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- W2031146474 abstract "Executive dysfunction arising from involvement of prefrontal cortex is one of the hallmarks of early Alzheimer's disease (AD). Resting-state functional connectivity (RSFC) of brain refers to interregional synchrony of low frequency fluctuations of functional magnetic resonance imaging (fMRI) blood oxygen-level dependent signal acquired during resting state. Multiple large scale spatially distributed networks can be defined by such synchronous activity of brain during rest. Executive network (EN) is one such resting-state network that comprises of brain regions critical for executive functioning (medial prefrontal cortex and paracingulate regions). These brain regions have been shown to be activated during performing task-based fMRI paradigms involving executive functions. Disruption of RSFC involving EN is reported among early stages of AD. Verbal fluency task (VFT) is commonly used for assessing executive function. Rest-fMRI is advantageous, as the interpretation is not confounded by differences in task performance and active participation. This study explores the role of RSFC of EN on VFT performance in a group of patients with mild AD and age-/gender-matched cognitively healthy controls (CHc). 61 right handed persons (mild AD=32; diagnosed according to NIAAA criteria, & CDR = 1 & CHc=29) were recruited after informed written consent. All subjects underwent detailed neurocognitive assessment including VFT (category: fruits, animals & vegetables) followed by neuro-imaging (structural and resting state fMRI). Resting state fMRI was decomposed into independent components using independent component analysis. Group EN was visually identified from obtained components. We performed regression analysis to examine the link between VFT (scores) performance and RSFC of EN, correcting for age and gender variations. We found a significant positive relation between VFT scores and RSFC of regions under EN among the whole group (CHc and mild AD patients) after correcting for age and gender effects. There was a significant difference (but uncorrected at p <0.01) between groups in RSFC of EN. Mild AD patients performed significantly poorer in VFT task. Red voxels represent the group Resting state executive network, green voxels show clusters that significantly (p < 0.05, FWE-corrected) positively related with the score of verbal fluency task (total) for the whole group. With the background of MNI MPRAGE template. Results are corrected for age and gender variation." @default.
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- W2031146474 date "2014-07-01" @default.
- W2031146474 modified "2023-09-27" @default.
- W2031146474 title "P4-139: RESTING STATE FUNCTIONAL CONNECTIVITY OF EXECUTIVE NETWORK PREDICTS THE PERFORMANCE OF COGNITIVE FUNCTION" @default.
- W2031146474 doi "https://doi.org/10.1016/j.jalz.2014.05.1655" @default.
- W2031146474 hasPublicationYear "2014" @default.
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