FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031142646> ?p ?o ?g. }

• W2031142646 endingPage "78" @default.
• W2031142646 startingPage "65" @default.
• W2031142646 abstract "Ischemia/reperfusion injury (IRI) associated with liver transplantation plays an important role in the induction of graft injury. Prolonged cold storage remains a risk factor for liver graft outcome, especially when steatosis is present. Steatotic livers exhibit exacerbated endoplasmic reticulum (ER) stress that occurs in response to cold IRI. In addition, a defective liver autophagy correlates well with liver damage. Here, we evaluated the combined effect of melatonin and trimetazidine as additives to IGL-1 solution in the modulation of ER stress and autophagy in steatotic liver grafts through activation of AMPK. Steatotic livers were preserved for 24 hr (4°C) in UW or IGL-1 solutions with or without MEL + TMZ and subjected to 2-hr reperfusion (37°C). We assessed hepatic injury (ALT and AST) and function (bile production). We evaluated ER stress (GRP78, PERK, and CHOP) and autophagy (beclin-1, ATG7, LC3B, and P62). Steatotic livers preserved in IGL-1 + MEL + TMZ showed lower injury and better function as compared to those preserved in IGL-1 alone. IGL-1 + MEL + TMZ induced a significant decrease in GRP78, pPERK, and CHOP activation after reperfusion. This was consistent with a major activation of autophagic parameters (beclin-1, ATG7, and LC3B) and AMPK phosphorylation. The inhibition of AMPK induced an increase in ER stress and a significant reduction in autophagy. These data confirm the close relationship between AMPK activation and ER stress and autophagy after cold IRI. The addition of melatonin and TMZ to IGL-1 solution improved steatotic liver graft preservation through AMPK activation, which reduces ER stress and increases autophagy." @default.
• W2031142646 created "2016-06-24" @default.
• W2031142646 creator A5001911137 @default.
• W2031142646 creator A5003010633 @default.
• W2031142646 creator A5015680333 @default.
• W2031142646 creator A5029587764 @default.
• W2031142646 creator A5042051260 @default.
• W2031142646 creator A5048961670 @default.
• W2031142646 creator A5053388640 @default.
• W2031142646 creator A5062464445 @default.
• W2031142646 creator A5063159500 @default.
• W2031142646 creator A5078264944 @default.
• W2031142646 date "2013-03-29" @default.
• W2031142646 modified "2023-10-18" @default.
• W2031142646 title "AMPK involvement in endoplasmic reticulum stress and autophagy modulation after fatty liver graft preservation: a role for melatonin and trimetazidine cocktail" @default.
• W2031142646 cites W1485256456 @default.
• W2031142646 cites W1500479217 @default.
• W2031142646 cites W1909596895 @default.
• W2031142646 cites W1953162515 @default.
• W2031142646 cites W1955689590 @default.
• W2031142646 cites W1970228194 @default.
• W2031142646 cites W1971322794 @default.
• W2031142646 cites W1972557061 @default.
• W2031142646 cites W1973472942 @default.
• W2031142646 cites W1975591624 @default.
• W2031142646 cites W1975996964 @default.
• W2031142646 cites W1978270167 @default.
• W2031142646 cites W1980356545 @default.
• W2031142646 cites W1983803702 @default.
• W2031142646 cites W1986790688 @default.
• W2031142646 cites W1990067998 @default.
• W2031142646 cites W1990233281 @default.
• W2031142646 cites W1994505198 @default.
• W2031142646 cites W1996780964 @default.
• W2031142646 cites W1998178297 @default.
• W2031142646 cites W2007505836 @default.
• W2031142646 cites W2007743440 @default.
• W2031142646 cites W2012168390 @default.
• W2031142646 cites W2015205016 @default.
• W2031142646 cites W2016710706 @default.
• W2031142646 cites W2017463539 @default.
• W2031142646 cites W2020189193 @default.
• W2031142646 cites W2025517512 @default.
• W2031142646 cites W2045012179 @default.
• W2031142646 cites W2046074477 @default.
• W2031142646 cites W2049266148 @default.
• W2031142646 cites W2054811797 @default.
• W2031142646 cites W2057256337 @default.
• W2031142646 cites W2058428986 @default.
• W2031142646 cites W2060636173 @default.
• W2031142646 cites W2063747022 @default.
• W2031142646 cites W2065215092 @default.
• W2031142646 cites W2067176564 @default.
• W2031142646 cites W2072759932 @default.
• W2031142646 cites W2074174723 @default.
• W2031142646 cites W2083770932 @default.
• W2031142646 cites W2084256872 @default.
• W2031142646 cites W2085371272 @default.
• W2031142646 cites W2091553788 @default.
• W2031142646 cites W2091619548 @default.
• W2031142646 cites W2108431211 @default.
• W2031142646 cites W2109342861 @default.
• W2031142646 cites W2111757370 @default.
• W2031142646 cites W2113620806 @default.
• W2031142646 cites W2117748926 @default.
• W2031142646 cites W2119224030 @default.
• W2031142646 cites W2126545702 @default.
• W2031142646 cites W2134235502 @default.
• W2031142646 cites W2134493521 @default.
• W2031142646 cites W2144612928 @default.
• W2031142646 cites W2151569537 @default.
• W2031142646 cites W2161980140 @default.
• W2031142646 cites W2164908051 @default.
• W2031142646 cites W2166598466 @default.
• W2031142646 cites W2322187697 @default.
• W2031142646 cites W25138627 @default.
• W2031142646 doi "https://doi.org/10.1111/jpi.12051" @default.
• W2031142646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23551302" @default.
• W2031142646 hasPublicationYear "2013" @default.
• W2031142646 type Work @default.
• W2031142646 sameAs 2031142646 @default.
• W2031142646 citedByCount "83" @default.
• W2031142646 countsByYear W20311426462013 @default.
• W2031142646 countsByYear W20311426462014 @default.
• W2031142646 countsByYear W20311426462015 @default.
• W2031142646 countsByYear W20311426462016 @default.
• W2031142646 countsByYear W20311426462017 @default.
• W2031142646 countsByYear W20311426462018 @default.
• W2031142646 countsByYear W20311426462019 @default.
• W2031142646 countsByYear W20311426462020 @default.
• W2031142646 countsByYear W20311426462021 @default.
• W2031142646 countsByYear W20311426462022 @default.
• W2031142646 countsByYear W20311426462023 @default.
• W2031142646 crossrefType "journal-article" @default.
• W2031142646 hasAuthorship W2031142646A5001911137 @default.
• W2031142646 hasAuthorship W2031142646A5003010633 @default.
• W2031142646 hasAuthorship W2031142646A5015680333 @default.
• W2031142646 hasAuthorship W2031142646A5029587764 @default.

• next