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• W2031143033 abstract "BMP Signaling and Transcription Bone morphogenetic protein signaling (BMP) is widely used for dorsoventral axis determination in animal embryos, which involves specific interactions between BMPs and their antagonists. In the genomes of many animals, the gene Pinhead is encoded as a neighbor of one of the BMP ligand genes, Admp (antidorsalizing morphogenetic protein). Working in ascidian tailbud-stage embryos, Imai et al. (p. 964 ) now show that Pinhead is an antagonist of ADMP and is important for the establishment of the sharp boundary of the ventral epidermis. Transcription of Pinhead disturbs transcription of Admp by a cis -acting mechanism, which may explain the mutually exclusive expression of these two functionally opposed genes." @default.
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• W2031143033 date "2012-08-24" @default.
• W2031143033 modified "2023-10-17" @default.
• W2031143033 title "Cis <i>-</i> Acting Transcriptional Repression Establishes a Sharp Boundary in Chordate Embryos" @default.
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• W2031143033 doi "https://doi.org/10.1126/science.1222488" @default.
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