Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031143400> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2031143400 endingPage "304" @default.
- W2031143400 startingPage "293" @default.
- W2031143400 abstract "Administration of steroid hormones evokes a rapid fall in the amount of cytoplasmic receptors in target tissues. This has been considered to be a consequence of the receptor translocation to nuclei, but the physiological significane of depletion of the cytoplasmic receptors after hormone administration has not been fully elucidated. In the present study, depletion and replenishment of the cytoplasmic glucocorticoid receptor in rat tissues were examined after the administration of glucocorticoids of different biological potencies. Dose dependent depletion was observed in all tissues examined and doses required for complete depletion of the receptor were correlated with biological potencies of steroid administered. The receptor in the heart and the skeletal muscle was relatively sensitive to hormone injection while more than 4 times the amount of steroids was required to induce a similar effect in the thymus and the spleen. The duration of the period of depletion of the receptor in cytosols was also dose dependent and correlated to the biological potency of steroid administered. Replenishment took place earlier in the thymus and the spleen than in the heart and the skeletal muscle. Significantly lower binding affinity was observed in the replenished receptors. The administration of cycloheximide in a dose which inhibits more than 95% of3H-leucine incorporation did not influence either the depletion or the replenishment of the receptor induced by hormone injection. In conclusion, depletion and replenishment of the cytoplasmic glucocorticoid receptor appeared to be closely correlated to the physiological action of hormones." @default.
- W2031143400 created "2016-06-24" @default.
- W2031143400 creator A5064309565 @default.
- W2031143400 date "1981-01-01" @default.
- W2031143400 modified "2023-09-27" @default.
- W2031143400 title "Depletion and replenishment of glucocorticoid receptor in cytosols of rat tissues after administration of various glucocorticoids." @default.
- W2031143400 cites W1578765768 @default.
- W2031143400 cites W167038568 @default.
- W2031143400 cites W1775749144 @default.
- W2031143400 cites W1976039649 @default.
- W2031143400 cites W1983649348 @default.
- W2031143400 cites W1988522657 @default.
- W2031143400 cites W2000562323 @default.
- W2031143400 cites W2017211490 @default.
- W2031143400 cites W2019684061 @default.
- W2031143400 cites W2034265925 @default.
- W2031143400 cites W2038060715 @default.
- W2031143400 cites W2041050444 @default.
- W2031143400 cites W2048048599 @default.
- W2031143400 cites W2061103522 @default.
- W2031143400 cites W2066749111 @default.
- W2031143400 cites W2073746545 @default.
- W2031143400 cites W2073882664 @default.
- W2031143400 cites W2082921655 @default.
- W2031143400 cites W2208091080 @default.
- W2031143400 cites W2269852949 @default.
- W2031143400 cites W2335807189 @default.
- W2031143400 cites W2418081963 @default.
- W2031143400 cites W1485371842 @default.
- W2031143400 doi "https://doi.org/10.1507/endocrj1954.28.293" @default.
- W2031143400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7308163" @default.
- W2031143400 hasPublicationYear "1981" @default.
- W2031143400 type Work @default.
- W2031143400 sameAs 2031143400 @default.
- W2031143400 citedByCount "26" @default.
- W2031143400 crossrefType "journal-article" @default.
- W2031143400 hasAuthorship W2031143400A5064309565 @default.
- W2031143400 hasBestOaLocation W20311434001 @default.
- W2031143400 hasConcept C121608353 @default.
- W2031143400 hasConcept C126322002 @default.
- W2031143400 hasConcept C134018914 @default.
- W2031143400 hasConcept C170493617 @default.
- W2031143400 hasConcept C185592680 @default.
- W2031143400 hasConcept C190062978 @default.
- W2031143400 hasConcept C23589133 @default.
- W2031143400 hasConcept C2776888042 @default.
- W2031143400 hasConcept C2778128677 @default.
- W2031143400 hasConcept C2780841215 @default.
- W2031143400 hasConcept C2780902042 @default.
- W2031143400 hasConcept C3675279 @default.
- W2031143400 hasConcept C530470458 @default.
- W2031143400 hasConcept C55493867 @default.
- W2031143400 hasConcept C59493245 @default.
- W2031143400 hasConcept C71315377 @default.
- W2031143400 hasConcept C71924100 @default.
- W2031143400 hasConcept C86803240 @default.
- W2031143400 hasConceptScore W2031143400C121608353 @default.
- W2031143400 hasConceptScore W2031143400C126322002 @default.
- W2031143400 hasConceptScore W2031143400C134018914 @default.
- W2031143400 hasConceptScore W2031143400C170493617 @default.
- W2031143400 hasConceptScore W2031143400C185592680 @default.
- W2031143400 hasConceptScore W2031143400C190062978 @default.
- W2031143400 hasConceptScore W2031143400C23589133 @default.
- W2031143400 hasConceptScore W2031143400C2776888042 @default.
- W2031143400 hasConceptScore W2031143400C2778128677 @default.
- W2031143400 hasConceptScore W2031143400C2780841215 @default.
- W2031143400 hasConceptScore W2031143400C2780902042 @default.
- W2031143400 hasConceptScore W2031143400C3675279 @default.
- W2031143400 hasConceptScore W2031143400C530470458 @default.
- W2031143400 hasConceptScore W2031143400C55493867 @default.
- W2031143400 hasConceptScore W2031143400C59493245 @default.
- W2031143400 hasConceptScore W2031143400C71315377 @default.
- W2031143400 hasConceptScore W2031143400C71924100 @default.
- W2031143400 hasConceptScore W2031143400C86803240 @default.
- W2031143400 hasIssue "3" @default.
- W2031143400 hasLocation W20311434001 @default.
- W2031143400 hasLocation W20311434002 @default.
- W2031143400 hasOpenAccess W2031143400 @default.
- W2031143400 hasPrimaryLocation W20311434001 @default.
- W2031143400 hasRelatedWork W1981044771 @default.
- W2031143400 hasRelatedWork W1988863726 @default.
- W2031143400 hasRelatedWork W2016322361 @default.
- W2031143400 hasRelatedWork W2023035210 @default.
- W2031143400 hasRelatedWork W2031062169 @default.
- W2031143400 hasRelatedWork W2034583712 @default.
- W2031143400 hasRelatedWork W2090691291 @default.
- W2031143400 hasRelatedWork W2148328115 @default.
- W2031143400 hasRelatedWork W2414846389 @default.
- W2031143400 hasRelatedWork W2022381224 @default.
- W2031143400 hasVolume "28" @default.
- W2031143400 isParatext "false" @default.
- W2031143400 isRetracted "false" @default.
- W2031143400 magId "2031143400" @default.
- W2031143400 workType "article" @default.