Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031146859> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2031146859 endingPage "1665" @default.
- W2031146859 startingPage "1665" @default.
- W2031146859 abstract "The NMDA receptor is an ionotropic receptor complex widely distributed in the central nervous system and its activation, particularly in hypoxic conditions such as stroke, traumatic head injury and hypoglycemia, results in a massive influx of calcium ions into the post-synaptic neurones, leading to cell death through the activation of several neurotoxic cascades. The NMDA receptor is a unique ionotropic receptor complex because its activation requires the simultaneous binding of glutamate and glycine and selective antagonists at the glycine binding site are endowed with a better side-effect profile than competitive NMDA antagonists. Then, considerable efforts have been devoted to find potent and selective ligands, resulting in the identification of several classes of glycine antagonists. The research at Glaxo Wellcome has been aimed at the identification of novel in vivo active glycine antagonists, and led to the synthesis and pharmacological characterization of a number of novel, potent and systemically active compounds belonging to different chemical classes." @default.
- W2031146859 created "2016-06-24" @default.
- W2031146859 creator A5006715899 @default.
- W2031146859 creator A5048406456 @default.
- W2031146859 creator A5050905987 @default.
- W2031146859 creator A5084788721 @default.
- W2031146859 date "1990-07-01" @default.
- W2031146859 modified "2023-09-25" @default.
- W2031146859 title "Requirement of glycine for glutamate activity at the NMDA receptor site" @default.
- W2031146859 doi "https://doi.org/10.1016/0014-2999(90)91958-e" @default.
- W2031146859 hasPublicationYear "1990" @default.
- W2031146859 type Work @default.
- W2031146859 sameAs 2031146859 @default.
- W2031146859 citedByCount "7" @default.
- W2031146859 crossrefType "journal-article" @default.
- W2031146859 hasAuthorship W2031146859A5006715899 @default.
- W2031146859 hasAuthorship W2031146859A5048406456 @default.
- W2031146859 hasAuthorship W2031146859A5050905987 @default.
- W2031146859 hasAuthorship W2031146859A5084788721 @default.
- W2031146859 hasConcept C115955781 @default.
- W2031146859 hasConcept C160268369 @default.
- W2031146859 hasConcept C169760540 @default.
- W2031146859 hasConcept C170493617 @default.
- W2031146859 hasConcept C185592680 @default.
- W2031146859 hasConcept C2777756961 @default.
- W2031146859 hasConcept C2778938600 @default.
- W2031146859 hasConcept C2781001490 @default.
- W2031146859 hasConcept C35599011 @default.
- W2031146859 hasConcept C515207424 @default.
- W2031146859 hasConcept C55493867 @default.
- W2031146859 hasConcept C61174792 @default.
- W2031146859 hasConcept C67018056 @default.
- W2031146859 hasConcept C86803240 @default.
- W2031146859 hasConcept C98274493 @default.
- W2031146859 hasConceptScore W2031146859C115955781 @default.
- W2031146859 hasConceptScore W2031146859C160268369 @default.
- W2031146859 hasConceptScore W2031146859C169760540 @default.
- W2031146859 hasConceptScore W2031146859C170493617 @default.
- W2031146859 hasConceptScore W2031146859C185592680 @default.
- W2031146859 hasConceptScore W2031146859C2777756961 @default.
- W2031146859 hasConceptScore W2031146859C2778938600 @default.
- W2031146859 hasConceptScore W2031146859C2781001490 @default.
- W2031146859 hasConceptScore W2031146859C35599011 @default.
- W2031146859 hasConceptScore W2031146859C515207424 @default.
- W2031146859 hasConceptScore W2031146859C55493867 @default.
- W2031146859 hasConceptScore W2031146859C61174792 @default.
- W2031146859 hasConceptScore W2031146859C67018056 @default.
- W2031146859 hasConceptScore W2031146859C86803240 @default.
- W2031146859 hasConceptScore W2031146859C98274493 @default.
- W2031146859 hasIssue "5" @default.
- W2031146859 hasLocation W20311468591 @default.
- W2031146859 hasOpenAccess W2031146859 @default.
- W2031146859 hasPrimaryLocation W20311468591 @default.
- W2031146859 hasRelatedWork W1980899641 @default.
- W2031146859 hasRelatedWork W1991125142 @default.
- W2031146859 hasRelatedWork W2010446018 @default.
- W2031146859 hasRelatedWork W2025676835 @default.
- W2031146859 hasRelatedWork W2084868376 @default.
- W2031146859 hasRelatedWork W2088121448 @default.
- W2031146859 hasRelatedWork W2282244318 @default.
- W2031146859 hasRelatedWork W2802075251 @default.
- W2031146859 hasRelatedWork W4247612648 @default.
- W2031146859 hasRelatedWork W4292210015 @default.
- W2031146859 hasVolume "183" @default.
- W2031146859 isParatext "false" @default.
- W2031146859 isRetracted "false" @default.
- W2031146859 magId "2031146859" @default.
- W2031146859 workType "article" @default.