Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031160192> ?p ?o ?g. }
- W2031160192 endingPage "393" @default.
- W2031160192 startingPage "381" @default.
- W2031160192 abstract "Dorsal horn neurons express many different neuropeptides that modulate sensory perception like the sensation of pain. Inhibitory neurons of the dorsal horn derive from postmitotic neurons that express Pax2, Lbx1 and Lhx1/5, and diversify during maturation. In particular, fractions of maturing inhibitory neurons express various neuropeptides. We demonstrate here that a coordinate molecular mechanism determines inhibitory and peptidergic fate in the developing dorsal horn. A bHLH factor complex that contains Ptf1a acts as upstream regulator and initiates the expression of several downstream transcription factors in the future inhibitory neurons, of which Pax2 is known to determine the neurotransmitter phenotype. We demonstrate here that dynorphin, galanin, NPY, nociceptin and enkephalin expression depends on Ptf1a, indicating that these neuropeptides are expressed in inhibitory neurons. Furthermore, we show that Neurod1/2/6 and Lhx1/5, which act downstream of Ptf1a, control distinct aspects of peptidergic differentiation. In particular, the Neurod1/2/6 factors are essential for dynorphin and galanin expression, whereas the Lhx1/5 factors are essential for NPY expression. We conclude that a transcriptional network operates in maturing dorsal horn neurons that coordinately determines transmitter and peptidergic fate." @default.
- W2031160192 created "2016-06-24" @default.
- W2031160192 creator A5022752761 @default.
- W2031160192 creator A5038465445 @default.
- W2031160192 creator A5069125069 @default.
- W2031160192 creator A5073755996 @default.
- W2031160192 creator A5078966502 @default.
- W2031160192 creator A5080922686 @default.
- W2031160192 creator A5084794599 @default.
- W2031160192 creator A5091513950 @default.
- W2031160192 date "2008-10-01" @default.
- W2031160192 modified "2023-10-17" @default.
- W2031160192 title "A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord" @default.
- W2031160192 cites W1538619419 @default.
- W2031160192 cites W156202311 @default.
- W2031160192 cites W1883044208 @default.
- W2031160192 cites W1923448222 @default.
- W2031160192 cites W1969778262 @default.
- W2031160192 cites W1971401852 @default.
- W2031160192 cites W1973436974 @default.
- W2031160192 cites W1975012076 @default.
- W2031160192 cites W1977360479 @default.
- W2031160192 cites W1979400536 @default.
- W2031160192 cites W1980438916 @default.
- W2031160192 cites W1982630660 @default.
- W2031160192 cites W1986647797 @default.
- W2031160192 cites W1993055783 @default.
- W2031160192 cites W1994047748 @default.
- W2031160192 cites W1994150692 @default.
- W2031160192 cites W1997301708 @default.
- W2031160192 cites W1998341727 @default.
- W2031160192 cites W1998901000 @default.
- W2031160192 cites W2000207589 @default.
- W2031160192 cites W2004257326 @default.
- W2031160192 cites W2004544578 @default.
- W2031160192 cites W2010825018 @default.
- W2031160192 cites W2017974613 @default.
- W2031160192 cites W2019812867 @default.
- W2031160192 cites W2020526396 @default.
- W2031160192 cites W2021655870 @default.
- W2031160192 cites W2025603247 @default.
- W2031160192 cites W2030148675 @default.
- W2031160192 cites W2035022202 @default.
- W2031160192 cites W2038998122 @default.
- W2031160192 cites W2043659972 @default.
- W2031160192 cites W2049141458 @default.
- W2031160192 cites W2050976800 @default.
- W2031160192 cites W2051875568 @default.
- W2031160192 cites W2057027433 @default.
- W2031160192 cites W2059086372 @default.
- W2031160192 cites W2060563696 @default.
- W2031160192 cites W2061509079 @default.
- W2031160192 cites W2062548336 @default.
- W2031160192 cites W2076269981 @default.
- W2031160192 cites W2076993465 @default.
- W2031160192 cites W2080720024 @default.
- W2031160192 cites W2082785396 @default.
- W2031160192 cites W2083242763 @default.
- W2031160192 cites W2084240125 @default.
- W2031160192 cites W2084264246 @default.
- W2031160192 cites W2088520225 @default.
- W2031160192 cites W2090639766 @default.
- W2031160192 cites W2095309569 @default.
- W2031160192 cites W2101033679 @default.
- W2031160192 cites W2103302443 @default.
- W2031160192 cites W2123043547 @default.
- W2031160192 cites W2135769528 @default.
- W2031160192 cites W2139909837 @default.
- W2031160192 cites W2142486892 @default.
- W2031160192 cites W2143416290 @default.
- W2031160192 cites W2149519740 @default.
- W2031160192 cites W2155214369 @default.
- W2031160192 cites W2156509935 @default.
- W2031160192 cites W2160697532 @default.
- W2031160192 cites W2167493288 @default.
- W2031160192 cites W2169542007 @default.
- W2031160192 doi "https://doi.org/10.1016/j.ydbio.2008.08.002" @default.
- W2031160192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18721803" @default.
- W2031160192 hasPublicationYear "2008" @default.
- W2031160192 type Work @default.
- W2031160192 sameAs 2031160192 @default.
- W2031160192 citedByCount "78" @default.
- W2031160192 countsByYear W20311601922012 @default.
- W2031160192 countsByYear W20311601922013 @default.
- W2031160192 countsByYear W20311601922014 @default.
- W2031160192 countsByYear W20311601922015 @default.
- W2031160192 countsByYear W20311601922016 @default.
- W2031160192 countsByYear W20311601922017 @default.
- W2031160192 countsByYear W20311601922018 @default.
- W2031160192 countsByYear W20311601922019 @default.
- W2031160192 countsByYear W20311601922020 @default.
- W2031160192 countsByYear W20311601922021 @default.
- W2031160192 countsByYear W20311601922022 @default.
- W2031160192 crossrefType "journal-article" @default.
- W2031160192 hasAuthorship W2031160192A5022752761 @default.
- W2031160192 hasAuthorship W2031160192A5038465445 @default.
- W2031160192 hasAuthorship W2031160192A5069125069 @default.
- W2031160192 hasAuthorship W2031160192A5073755996 @default.