Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031162004> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2031162004 endingPage "240A" @default.
- W2031162004 startingPage "240A" @default.
- W2031162004 abstract "Although acetylsalicylic acid (ASA) is the most widely used drug in Kawasaki disease because of its anti-inflammatory and antiplatelet effect, a previous study failed to show efficacy of ASA 30 mg/kg/day in reducing coronary involvement in this disease. We have recently documented erratic and often reduced absorption of ASA in Kawasaki disease such that 30 mg/kg/day could not be assumed to yield therapeutic concentrations. In the present study the efficacy of high dose salicylates in reducing the coronary features of Kawasaki disease was assessed in 36 children who received ASA 80-180 mg/kg/day, and 18 who did not receive high dose salicylates during the febrile phase of the disease and whose fever was controlled mainly with acetaminophen. The two groups were comparable with respect to age and body weight. In the ASA-treated group the dose was adjusted to achieve a concentration ≥ 20 mg/dl. There were significantly more cases of coronary disease in the non-treated group (50%) than in the salicylate-treated group (16.6%) (P=0.014). Due to impaired absorption of ASA during the febrile phase of the disease salicylate serum concentrations achieved per given dose were on average 50% those observed during the non-febrile phase. Despite the difficulty in achieving therapeutic concentrations of salicylate during the febrile phase of Kawasaki disease even with doses as high as 100 mg/kg/day, this dose appears to reduce coronary artery involvement." @default.
- W2031162004 created "2016-06-24" @default.
- W2031162004 creator A5026206882 @default.
- W2031162004 creator A5029201310 @default.
- W2031162004 creator A5032032320 @default.
- W2031162004 creator A5061077391 @default.
- W2031162004 date "1985-04-01" @default.
- W2031162004 modified "2023-09-26" @default.
- W2031162004 title "775 PROBABLE EFFICACY OF HIGH DOSE SALICYLATE IN REDUCING CORONARY INVOLVEMENT IN KAWASAKI DISEASE" @default.
- W2031162004 doi "https://doi.org/10.1203/00006450-198504000-00805" @default.
- W2031162004 hasPublicationYear "1985" @default.
- W2031162004 type Work @default.
- W2031162004 sameAs 2031162004 @default.
- W2031162004 citedByCount "1" @default.
- W2031162004 crossrefType "journal-article" @default.
- W2031162004 hasAuthorship W2031162004A5026206882 @default.
- W2031162004 hasAuthorship W2031162004A5029201310 @default.
- W2031162004 hasAuthorship W2031162004A5032032320 @default.
- W2031162004 hasAuthorship W2031162004A5061077391 @default.
- W2031162004 hasBestOaLocation W20311620041 @default.
- W2031162004 hasConcept C126322002 @default.
- W2031162004 hasConcept C2776820930 @default.
- W2031162004 hasConcept C2777628954 @default.
- W2031162004 hasConcept C2778213512 @default.
- W2031162004 hasConcept C2778722691 @default.
- W2031162004 hasConcept C2779134260 @default.
- W2031162004 hasConcept C2780035454 @default.
- W2031162004 hasConcept C2781423770 @default.
- W2031162004 hasConcept C71924100 @default.
- W2031162004 hasConcept C90924648 @default.
- W2031162004 hasConcept C98274493 @default.
- W2031162004 hasConceptScore W2031162004C126322002 @default.
- W2031162004 hasConceptScore W2031162004C2776820930 @default.
- W2031162004 hasConceptScore W2031162004C2777628954 @default.
- W2031162004 hasConceptScore W2031162004C2778213512 @default.
- W2031162004 hasConceptScore W2031162004C2778722691 @default.
- W2031162004 hasConceptScore W2031162004C2779134260 @default.
- W2031162004 hasConceptScore W2031162004C2780035454 @default.
- W2031162004 hasConceptScore W2031162004C2781423770 @default.
- W2031162004 hasConceptScore W2031162004C71924100 @default.
- W2031162004 hasConceptScore W2031162004C90924648 @default.
- W2031162004 hasConceptScore W2031162004C98274493 @default.
- W2031162004 hasIssue "4" @default.
- W2031162004 hasLocation W20311620041 @default.
- W2031162004 hasOpenAccess W2031162004 @default.
- W2031162004 hasPrimaryLocation W20311620041 @default.
- W2031162004 hasRelatedWork W1970831995 @default.
- W2031162004 hasRelatedWork W2030720859 @default.
- W2031162004 hasRelatedWork W2039141366 @default.
- W2031162004 hasRelatedWork W2159249503 @default.
- W2031162004 hasRelatedWork W2353387411 @default.
- W2031162004 hasRelatedWork W2510410303 @default.
- W2031162004 hasRelatedWork W2622322548 @default.
- W2031162004 hasRelatedWork W4243712096 @default.
- W2031162004 hasRelatedWork W4376255503 @default.
- W2031162004 hasRelatedWork W82350142 @default.
- W2031162004 hasVolume "19" @default.
- W2031162004 isParatext "false" @default.
- W2031162004 isRetracted "false" @default.
- W2031162004 magId "2031162004" @default.
- W2031162004 workType "article" @default.