Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031142492> ?p ?o ?g. }
- W2031142492 endingPage "192" @default.
- W2031142492 startingPage "186" @default.
- W2031142492 abstract "This study was undertaken to analyze the effect of an engineered, killer decapeptide (KP) on Leishmania major and Leishmania infantum promastigotes. The KP was synthesized on the basis of the sequence of a recombinant, single-chain anti-idiotypic antibody acting as a functional internal image of a yeast killer toxin. The evaluation of in vitro inhibitory activity of KP on L. major and L. infantum, release of intracellular green fluorescent protein (GFP) molecules by L. major, DNA fragmentation, and ultrastructural analysis (TEM) of L. infantum upon KP treatment were performed. KP presented antiproliferative and leishmanicidal activity with LC(50)/1 day of 58 and 72 microM for L. major and L. infantum, respectively. A dose-dependent decrease in proliferation and increase of killing of promastigotes was seen after KP treatment. No DNA fragmentation in L. infantum promastigotes or release of intracellular GFP molecules on peptide treatment of a GFP expressing L. major clone was demonstrated. Moreover the plasma-membrane was not disrupted, but, by TEM analysis, intracellular damage was observed." @default.
- W2031142492 created "2016-06-24" @default.
- W2031142492 creator A5007413456 @default.
- W2031142492 creator A5009136557 @default.
- W2031142492 creator A5024907543 @default.
- W2031142492 creator A5039812301 @default.
- W2031142492 creator A5045561296 @default.
- W2031142492 creator A5086261022 @default.
- W2031142492 date "2006-07-01" @default.
- W2031142492 modified "2023-10-01" @default.
- W2031142492 title "Activity of an engineered synthetic killer peptide on Leishmania major and Leishmania infantum promastigotes" @default.
- W2031142492 cites W1565479825 @default.
- W2031142492 cites W1574072708 @default.
- W2031142492 cites W1855219841 @default.
- W2031142492 cites W1880246550 @default.
- W2031142492 cites W1968157068 @default.
- W2031142492 cites W1980443126 @default.
- W2031142492 cites W1996319090 @default.
- W2031142492 cites W2004051711 @default.
- W2031142492 cites W2005547658 @default.
- W2031142492 cites W2011722714 @default.
- W2031142492 cites W2020216656 @default.
- W2031142492 cites W2029927999 @default.
- W2031142492 cites W2030299761 @default.
- W2031142492 cites W2037063107 @default.
- W2031142492 cites W2037082550 @default.
- W2031142492 cites W2039070421 @default.
- W2031142492 cites W2054602599 @default.
- W2031142492 cites W2057222889 @default.
- W2031142492 cites W2068541511 @default.
- W2031142492 cites W2084889403 @default.
- W2031142492 cites W2096415553 @default.
- W2031142492 cites W2110894948 @default.
- W2031142492 cites W2114983395 @default.
- W2031142492 cites W2124608160 @default.
- W2031142492 cites W2138213214 @default.
- W2031142492 cites W2138427542 @default.
- W2031142492 cites W2145617201 @default.
- W2031142492 cites W2155983259 @default.
- W2031142492 cites W2156414842 @default.
- W2031142492 cites W2157122286 @default.
- W2031142492 cites W2164354626 @default.
- W2031142492 cites W2171997929 @default.
- W2031142492 cites W2342967665 @default.
- W2031142492 cites W2462160920 @default.
- W2031142492 cites W4238998907 @default.
- W2031142492 cites W4242978687 @default.
- W2031142492 cites W4319291097 @default.
- W2031142492 doi "https://doi.org/10.1016/j.exppara.2006.01.002" @default.
- W2031142492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16487518" @default.
- W2031142492 hasPublicationYear "2006" @default.
- W2031142492 type Work @default.
- W2031142492 sameAs 2031142492 @default.
- W2031142492 citedByCount "26" @default.
- W2031142492 countsByYear W20311424922012 @default.
- W2031142492 countsByYear W20311424922014 @default.
- W2031142492 countsByYear W20311424922015 @default.
- W2031142492 countsByYear W20311424922016 @default.
- W2031142492 countsByYear W20311424922018 @default.
- W2031142492 countsByYear W20311424922019 @default.
- W2031142492 countsByYear W20311424922020 @default.
- W2031142492 countsByYear W20311424922022 @default.
- W2031142492 countsByYear W20311424922023 @default.
- W2031142492 crossrefType "journal-article" @default.
- W2031142492 hasAuthorship W2031142492A5007413456 @default.
- W2031142492 hasAuthorship W2031142492A5009136557 @default.
- W2031142492 hasAuthorship W2031142492A5024907543 @default.
- W2031142492 hasAuthorship W2031142492A5039812301 @default.
- W2031142492 hasAuthorship W2031142492A5045561296 @default.
- W2031142492 hasAuthorship W2031142492A5086261022 @default.
- W2031142492 hasConcept C104317684 @default.
- W2031142492 hasConcept C136764020 @default.
- W2031142492 hasConcept C153911025 @default.
- W2031142492 hasConcept C18903297 @default.
- W2031142492 hasConcept C190283241 @default.
- W2031142492 hasConcept C191015642 @default.
- W2031142492 hasConcept C203014093 @default.
- W2031142492 hasConcept C2776555147 @default.
- W2031142492 hasConcept C2778689377 @default.
- W2031142492 hasConcept C2781092759 @default.
- W2031142492 hasConcept C2781257258 @default.
- W2031142492 hasConcept C31573885 @default.
- W2031142492 hasConcept C40767141 @default.
- W2031142492 hasConcept C41008148 @default.
- W2031142492 hasConcept C43759708 @default.
- W2031142492 hasConcept C55493867 @default.
- W2031142492 hasConcept C71928629 @default.
- W2031142492 hasConcept C79879829 @default.
- W2031142492 hasConcept C86803240 @default.
- W2031142492 hasConceptScore W2031142492C104317684 @default.
- W2031142492 hasConceptScore W2031142492C136764020 @default.
- W2031142492 hasConceptScore W2031142492C153911025 @default.
- W2031142492 hasConceptScore W2031142492C18903297 @default.
- W2031142492 hasConceptScore W2031142492C190283241 @default.
- W2031142492 hasConceptScore W2031142492C191015642 @default.
- W2031142492 hasConceptScore W2031142492C203014093 @default.
- W2031142492 hasConceptScore W2031142492C2776555147 @default.
- W2031142492 hasConceptScore W2031142492C2778689377 @default.