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• W2031140198 abstract "In this paper, we report new protease inhibitory activity of plakortide E towards cathepsins and cathepsin-like parasitic proteases. We further report on its anti-parasitic activity against Trypanosoma brucei with an IC50 value of 5 μM and without cytotoxic effects against J774.1 macrophages at 100 μM concentration. Plakortide E was isolated from the sponge Plakortis halichondroides using enzyme assay-guided fractionation and identified by NMR spectroscopy and mass spectrometry. Furthermore, enzyme kinetic studies confirmed plakortide E as a non-competitive, slowly-binding, reversible inhibitor of rhodesain." @default.
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• W2031140198 date "2014-05-02" @default.
• W2031140198 modified "2023-10-01" @default.
• W2031140198 title "Identification of Plakortide E from the Caribbean Sponge Plakortis halichondroides as a Trypanocidal Protease Inhibitor using Bioactivity-Guided Fractionation" @default.
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• W2031140198 doi "https://doi.org/10.3390/md12052614" @default.
• W2031140198 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4052307" @default.
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