FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031136802> ?p ?o ?g. }

• W2031136802 endingPage "e13649" @default.
• W2031136802 startingPage "e13649" @default.
• W2031136802 abstract "Background Intermittent preventive treatment (IPT) of malaria involves administration of curative doses of antimalarials at specified time points to vulnerable populations in endemic areas, regardless whether a subject is known to be infected. The effect of this new intervention on the development and maintenance of protective immunity needs further understanding. We have investigated how seasonal IPT affects the genetic diversity of Plasmodium falciparum infections and the risk of subsequent clinical malaria. Material and Methods The study included 2227 Ghanaian children (3–59 months) who were given sulphadoxine-pyrimethamine (SP) bimonthly, artesunate plus amodiaquine (AS+AQ) monthly or bimonthly, or placebo monthly for six months spanning the malaria transmission season. Blood samples collected at three post-interventional surveys were analysed by genotyping of the polymorphic merozoite surface protein 2 gene. Malaria morbidity and anaemia was monitored during 12 months follow-up. Results Monthly IPT with AS+AQ resulted in a marked reduction in number of concurrent clones and only children parasite negative just after the intervention period developed clinical malaria during follow-up. In the placebo group, children without parasites as well as those infected with ≥2 clones had a reduced risk of subsequent malaria. The bimonthly SP or AS+AQ groups had similar number of clones as placebo after intervention; however, diversity and parasite negativity did not predict the risk of malaria. An interaction effect showed that multiclonal infections were only associated with protection in children without intermittent treatment. Conclusion Molecular typing revealed effects of the intervention not detected by ordinary microscopy. Effective seasonal IPT temporarily reduced the prevalence and genetic diversity of P. falciparum infections. The reduced risk of malaria in children with multiclonal infections only seen in untreated children suggests that persistence of antigenically diverse P. falciparum infections is important for the maintenance of protective malaria immunity in high transmission settings." @default.
• W2031136802 created "2016-06-24" @default.
• W2031136802 creator A5000300261 @default.
• W2031136802 creator A5017274140 @default.
• W2031136802 creator A5026726987 @default.
• W2031136802 creator A5027270405 @default.
• W2031136802 creator A5039978049 @default.
• W2031136802 creator A5049720596 @default.
• W2031136802 creator A5056228812 @default.
• W2031136802 date "2010-10-27" @default.
• W2031136802 modified "2023-10-02" @default.
• W2031136802 title "Influences of Intermittent Preventive Treatment and Persistent Multiclonal Plasmodium falciparum Infections on Clinical Malaria Risk" @default.
• W2031136802 cites W1495305629 @default.
• W2031136802 cites W1974204803 @default.
• W2031136802 cites W1984891431 @default.
• W2031136802 cites W1991638152 @default.
• W2031136802 cites W1995833178 @default.
• W2031136802 cites W2022925846 @default.
• W2031136802 cites W2027697581 @default.
• W2031136802 cites W2029237652 @default.
• W2031136802 cites W2036179744 @default.
• W2031136802 cites W2054582078 @default.
• W2031136802 cites W2058543649 @default.
• W2031136802 cites W2060283099 @default.
• W2031136802 cites W2061658473 @default.
• W2031136802 cites W2074223924 @default.
• W2031136802 cites W2091659825 @default.
• W2031136802 cites W2104697202 @default.
• W2031136802 cites W2105813928 @default.
• W2031136802 cites W2109179635 @default.
• W2031136802 cites W2123747315 @default.
• W2031136802 cites W2131545842 @default.
• W2031136802 cites W2138888301 @default.
• W2031136802 cites W2142275831 @default.
• W2031136802 cites W2147895892 @default.
• W2031136802 cites W2149476220 @default.
• W2031136802 cites W2154608105 @default.
• W2031136802 cites W2159394280 @default.
• W2031136802 cites W2161045462 @default.
• W2031136802 cites W2169649862 @default.
• W2031136802 cites W2788073857 @default.
• W2031136802 doi "https://doi.org/10.1371/journal.pone.0013649" @default.
• W2031136802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2965101" @default.
• W2031136802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21048970" @default.
• W2031136802 hasPublicationYear "2010" @default.
• W2031136802 type Work @default.
• W2031136802 sameAs 2031136802 @default.
• W2031136802 citedByCount "16" @default.
• W2031136802 countsByYear W20311368022012 @default.
• W2031136802 countsByYear W20311368022013 @default.
• W2031136802 countsByYear W20311368022014 @default.
• W2031136802 countsByYear W20311368022015 @default.
• W2031136802 countsByYear W20311368022017 @default.
• W2031136802 countsByYear W20311368022018 @default.
• W2031136802 countsByYear W20311368022019 @default.
• W2031136802 countsByYear W20311368022020 @default.
• W2031136802 countsByYear W20311368022021 @default.
• W2031136802 crossrefType "journal-article" @default.
• W2031136802 hasAuthorship W2031136802A5000300261 @default.
• W2031136802 hasAuthorship W2031136802A5017274140 @default.
• W2031136802 hasAuthorship W2031136802A5026726987 @default.
• W2031136802 hasAuthorship W2031136802A5027270405 @default.
• W2031136802 hasAuthorship W2031136802A5039978049 @default.
• W2031136802 hasAuthorship W2031136802A5049720596 @default.
• W2031136802 hasAuthorship W2031136802A5056228812 @default.
• W2031136802 hasBestOaLocation W20311368021 @default.
• W2031136802 hasConcept C104317684 @default.
• W2031136802 hasConcept C126322002 @default.
• W2031136802 hasConcept C135763542 @default.
• W2031136802 hasConcept C142724271 @default.
• W2031136802 hasConcept C203014093 @default.
• W2031136802 hasConcept C204787440 @default.
• W2031136802 hasConcept C27081682 @default.
• W2031136802 hasConcept C2776992834 @default.
• W2031136802 hasConcept C2777035104 @default.
• W2031136802 hasConcept C2777617192 @default.
• W2031136802 hasConcept C2778048844 @default.
• W2031136802 hasConcept C2778059366 @default.
• W2031136802 hasConcept C2778301690 @default.
• W2031136802 hasConcept C2778371730 @default.
• W2031136802 hasConcept C31467283 @default.
• W2031136802 hasConcept C54355233 @default.
• W2031136802 hasConcept C71924100 @default.
• W2031136802 hasConcept C86803240 @default.
• W2031136802 hasConceptScore W2031136802C104317684 @default.
• W2031136802 hasConceptScore W2031136802C126322002 @default.
• W2031136802 hasConceptScore W2031136802C135763542 @default.
• W2031136802 hasConceptScore W2031136802C142724271 @default.
• W2031136802 hasConceptScore W2031136802C203014093 @default.
• W2031136802 hasConceptScore W2031136802C204787440 @default.
• W2031136802 hasConceptScore W2031136802C27081682 @default.
• W2031136802 hasConceptScore W2031136802C2776992834 @default.
• W2031136802 hasConceptScore W2031136802C2777035104 @default.
• W2031136802 hasConceptScore W2031136802C2777617192 @default.
• W2031136802 hasConceptScore W2031136802C2778048844 @default.
• W2031136802 hasConceptScore W2031136802C2778059366 @default.
• W2031136802 hasConceptScore W2031136802C2778301690 @default.
• W2031136802 hasConceptScore W2031136802C2778371730 @default.

• next