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- W2031170422 abstract "Immature dendritic cells (DCs) sample tissue-specific antigens (TSAs) and process them for “crosspresentation” via major histocompatibility complex (MHC) class I and II molecules. Findings with adoptively transferred T cell receptor (TCR)-transgenic CD8+ T cells in transgenic mice expressing model TSA indicate that this process contributes to tolerance induction of CD8+ T cells, a phenomenon termed “crosstolerance.” However, up to now it has been unknown whether “crosstolerance” can also control autoimmune T cells specific for physiological nontransgenic TSA. Here, we showed that a DC-specific deficiency in uptake of apoptotic material inhibits crosspresentation in vivo. This defect allowed the accumulation of fully functional autoreactive CD8+ T cells that could be activated for autoimmune attack in peripheral lymphoid organs. Thus, our data demonstrate the importance of crosstolerance induction by DCs as a vital instrument for controlling self-reactive T cells from the peripheral repertoire and preventing autoimmune disease." @default.
- W2031170422 created "2016-06-24" @default.
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- W2031170422 date "2008-04-01" @default.
- W2031170422 modified "2023-09-25" @default.
- W2031170422 title "Constitutive Crosspresentation of Tissue Antigens by Dendritic Cells Controls CD8+ T Cell Tolerance In Vivo" @default.
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- W2031170422 doi "https://doi.org/10.1016/j.immuni.2008.02.018" @default.
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