in MCF-7 cells as fragmentation of DNA appears to vary between strains." @default.
• W2031129247 created "2016-06-24" @default.
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• W2031129247 date "1999-09-01" @default.
• W2031129247 modified "2023-09-25" @default.
• W2031129247 title "Strain-specific differences in formation of apoptotic DNA ladders in MCF-7 breast cancer cells" @default.
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• W2031129247 doi "https://doi.org/10.1016/s0304-3835(99)00208-6" @default.
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